PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11472209-4	2001	Molecular modeling studies, corroborated by a recent crystal structure determination of the ternary complex of P. carinii DHFR--NADPH bound to TAB, predicted that modifications to the acetoxy residue of the lead inhibitor could exploit binding opportunities in the vicinity of an active site pocket bounded by residues Ile33, Lys37, and Leu72.	NADP	128-133	dihydrofolate reductase	Rattus norvegicus	122-126	
27229326-8	2016	However, rDHFR-1 showed no reducing activity towards dihydrofolate, and exhibited about ~6-fold lower affinity towards NADPH than wtDHFR.	NADP	119-124	dihydrofolate reductase	Rattus norvegicus	9-16	
12037296-0	2002	Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.	NADP	168-173	dihydrofolate reductase	Rattus norvegicus	113-136	
9701044-0	1997	A synthetic peptide corresponding to the putative dihydrofolate reductase domain of nitric oxide synthase inhibits uncoupled NADPH oxidation.	NADP	125-130	dihydrofolate reductase	Rattus norvegicus	50-73	
1613754-10	1992	Kinetic studies with rat liver DHFR show that MBP is an inhibitor that competes with NADPH as well as dihydrofolate.	NADP	85-90	dihydrofolate reductase	Rattus norvegicus	31-35