PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28092678-5 2017 PFKFB4 was also required to support the synthesis and regeneration of nicotinamide adenine dinucleotide phosphate (NADPH) in p53-deficient cancer cells. NADP 70-113 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Homo sapiens 0-6 28092678-5 2017 PFKFB4 was also required to support the synthesis and regeneration of nicotinamide adenine dinucleotide phosphate (NADPH) in p53-deficient cancer cells. NADP 115-120 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Homo sapiens 0-6 22576206-1 2012 Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells. NADP 261-266 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Homo sapiens 118-171 22576206-1 2012 Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells. NADP 261-266 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Homo sapiens 173-179