PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28932959-4 2017 Hexose-6 phosphate dehydrogenase (H6PDH) is a key regulator of 11beta-HSD1 activity via its generation of NADPH. NADP 106-111 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 63-74 29843121-5 2018 Mutations in the corresponding HSD11B1 gene, or in the H6PD gene encoding hexose-6-phosphate dehydrogenase (which supplies the NADPH required for the oxoreductase activity of 11-HSD1), cause apparent cortisone reductase deficiency, a rare syndrome of adrenocortical hyperactivity and hyperandrogenism. NADP 127-132 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 31-38 27431412-5 2016 The 11beta-HSD1 isoform is predominantly a reductase, which catalyzes nicotinamide adenine dinucleotide phosphate hydrogen-dependent conversion of cortisone/11-DHC to cortisol/corticosterone, and is widely expressed and present at the highest levels in the liver, lungs, adipose tissues, ovaries, and central nervous system. NADP 70-113 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 4-15 19121282-1 2009 Tissue specific amplification of glucocorticoid action through NADPH-dependent reduction of inactive glucocorticoid precursors by 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) contributes to the development of visceral obesity, insulin resistance and Type 2 Diabetes. NADP 63-68 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 167-178 24759003-3 2014 Hexose-6-phosphate dehydrogenase (H6PDH) is involved in the production of NADPH, which is a coenzyme for 11beta-HSD1. NADP 74-79 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 105-116 21515335-3 2011 11beta-HSD1 is widely expressed, uses NADP+/NADPH as cofactors, and contributes to the metabolic syndrome and related conditions by increasing cortisol level. NADP 38-43 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-11 21515335-3 2011 11beta-HSD1 is widely expressed, uses NADP+/NADPH as cofactors, and contributes to the metabolic syndrome and related conditions by increasing cortisol level. NADP 44-49 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-11 21869537-2 2011 Hexose-6-phosphate dehydrogenase (H6PD) supplies a crucial cofactor, reduced nicotinamide adenine dinucleotide phosphate (NADPH), which allows HSD11B1 to maintain reductase activity. NADP 77-120 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 143-150 21869537-2 2011 Hexose-6-phosphate dehydrogenase (H6PD) supplies a crucial cofactor, reduced nicotinamide adenine dinucleotide phosphate (NADPH), which allows HSD11B1 to maintain reductase activity. NADP 122-127 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 143-150 19380458-9 2009 Hexose-6-phosphate dehydrogenase, which provides the cofactor NADPH for full activation of 11beta-HSD1, was unaffected by E(2). NADP 62-67 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 91-102 25739654-3 2015 11beta-HSD1 oxo-reductase activity requires the cofactor NADPH, generated by hexose-6-phosphate dehydrogenase. NADP 57-62 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-11 25447798-3 2015 Hexose-6-phosphate dehydrogenase (H6PD), which is colocalized with 11beta-HSD1 in the intralumen of the endoplasmic reticulum, supplies a crucial coenzyme, NADPH, for full reductase activity of 11beta-HSD1. NADP 156-161 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 67-78 25447798-3 2015 Hexose-6-phosphate dehydrogenase (H6PD), which is colocalized with 11beta-HSD1 in the intralumen of the endoplasmic reticulum, supplies a crucial coenzyme, NADPH, for full reductase activity of 11beta-HSD1. NADP 156-161 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 194-205 23125313-2 2012 The reductase activity of 11beta-HSD1 depends on the availability of the cofactor reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) derived from the enzymatic activity of hexose-6-phosphodehydrogenase (H6PD). NADP 98-141 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 26-37 23125313-2 2012 The reductase activity of 11beta-HSD1 depends on the availability of the cofactor reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) derived from the enzymatic activity of hexose-6-phosphodehydrogenase (H6PD). NADP 143-148 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 26-37 22154985-3 2012 In many tissues such as the liver and lung, 11beta-HSD1 behaves primarily as a reductase because of the intracellular enzyme coupling with hexose-6-phosphate dehydrogenase, which uses the NADP+ as cofactor to supply NADPH driving 11beta-HSD1 to function as a reductase. NADP 188-193 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 44-55 22154985-3 2012 In many tissues such as the liver and lung, 11beta-HSD1 behaves primarily as a reductase because of the intracellular enzyme coupling with hexose-6-phosphate dehydrogenase, which uses the NADP+ as cofactor to supply NADPH driving 11beta-HSD1 to function as a reductase. NADP 188-193 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 230-241 20826560-2 2010 Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) depends on hexose-6-phosphate dehydrogenase (H6PD), which physically interacts with 11beta-HSD1 at the luminal surface of the endoplasmic reticulum (ER) membrane and generates reduced nicotinamide adenine dinucleotide phosphate for the reduction of glucocorticoids. NADP 270-313 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 73-84 17593962-2 2007 Experiments determining initial rates of enzyme activity revealed that 11beta-HSD1 can catalyze both the reductase and the dehydrogenase reaction in cell lysates, whereas it predominantly catalyzes the reduction of cortisone to cortisol in intact cells that also express hexose-6-phosphate dehydrogenase (H6PDH), which provides cofactor NADPH. NADP 337-342 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 71-82 18628520-2 2008 11beta-HSD1 oxoreductase activity requires the reduced nicotinamide adenine dinucleotide phosphate-generating enzyme hexose-6-phosphate dehydrogenase (H6PDH) within the endoplasmic reticulum. NADP 55-98 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-11 16855188-4 2006 RESEARCH METHODS AND PROCEDURES: 11beta-HSD-1 and hexose-6-phosphate dehydrogenase (the enzyme responsible for the synthesis of nicotinamide adenine dinucleotide phosphate, the cofactor required for 11beta-HSD-1 oxoreductase activity) mRNA levels were measured using real-time quantitative reverse transcriptase-polymerase chain reaction in abdominal SAT and VAT biopsies obtained from 10 normal-weight and 12 obese women. NADP 128-171 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 33-45 12943516-2 2003 11beta-HSD1 acts predominantly as an oxo-reductase in vivo using NADP(H) as a cofactor to generate cortisol. NADP 65-72 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-11 16431016-1 2006 The NADPH-dependent enzyme type 1 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) activates in a tissue-specific manner circulating pro-glucocorticoid hormones (cortisone in humans) to the 11beta-OH ligand (cortisol in humans), which is able to bind to its cognate receptor and regulate gene transcription. NADP 4-9 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 71-82 15774558-4 2005 11beta-HSD1 is a bidirectional enzyme, but in intact cells displays predominately oxo-reductase activity, a reaction requiring NADPH and leading to activation of glucocorticoids. NADP 127-132 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-11 15466942-4 2004 The molecular basis of cortisone reductase deficiency, the putative "11beta-HSD1 knockout state" in humans, has been defined and is caused by intronic mutations in HSD11B1 that decrease gene transcription together with mutations in hexose-6-phosphate dehydrogenase, an endoluminal enzyme that provides reduced nicotinamide-adenine dinucleotide phosphate as cofactor to 11beta-HSD1 to permit reductase activity. NADP 310-353 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 69-80 15466942-4 2004 The molecular basis of cortisone reductase deficiency, the putative "11beta-HSD1 knockout state" in humans, has been defined and is caused by intronic mutations in HSD11B1 that decrease gene transcription together with mutations in hexose-6-phosphate dehydrogenase, an endoluminal enzyme that provides reduced nicotinamide-adenine dinucleotide phosphate as cofactor to 11beta-HSD1 to permit reductase activity. NADP 310-353 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 164-171 15466942-5 2004 We speculate that hexose-6-phosphate dehydrogenase activity and therefore reduced nicotinamide-adenine dinucleotide phosphate supply may be crucial in determining the directionality of 11beta-HSD1 activity. NADP 82-125 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 185-196 15774558-6 2005 Because H6PDH and 11beta-HSD1 are coexpressed in the inner microsomal compartment of cells, we hypothesized that H6PDH may provide 11beta-HSD1 with NADPH, thus promoting oxo-reductase activity in vivo. NADP 148-153 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 18-29 11469811-2 2001 11beta-HSD1 is believed to act in vivo predominantly as an oxo-reductase using NADP(H) as a cofactor to generate cortisol. NADP 79-86 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-11 8938587-3 1996 Two kinetically distinct isoforms of this enzyme have been characterized in both rodents and man; a low-affinity NADP(H)-dependent enzyme (11 beta-HSD1) which predominantly acts as an oxoreductase and, more recently, a high-affinity NAD-dependent uni-directional dehydrogenase (11 beta-HSD2). NADP 113-120 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 139-151 10962348-8 2000 In bone homogenates, activity was NADP-dependent with a K(m) for F of 4.8 +/- 1.2 micromol/L, suggesting the presence of 11beta-HSD1. NADP 34-38 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 121-132 9000459-5 1997 11beta-HSD-1 is a widespread, NADP(H)-dependent enzyme, which shows bidirectional activity in tissue homogenates and microsomal preparations, but may predominantly function as an 11beta-reductase (regenerating active glucocorticoids) in intact cells. NADP 30-37 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-12 8852827-3 1996 11 beta-HSD-1 is NADP(+)-dependent and has a Km in the micromolar range and bidirectional activity. NADP 17-24 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 0-13 7859916-2 1994 A ubiquitous low affinity NADP+ dependent enzyme (11 beta HSD1) and a tissue specific, high affinity NAD+ dependent form (11 beta HSD2) of 11 beta HSD exist. NADP 26-30 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 50-62 8319828-5 1993 The 11 beta-HSD1A enzyme converted corticosterone and cortisol to their respective 11-dehydro metabolites with an absolute dependence on NADP as co-factor, while the 26 kDa 11 beta-HSD1B protein was unable to metabolize either steroid. NADP 137-141 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 4-11