PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20716294-2 2010 Our studies in endothelium-rubbed bovine pulmonary arteries suggest increased glucose-6-phosphate dehydrogenase levels (compared to coronary arteries) seem to maintain a tonic peroxide-mediated relaxation removed by hypoxia through NADPH fueling superoxide generation from Nox oxidase. NADP 232-237 glucose-6-phosphate dehydrogenase Bos taurus 78-111 15968626-8 2005 When G6PD inhibitors (dehydroepiandrosterone: DHEA and 6-aminonicotinamide: 6-AN), which effectively inhibit the reduction of the NADPH-sensitive dye, brilliant cresyl blue (BCB) in bovine morulae, were added to the culture medium containing 4 mM glucose, embryo development was moderately reduced, but sex ratio skewing was corrected (with 6-AN) or lowered (with DHEA). NADP 130-135 glucose-6-phosphate dehydrogenase Bos taurus 5-9 20160535-3 2010 Our studies have found a key role for glucose-6-phosphate dehydrogenase in bovine pulmonary arterial smooth muscle functioning to maintain elevated levels of cytosolic NADPH which fuels the generation of vasodilator levels of hydrogen peroxide. NADP 168-173 glucose-6-phosphate dehydrogenase Bos taurus 38-71 19996565-6 2010 t-BHQ also increased intracellular glucose-6-phosphate dehydrogenase activity, producing NADPH. NADP 89-94 glucose-6-phosphate dehydrogenase Bos taurus 35-68 19996565-7 2010 Taken together, our findings indicate that t-BHQ treatment activates NADPH generating enzymes such as glucose-6-phosphate dehydrogenase followed by release of NADPH in the cell culture medium, resulting in direct XTT reduction by NADPH. NADP 69-74 glucose-6-phosphate dehydrogenase Bos taurus 102-135 15345489-7 2005 The activity and protein levels of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting PPP enzyme generating cytosolic NADPH, were 1.5-fold higher in BPA than BCA. NADP 127-132 glucose-6-phosphate dehydrogenase Bos taurus 35-68 15826683-7 2005 Activity of G6PDH was determined via measurement of NADP reduction induced by G6P as substrate oxidized by G6PDH in the cytosol of control, BCB- and BCB+ groups; G6PDH activity was significant higher in BCB- COCs than in control and BCB+ COCs. NADP 52-56 glucose-6-phosphate dehydrogenase Bos taurus 12-17 15826683-7 2005 Activity of G6PDH was determined via measurement of NADP reduction induced by G6P as substrate oxidized by G6PDH in the cytosol of control, BCB- and BCB+ groups; G6PDH activity was significant higher in BCB- COCs than in control and BCB+ COCs. NADP 52-56 glucose-6-phosphate dehydrogenase Bos taurus 107-112 15826683-7 2005 Activity of G6PDH was determined via measurement of NADP reduction induced by G6P as substrate oxidized by G6PDH in the cytosol of control, BCB- and BCB+ groups; G6PDH activity was significant higher in BCB- COCs than in control and BCB+ COCs. NADP 52-56 glucose-6-phosphate dehydrogenase Bos taurus 107-112 15760711-1 2005 Glucose-6-phosphate dehydrogenase is the key regulatory enzyme of the pentose phosphate pathway and one of the products of this enzyme; NADPH has a critical role in the defence system against the free radicals. NADP 136-141 glucose-6-phosphate dehydrogenase Bos taurus 0-33 15345489-7 2005 The activity and protein levels of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting PPP enzyme generating cytosolic NADPH, were 1.5-fold higher in BPA than BCA. NADP 127-132 glucose-6-phosphate dehydrogenase Bos taurus 70-74 12615686-1 2003 OBJECTIVE: Glucose-6-phosphate dehydrogenase (G6PD), the principal source of NADPH, serves as an antioxidant enzyme to modulate the redox milieu and nitric oxide synthase activity. NADP 77-82 glucose-6-phosphate dehydrogenase Bos taurus 11-44 12615686-1 2003 OBJECTIVE: Glucose-6-phosphate dehydrogenase (G6PD), the principal source of NADPH, serves as an antioxidant enzyme to modulate the redox milieu and nitric oxide synthase activity. NADP 77-82 glucose-6-phosphate dehydrogenase Bos taurus 46-50 12615686-5 2003 METHODS AND RESULTS: Adenoviral-mediated gene transfer of G6PD increased G6PD expression, activity, and NADPH levels in bovine aortic endothelial cells (BAECs). NADP 104-109 glucose-6-phosphate dehydrogenase Bos taurus 58-62 11007790-4 2000 In this paper we show that increased glucose (10-25 mm) caused inhibition of G6PD resulting in decreased NADPH levels in bovine aortic endothelial cells (BAEC). NADP 105-110 glucose-6-phosphate dehydrogenase Bos taurus 77-81 669982-5 1978 The activity of the NADPH regenerating enzymes glucose-6-phosphate dehydrogenase and phosphogluconate dehydrogenase (decarboxylating), and the activity of acid hydrolases such as non-specific esterase and acid phosphatase is higher in the Purkinje fibers of both the bovine and porcine heart. NADP 20-25 glucose-6-phosphate dehydrogenase Bos taurus 47-80 18649867-6 1994 The enzymes analyzed were ATPase, which belongs to the transport mechanism in lens epithelium cells, hexokinase, the key enzyme of the glycolysis pathway, G6PD, which provides NADPH to the glutathione system and catalase, which protects the cells from H(2)O(2). NADP 176-181 glucose-6-phosphate dehydrogenase Bos taurus 155-159 17474-1 1977 Inhibition by aurinetricarboxylic acid (ATA) of glucose-6-phosphate (G6P) dehydrogenase was "competitive" with respect to G6P and "mixed type" with respect to NADP+. NADP 159-164 glucose-6-phosphate dehydrogenase Bos taurus 48-87 13673-3 1976 The ratios of the levels of the metabolites involved suggested that the reactions of the glucose-6-phosphate dehydrogenase and of the glutathione reductase operate dependent on the redox state of the triphosphopyridine nucleotides. NADP 200-230 glucose-6-phosphate dehydrogenase Bos taurus 89-122 31269353-9 2019 NADPH was positively correlated with TP (r=0.239, p(0.05), GPx (r=0.265, p(0.05) and G6PD (r=0.248, p=0.056). NADP 0-5 glucose-6-phosphate dehydrogenase Bos taurus 85-89 23709600-1 2013 The activity of glucose-6-phosphate dehydrogenase (G6PD) appears to control a vascular smooth muscle relaxing mechanism regulated through cytosolic NADPH oxidation. NADP 148-153 glucose-6-phosphate dehydrogenase Bos taurus 16-49 23709600-1 2013 The activity of glucose-6-phosphate dehydrogenase (G6PD) appears to control a vascular smooth muscle relaxing mechanism regulated through cytosolic NADPH oxidation. NADP 148-153 glucose-6-phosphate dehydrogenase Bos taurus 51-55 24375799-2 2014 This PKG-1alpha-activation mechanism appears to contribute to responses of isolated endothelium-removed bovine pulmonary arteries (BPA) elicited by peroxide, cytosolic NADPH oxidation resulting from G6PD inhibition, and hypoxia. NADP 168-173 glucose-6-phosphate dehydrogenase Bos taurus 199-203 23709600-9 2013 Thus regulation of cytosolic NADPH redox by G6PD appears to control PKG1alpha dimerization in BPA through its influence on Trx-1 redox regulation by the NADPH dependence of TrxR-1. NADP 29-34 glucose-6-phosphate dehydrogenase Bos taurus 44-48