PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25363737-6 2015 Its Nrf2 activity was evaluated by determining NADPH:quinone oxidoreductase-1 induction activity in Hepa1c1c7 cells. NADP 47-52 nuclear factor, erythroid derived 2, like 2 Mus musculus 4-8 32893883-9 2020 Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2. NADP 301-305 nuclear factor, erythroid derived 2, like 2 Mus musculus 38-42 32893883-9 2020 Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2. NADP 301-305 nuclear factor, erythroid derived 2, like 2 Mus musculus 222-226 32893883-9 2020 Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2. NADP 301-305 nuclear factor, erythroid derived 2, like 2 Mus musculus 222-226 26530903-3 2015 In this setting, Nrf2 expression conferred metabolic alterations in keratinocytes that were protumorigenic in nature, affecting enzymes involved in glutathione biosynthesis or in the oxidative pentose phosphate pathway and other NADPH-producing enzymes. NADP 229-234 nuclear factor, erythroid derived 2, like 2 Mus musculus 17-21 31128530-4 2019 In response to oxidative stress, Nrf2 translocates to the nucleus and binds to specific DNA sites termed as anti-oxidant response elements to initiate transcription of cytoprotective genes, such as hemeoxygenase-1 (HO-1) and nicotinamide adenine dinucleotide phosphate: quinine oxidoreductase-1 (NQO1). NADP 225-268 nuclear factor, erythroid derived 2, like 2 Mus musculus 33-37 26422507-4 2015 In the light of their sensitivity to genetic and pharmacological modulation of renal Nrf2 activity, genes/proteins that regulate xenobiotic disposition, redox balance, the intra/extracellular transport of small molecules, and the supply of NADPH and other cellular fuels were found to be positively regulated by Nrf2 in the kidney. NADP 240-245 nuclear factor, erythroid derived 2, like 2 Mus musculus 85-89 26422507-6 2015 In addition, the levels of NADPH and glutathione were found to be significantly decreased in the kidneys of Nrf2 knockout mice. NADP 27-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 108-112 21775727-0 2011 Beneficial role of Nrf2 in regulating NADPH generation and consumption. NADP 38-43 nuclear factor, erythroid derived 2, like 2 Mus musculus 19-23 24718857-5 2014 These cellular phenotypes were sustained by alterations in cellular redox homeostasis resulting from elevated expression of the reactive oxygen species-generating enzyme Nox4 [NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-4] and an impaired capacity to induce the Nrf2 (NFE2-related factor 2) antioxidant response. NADP 176-181 nuclear factor, erythroid derived 2, like 2 Mus musculus 294-298 24718857-5 2014 These cellular phenotypes were sustained by alterations in cellular redox homeostasis resulting from elevated expression of the reactive oxygen species-generating enzyme Nox4 [NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-4] and an impaired capacity to induce the Nrf2 (NFE2-related factor 2) antioxidant response. NADP 176-181 nuclear factor, erythroid derived 2, like 2 Mus musculus 300-321 21775727-6 2011 Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production. NADP 183-188 nuclear factor, erythroid derived 2, like 2 Mus musculus 98-102 21775727-6 2011 Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production. NADP 183-188 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-132 21775727-6 2011 Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production. NADP 183-188 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-132 21775727-8 2011 High performance liquid chromatography-ultraviolet absorbance analysis confirmed that hepatic NADPH concentration was lowest in Nrf2-null mice and highest in Keap1-HKO mice. NADP 94-99 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-132 21775727-10 2011 In conclusion, the present study suggests that Nrf2 protects against environmental insults by promoting the generation of NADPH, which is preferentially consumed by aiding scavenging of oxidative stress rather than fatty acid synthesis and desaturation. NADP 122-127 nuclear factor, erythroid derived 2, like 2 Mus musculus 47-51