PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25363737-6	2015	Its Nrf2 activity was evaluated by determining NADPH:quinone oxidoreductase-1 induction activity in Hepa1c1c7 cells.	NADP	47-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-8	
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	NADP	301-305	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-42	
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	NADP	301-305	nuclear factor, erythroid derived 2, like 2	Mus musculus	222-226	
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	NADP	301-305	nuclear factor, erythroid derived 2, like 2	Mus musculus	222-226	
26530903-3	2015	In this setting, Nrf2 expression conferred metabolic alterations in keratinocytes that were protumorigenic in nature, affecting enzymes involved in glutathione biosynthesis or in the oxidative pentose phosphate pathway and other NADPH-producing enzymes.	NADP	229-234	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21	
31128530-4	2019	In response to oxidative stress, Nrf2 translocates to the nucleus and binds to specific DNA sites termed as anti-oxidant response elements to initiate transcription of cytoprotective genes, such as hemeoxygenase-1 (HO-1) and nicotinamide adenine dinucleotide phosphate: quinine oxidoreductase-1 (NQO1).	NADP	225-268	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37	
26422507-4	2015	In the light of their sensitivity to genetic and pharmacological modulation of renal Nrf2 activity, genes/proteins that regulate xenobiotic disposition, redox balance, the intra/extracellular transport of small molecules, and the supply of NADPH and other cellular fuels were found to be positively regulated by Nrf2 in the kidney.	NADP	240-245	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89	
26422507-6	2015	In addition, the levels of NADPH and glutathione were found to be significantly decreased in the kidneys of Nrf2 knockout mice.	NADP	27-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112	
21775727-0	2011	Beneficial role of Nrf2 in regulating NADPH generation and consumption.	NADP	38-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23	
24718857-5	2014	These cellular phenotypes were sustained by alterations in cellular redox homeostasis resulting from elevated expression of the reactive oxygen species-generating enzyme Nox4 [NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-4] and an impaired capacity to induce the Nrf2 (NFE2-related factor 2) antioxidant response.	NADP	176-181	nuclear factor, erythroid derived 2, like 2	Mus musculus	294-298	
24718857-5	2014	These cellular phenotypes were sustained by alterations in cellular redox homeostasis resulting from elevated expression of the reactive oxygen species-generating enzyme Nox4 [NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-4] and an impaired capacity to induce the Nrf2 (NFE2-related factor 2) antioxidant response.	NADP	176-181	nuclear factor, erythroid derived 2, like 2	Mus musculus	300-321	
21775727-6	2011	Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production.	NADP	183-188	nuclear factor, erythroid derived 2, like 2	Mus musculus	98-102	
21775727-6	2011	Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production.	NADP	183-188	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132	
21775727-6	2011	Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production.	NADP	183-188	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132	
21775727-8	2011	High performance liquid chromatography-ultraviolet absorbance analysis confirmed that hepatic NADPH concentration was lowest in Nrf2-null mice and highest in Keap1-HKO mice.	NADP	94-99	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132	
21775727-10	2011	In conclusion, the present study suggests that Nrf2 protects against environmental insults by promoting the generation of NADPH, which is preferentially consumed by aiding scavenging of oxidative stress rather than fatty acid synthesis and desaturation.	NADP	122-127	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-51