PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33242213-3 2021 Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death. NADP 273-278 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 33354283-7 2020 As a nuclear factor E2-related factor 2 (Nrf2) agonist, TBHQ may inhibit neurotoxicity caused by oxidative stress through the following three mechanisms: the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system, the astrocytes activation, and the glutathione pathway. NADP 158-201 NFE2 like bZIP transcription factor 2 Homo sapiens 41-45 33242213-3 2021 Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death. NADP 273-278 NFE2 like bZIP transcription factor 2 Homo sapiens 147-151 33242213-3 2021 Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death. NADP 273-278 NFE2 like bZIP transcription factor 2 Homo sapiens 147-151 31575956-7 2019 Antioxidant enzymes transcriptionally regulated by Nrf2 and involved in GSH, NADPH, and NADH generation were significantly lower including PRX1 and PRX3, GPX4, GSTP1, GCLC, and MTHFD2. NADP 77-82 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 31712965-5 2020 It is becoming clear that Nrf2 is activated in a tissue-specific manner in response to mitochondrial or NADPH oxidase-generated ROS. NADP 104-109 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 27636396-5 2016 Dexamethasone promoted the nuclear accumulation of the transcription factor nuclear factor (erythroid-derived 2)-like 2 to drive expression of antioxidant pathways involved in GSH synthesis and NADPH production. NADP 194-199 NFE2 like bZIP transcription factor 2 Homo sapiens 76-119 31054074-7 2019 Stress-activated transcription factor Nrf2 regulates the pathways to protect cells against oxidative stress and metabolic pathways initiating the NADPH and ATP production. NADP 146-151 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 30236989-5 2018 Nrf2 has been involved in maintaining mitochondrial redox homeostasis by providing reduced forms of glutathione (GSH); the reducing cofactor NADPH; and mitochondrial antioxidant enzymes such as GSH peroxidase 1, superoxide dismutase 2, and peroxiredoxin 3/5. NADP 141-146 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 27789056-5 2017 Both global and tubular-specific Nrf2 activation enhanced gene expression of antioxidant and NADPH synthesis enzymes, including glucose-6-phosphate dehydrogenase, and ameliorated both the initiation of injury in the outer medulla and the progression of tubular damage in the cortex. NADP 93-98 NFE2 like bZIP transcription factor 2 Homo sapiens 33-37 27789056-9 2017 These findings demonstrate that tubular hyperactivation of Nrf2 in the initial phase of injury prevents the progression of reactive oxygen species-mediated tubular damage by inducing antioxidant enzymes and NADPH synthesis. NADP 207-212 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 28899199-3 2018 Recent Advances: Nrf2 regulates the transcription of components of the glutathione and thioredoxin antioxidant systems, as well as enzymes involved in phase I and phase II detoxification of exogenous and endogenous products, NADPH regeneration, and heme metabolism. NADP 225-230 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 24647116-4 2014 In the latter case, Nrf2 inhibits lipogenesis, supports beta-oxidation of fatty acids, facilitates flux through the pentose phosphate pathway, and increases NADPH regeneration and purine biosynthesis; these observations suggest Nrf2 directs metabolic reprogramming during stress. NADP 157-162 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 25975984-2 2015 Nrf2 has a crucial role in the maintenance of cellular redox homeostasis by regulating the biosynthesis, utilization, and regeneration of glutathione, thioredoxin, and NADPH and by controlling the production of reactive oxygen species by mitochondria and NADPH oxidase. NADP 168-173 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 24647116-4 2014 In the latter case, Nrf2 inhibits lipogenesis, supports beta-oxidation of fatty acids, facilitates flux through the pentose phosphate pathway, and increases NADPH regeneration and purine biosynthesis; these observations suggest Nrf2 directs metabolic reprogramming during stress. NADP 157-162 NFE2 like bZIP transcription factor 2 Homo sapiens 228-232 17303087-5 2007 Specific silence of Nrf2 by siRNA down-regulated tanshinone IIA-induced Nrf2 activation and increased of intracellular GSH, NADPH and G6PDH levels. NADP 124-129 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 23729024-9 2013 The effectiveness of miltefosine for positive induction of ROS via NADPH correlated with a decrease in HO-1/ERK/Nrf-2-dependent parasite load. NADP 67-72 NFE2 like bZIP transcription factor 2 Homo sapiens 112-117 24024172-5 2013 Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1. NADP 77-82 NFE2 like bZIP transcription factor 2 Homo sapiens 196-200 24342878-9 2013 Interestingly, a large fraction of these AOS genes are downstream targets of the transcription factors NRF2, NF-kappaB and FOXM1, and relay on NADPH for their enzymatic activities highlighting promising drug targets. NADP 143-148 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 24024172-4 2013 Upon Nrf2 activation glucose is preferentially metabolized through the pentose phosphate pathway with increased production of NADPH. NADP 126-131 NFE2 like bZIP transcription factor 2 Homo sapiens 5-9 24024172-5 2013 Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1. NADP 77-82 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 23390006-2 2013 This study aims to clarify the molecular mechanisms how 6-MTITC modulates nuclear factor E2-related factor 2 (Nrf2)/Kelchlike ECH-associating protein 1 (Keap1) system in antioxidant-responsive element (ARE)-mediated nicotinamide adenine dinucleotide phosphate (NADP): quinone oxidoreductase 1 (NQO1) expression. NADP 216-259 NFE2 like bZIP transcription factor 2 Homo sapiens 110-114 23390006-2 2013 This study aims to clarify the molecular mechanisms how 6-MTITC modulates nuclear factor E2-related factor 2 (Nrf2)/Kelchlike ECH-associating protein 1 (Keap1) system in antioxidant-responsive element (ARE)-mediated nicotinamide adenine dinucleotide phosphate (NADP): quinone oxidoreductase 1 (NQO1) expression. NADP 261-265 NFE2 like bZIP transcription factor 2 Homo sapiens 110-114 22445099-8 2012 Although Nrf2-dependent antioxidant proteins (thioredoxin-1 [Trx-1], nicotinamide adenine dinucleotide phosphate [NAD(P)H] quinone oxidoreductase [NQO1], glutathione S-transferase [GST]) were upregulated, heme oxygenase (HO-1) and adiponectin protein expression were lower in the diabetic group (P < 0.05). NADP 69-112 NFE2 like bZIP transcription factor 2 Homo sapiens 9-13 26122708-4 2015 In addition to cytoprotection, Nrf2 also controls genes involved in intermediary metabolism, positively regulating those involved in NADPH generation, purine biosynthesis, and the beta-oxidation of fatty acids, while suppressing those involved in lipogenesis and gluconeogenesis. NADP 133-138 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 15872021-7 2005 We provide evidence that dysregulation of Nrf2 and the ARE, coupled with reduced pentose phosphate pathway activity and decreased generation of NADPH, represent significant and hitherto unrecognized components of the toxic gain of function of mutant SOD1. NADP 144-149 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 12556532-7 2003 In support of these observations, we identified Nrf2-dependent genes encoding detoxification enzymes, glutathione-related proteins, antioxidant proteins, NADPH-producing enzymes, and anti-inflammatory genes using oligonucleotide microarrays. NADP 154-159 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 26122708-16 2015 By contrast, too much Nrf2 activity disturbs the homeostatic balance in favor of reduction, and so may have deleterious consequences including overproduction of reduced glutathione and NADPH, the blunting of ROS-based signal transduction, epithelial cell hyperplasia, and failure of certain cell types to differentiate correctly. NADP 185-190 NFE2 like bZIP transcription factor 2 Homo sapiens 22-26 34151236-4 2021 Mechanistically, KEAP1 inactivation in lung cancer cells induces constitutive activation of NRF2 transcription factor and aberrant expression of NRF2 target cystine transporter SLC7A11; under glucose limitation, high cystine uptake in KEAP1-inactivated lung cancer cells stimulates toxic intracellular disulfide buildup, NADPH depletion, and cell death, which can be rescued by genetic ablation of NRF2-SLC7A11 axis or treatments inhibiting disulfide accumulation. NADP 321-326 NFE2 like bZIP transcription factor 2 Homo sapiens 145-149