PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2643484-6 1989 Nuclear protein fractionation studies revealed CB of CCl4 reactive metabolites to both histone and non-histone proteins when nuclear preparations activated CCl4 either in the presence or absence of NADPH. NADP 198-203 C-C motif chemokine ligand 4 Rattus norvegicus 53-57 3420612-6 1988 At CCl4 concentrations of 1 mM and greater, the NADPH-dependent activation of PLC by CCl4 is reduced because CCl4 biotransformation is inhibited. NADP 48-53 C-C motif chemokine ligand 4 Rattus norvegicus 3-7 3420612-6 1988 At CCl4 concentrations of 1 mM and greater, the NADPH-dependent activation of PLC by CCl4 is reduced because CCl4 biotransformation is inhibited. NADP 48-53 C-C motif chemokine ligand 4 Rattus norvegicus 85-89 3420612-6 1988 At CCl4 concentrations of 1 mM and greater, the NADPH-dependent activation of PLC by CCl4 is reduced because CCl4 biotransformation is inhibited. NADP 48-53 C-C motif chemokine ligand 4 Rattus norvegicus 85-89 3377806-2 1988 Stoichiometric losses of microsomal haem and cytochrome P-450 were observed when carbon tetrachloride (CCl4) was incubated anaerobically with rat liver microsomes using NADPH or sodium dithionite as a reducing agent. NADP 169-174 C-C motif chemokine ligand 4 Rattus norvegicus 103-107 6666676-8 1983 In vitro disappearance of GSH added to the liver homogenate from CCl4-treated rats occurred enzymatically and could not be prevented by the addition of a NADPH-generating system. NADP 154-159 C-C motif chemokine ligand 4 Rattus norvegicus 65-69 6099695-3 1984 The enzymatic mitochondrial CCl4 activation operates more efficiently under anaerobic conditions; it requires NADPH, is CO sensitive, is inducible by phenobarbital pretreatment and is only weakly inhibited by high concentrations of cyanide or azide. NADP 110-115 C-C motif chemokine ligand 4 Rattus norvegicus 28-32 6477950-3 1984 Under these conditions, at the hypoxic end of the physiological PO2 in liver, CCl4 caused a 5-fold increase in the oxygen uptake rate and a 20-fold increase in the malondialdehyde formation rate while, at 80 mmHg (10.7 kPa) the haloalkane caused only an increase of 2- and 4-fold, respectively; in comparison, there was only a slight increase in NADPH-induced lipid peroxidation with increasing PO2. NADP 346-351 C-C motif chemokine ligand 4 Rattus norvegicus 78-82 6661232-3 1983 For example, 1,1-dichloro-2,2,3,3-tetramethylcyclopropane was identified as a metabolite by gas chromatography mass spectrometry when carbon tetrachloride (CCl4) was incubated anaerobically with rat liver microsomes, NADPH and 2,3-dimethyl-2-butene. NADP 217-222 C-C motif chemokine ligand 4 Rattus norvegicus 156-160 7360993-1 1980 Rat liver microsomal lipid peroxidation as measured by malondialdehyde formation induced by the NADPH-dependent metabolism of CCl4 led to a concomitant lysis of erythrocytes added to the incubation mixture. NADP 96-101 C-C motif chemokine ligand 4 Rattus norvegicus 126-130 7082331-2 1982 Data are also presented which show that this form of cytochrome P-450 was capable of generating the trichloromethyl radical from CCl4 in a reconstituted system containing the purified cytochrome, NADPH-cytochrome P-450 reductase, NADPH, CCl4, and the spin-trapping agent, phenyl-t-butyl nitrone. NADP 196-201 C-C motif chemokine ligand 4 Rattus norvegicus 129-133 7082331-2 1982 Data are also presented which show that this form of cytochrome P-450 was capable of generating the trichloromethyl radical from CCl4 in a reconstituted system containing the purified cytochrome, NADPH-cytochrome P-450 reductase, NADPH, CCl4, and the spin-trapping agent, phenyl-t-butyl nitrone. NADP 196-201 C-C motif chemokine ligand 4 Rattus norvegicus 237-241 7071415-4 1982 CCl3 by an NADPH anaerobic liver microsomal activation of CCl4, covalently binds to heme and heme degradation products from CO-binding particles. NADP 11-16 C-C motif chemokine ligand 4 Rattus norvegicus 58-62 6620724-4 1983 Ca++ increased the Fe++-induced NADPH-dependent lipid peroxidation in hepatic microsomes, and this Ca++ effect was also enhanced by CCl4 treatment. NADP 32-37 C-C motif chemokine ligand 4 Rattus norvegicus 132-136 6620724-5 1983 These results suggest that the increment of hepatic lipid peroxidation following CCl4 administration may be, at least in part, due to the increment of Fe++-induced NADPH-dependent lipid peroxidation by Ca++, and the taurine pretreatment may affect the increase by increasing Ca++ content in the liver. NADP 164-169 C-C motif chemokine ligand 4 Rattus norvegicus 81-85 16702-0 1977 The effects of CCl4 on the content of nicotinamide adenine dinucleotide phosphate in rat liver. NADP 38-81 C-C motif chemokine ligand 4 Rattus norvegicus 15-19 7699199-4 1994 When the effect of changing the concentrations of CCl4, PBN or NADPH-generating system was investigated, the plots of EPR signal intensity vs. the variable selected showed initial smooth increases in signal strength with respect to an increase in concentrations of CCl4, PBN or NADPH-generating system. NADP 63-68 C-C motif chemokine ligand 4 Rattus norvegicus 265-269 25299839-9 2014 Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH. NADP 165-170 C-C motif chemokine ligand 4 Rattus norvegicus 59-63 9525102-1 1998 Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2"-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. NADP 174-179 C-C motif chemokine ligand 4 Rattus norvegicus 180-184 9342944-5 1997 When the lipid peroxidation was induced by incubating rat liver microsomes with CCl4 in the presence of NADPH, the standardized saponin significantly blocked the formation of thiobarbituric acid-reactive substances at the same concentrations showing P450 inhibition in liver microsomes. NADP 104-109 C-C motif chemokine ligand 4 Rattus norvegicus 80-84 8961948-4 1996 In the presence of NADPH, CCl4 produced a concentration-dependent release of calcium from liver microsomes after a lag period. NADP 19-24 C-C motif chemokine ligand 4 Rattus norvegicus 26-30 8961948-7 1996 Inhibition of the CCl4-induced release of calcium by 4-methylpyrazole and by anti-CYP2E1 IgG, and the requirement for NADPH, indicates that CCl4 metabolism is required for the activation of calcium release. NADP 118-123 C-C motif chemokine ligand 4 Rattus norvegicus 18-22 8961948-7 1996 Inhibition of the CCl4-induced release of calcium by 4-methylpyrazole and by anti-CYP2E1 IgG, and the requirement for NADPH, indicates that CCl4 metabolism is required for the activation of calcium release. NADP 118-123 C-C motif chemokine ligand 4 Rattus norvegicus 140-144 7699199-4 1994 When the effect of changing the concentrations of CCl4, PBN or NADPH-generating system was investigated, the plots of EPR signal intensity vs. the variable selected showed initial smooth increases in signal strength with respect to an increase in concentrations of CCl4, PBN or NADPH-generating system. NADP 278-283 C-C motif chemokine ligand 4 Rattus norvegicus 265-269 1311644-3 1992 Microsomes isolated from P-450IIE1-induced liver were also much more effective at catalysing a NADPH-dependent metabolism of CCl4 and DMN. NADP 95-100 C-C motif chemokine ligand 4 Rattus norvegicus 125-129 8091017-2 1994 It was observed that the activities of serum marker enzymes, hepatic enzymes and NADPH-dependent lipid peroxidation were significantly elevated after treatment with CCl4. NADP 81-86 C-C motif chemokine ligand 4 Rattus norvegicus 165-169 7879294-4 1994 Application of "Kalmofil" in vivo under experimental rat hepatitis provoked by CCl4 has a corrective effect on both nonenzymatic and Fe(2+)- and NADP.H-depending LPO reactions. NADP 145-149 C-C motif chemokine ligand 4 Rattus norvegicus 79-83 8303091-2 1993 We demonstrate the occurrence of NADPH-dependent CCl4-promoted lipid peroxidation processes (LP) leading to malondialdehyde (MDA) formation in liver microsomal and nuclear preparations from OM and SD rats which do not correlate with the cancer susceptibility of both strains. NADP 33-38 C-C motif chemokine ligand 4 Rattus norvegicus 49-53 1311644-5 1992 The P-450IIE1 antibody markedly inhibited the NADPH-dependent metabolism of these compounds indicating that IIE1 is a major catalyst of the microsomal metabolism of CCl4 and DMN. NADP 46-51 C-C motif chemokine ligand 4 Rattus norvegicus 165-169 1790244-4 1991 The control of microsomal membrane stability against Fe(2+)-ADP, NADPH-induced LPO, after being isolated from rat liver after the action of CCl4 without and with DECC, showed that DECC protected microsomal membranes from CCl4 in vivo and they remained stable against LPO in vitro. NADP 65-70 C-C motif chemokine ligand 4 Rattus norvegicus 221-225 1654287-6 1991 A high correlation (r = 0.947) was indicated between the percent inhibition of nucleotide pyrophosphatase and the percent synergism of NADPH-catalyzed CCl4 metabolism. NADP 135-140 C-C motif chemokine ligand 4 Rattus norvegicus 151-155 1654287-7 1991 Thus, pyridine nucleotide synergism in CCl4 metabolism appears to result from the increased availability of NADPH produced by a decreased degradation of the NADPH by the nucleotide pyrophosphatase. NADP 108-113 C-C motif chemokine ligand 4 Rattus norvegicus 39-43 1654287-7 1991 Thus, pyridine nucleotide synergism in CCl4 metabolism appears to result from the increased availability of NADPH produced by a decreased degradation of the NADPH by the nucleotide pyrophosphatase. NADP 157-162 C-C motif chemokine ligand 4 Rattus norvegicus 39-43 2140358-0 1990 The in vitro NADPH-dependent inhibition by CCl4 of the ATP-dependent calcium uptake of hepatic microsomes from male rats. NADP 13-18 C-C motif chemokine ligand 4 Rattus norvegicus 43-47 2140358-5 1990 We have now found in in vitro incubations that CCl4 (0.5-2.5 mM) enhanced the NADPH-dependent inhibition of Ca2+ uptake from 28% without CCl4 to a maximum of 68%. NADP 78-83 C-C motif chemokine ligand 4 Rattus norvegicus 47-51 2140358-5 1990 We have now found in in vitro incubations that CCl4 (0.5-2.5 mM) enhanced the NADPH-dependent inhibition of Ca2+ uptake from 28% without CCl4 to a maximum of 68%. NADP 78-83 C-C motif chemokine ligand 4 Rattus norvegicus 137-141 2140358-17 1990 The NADPH-dependent CCl4 inhibition was greater under N2 and was totally prevented by CO. NADP 4-9 C-C motif chemokine ligand 4 Rattus norvegicus 20-24 2390286-5 1990 NADH-catalyzed CCl4 metabolism occurred to a similar extent in control and PB microsomes, amounting to 9-10% and 5-6% of the NADPH rate in control and PB microsomes, respectively. NADP 125-130 C-C motif chemokine ligand 4 Rattus norvegicus 15-19 2390286-8 1990 Thus, the synergistic increase in CCl4 metabolism produced by NADH may occur in part from an increased availability of NADPH, as a result of decreased degradation, rather than by electron donation from NADH. NADP 119-124 C-C motif chemokine ligand 4 Rattus norvegicus 34-38