PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9545283-1 1998 The leukocyte NADPH oxidase is an enzyme in phagocytes and B lymphocytes that when activated catalyzes the production of O-2 from oxygen and NADPH. NADP 14-19 immunoglobulin kappa variable 1D-39 Homo sapiens 121-124 9851827-1 1998 The leukocyte NADPH oxidase of neutrophils is a membrane-bound enzyme that catalyzes the production of O-2 from oxygen using NADPH as the electron donor. NADP 14-19 immunoglobulin kappa variable 1D-39 Homo sapiens 103-106 9748657-1 1998 The leukocyte NADPH oxidase of neutrophils is a membrane-bound enzyme that catalyzes the production of O-2 from oxygen using NADPH as the electron donor. NADP 14-19 immunoglobulin kappa variable 1D-39 Homo sapiens 103-106 10336447-1 1999 The leukocyte NADPH oxidase is an enzyme present in phagocytes and B lymphocytes that when activated catalyzes the production of O-2 from oxygen at the expense of NADPH. NADP 14-19 immunoglobulin kappa variable 1D-39 Homo sapiens 129-132 9712892-6 1998 In the presence of NADPH, prominent O-2 adduct signals were detected from iNOS. NADP 19-24 immunoglobulin kappa variable 1D-39 Homo sapiens 36-39 6096475-10 1984 Possible changes in the enzyme responsible for the oxidative burst were analyzed by studying NADPH-dependent generation of O-2 by particulate fractions from cells preincubated with LPS or buffer, then stimulated before cell disruption. NADP 93-98 immunoglobulin kappa variable 1D-39 Homo sapiens 123-126 9148950-1 1997 The elicitation of an oxidative burst in phagocytes rests on the assembly of a multicomponental complex (NADPH oxidase) consisting of a membrane-associated flavocytochrome (cytochrome b559), representing the redox element responsible for the NADPH-dependent reduction of oxygen to superoxide (O-2), two cytosolic components (p47(phox), p67(phox)), and the small GTPase Rac (1 or 2). NADP 105-110 immunoglobulin kappa variable 1D-39 Homo sapiens 293-296 2423606-4 1986 Because intermediates of the phosphatidylinositol cycle, via increases in available calcium levels or activated protein kinase C, are considered potential second messengers for activation of the NADPH-dependent O-2-generating system, we compared neutrophil responses to gamma-hexachlorocyclohexane with responses to phorbol myristate acetate, an activator of protein kinase C with well known effects on neutrophils. NADP 195-200 immunoglobulin kappa variable 1D-39 Homo sapiens 211-214 6096475-11 1984 The fraction prepared from LPS-pretreated neutrophils exhibited greater release of O-2 over a wide range of concentrations of NADPH. NADP 126-131 immunoglobulin kappa variable 1D-39 Homo sapiens 83-86 6832359-4 1983 The fate of the proton produced in the reaction NADPH + 2 O2 leads to NADP + 2 O-2 + H+ is also discussed in light of our model. NADP 48-53 immunoglobulin kappa variable 1D-39 Homo sapiens 79-82 6832359-4 1983 The fate of the proton produced in the reaction NADPH + 2 O2 leads to NADP + 2 O-2 + H+ is also discussed in light of our model. NADP 48-52 immunoglobulin kappa variable 1D-39 Homo sapiens 79-82 6295497-1 1982 A system, which contains NADPH, purified cytochrome P-450 reductase and adriamycin, produces H2O2, O-2 and adriamycin semiquinone radical with O2 consumption and NADPH oxidation. NADP 25-30 immunoglobulin kappa variable 1D-39 Homo sapiens 93-102 6295497-1 1982 A system, which contains NADPH, purified cytochrome P-450 reductase and adriamycin, produces H2O2, O-2 and adriamycin semiquinone radical with O2 consumption and NADPH oxidation. NADP 162-167 immunoglobulin kappa variable 1D-39 Homo sapiens 93-102 6295574-3 1982 Also involved in the O-.2-forming reaction is a b-type cytochrome; the role of this cytochrome is as yet undefined, though it does not appear to be on the direct route of electron transfer between NADPH and oxygen. NADP 197-202 immunoglobulin kappa variable 1D-39 Homo sapiens 21-25 23176-5 1978 The rate of O-2 generation in the particulate fraction was higher in the presence of NADPH than in the presence of NADH. NADP 85-90 immunoglobulin kappa variable 1D-39 Homo sapiens 12-15