PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 564083-1 1977 A double-immunodiffusion method has been developed to detect human mitochondrial NADP-linked isocitrate dehydrogenase (EC 1.1.1.42; designated as IDH-2) using rabbit antiserum against the relevant enzyme. NADP 81-85 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 146-151 11278619-6 2001 The protective role of IDPm against oxidative damage may be attributed to increased levels of a reducing equivalent, NADPH, needed for regeneration of glutathione in the mitochondria. NADP 117-122 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 23-27 11278619-7 2001 Our results strongly indicate that IDPm is a major NADPH producer in the mitochondria and thus plays a key role in cellular defense against oxidative stress-induced damage. NADP 51-56 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 35-39 8954790-0 1996 Assignment of the human mitochondrial NADP(+)-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization. NADP 38-42 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 81-85 32900482-2 2020 Maintenance of mitochondrial redox balance status requires NADPH, which is primarily generated by the mitochondrial matrix protein isocitrate dehydrogenase 2 (IDH2). NADP 59-64 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 131-157 32900482-2 2020 Maintenance of mitochondrial redox balance status requires NADPH, which is primarily generated by the mitochondrial matrix protein isocitrate dehydrogenase 2 (IDH2). NADP 59-64 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 159-163 32900482-7 2020 Mutation of the SUMOylation site impairs the enzymatic activity of IDH2 and hence decreases levels of alpha-ketoglutarate (alpha-KG), NADPH and GSH. NADP 134-139 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 67-71 32955829-1 2020 The isocitrate dehydrogenases enzymes, IDH1 and IDH2, catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG) in the cell cytoplasm and mitochondria, respectively, and contribute to generating the dihydronicotinamide-adenine dinucleotide phosphate (NADPH) as reductive potential in different cellular processes. NADP 212-262 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 48-52 32955829-1 2020 The isocitrate dehydrogenases enzymes, IDH1 and IDH2, catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG) in the cell cytoplasm and mitochondria, respectively, and contribute to generating the dihydronicotinamide-adenine dinucleotide phosphate (NADPH) as reductive potential in different cellular processes. NADP 264-269 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 48-52 29184081-4 2017 Here, we report the results from computational studies that AGI-6780 binds tightly with the divalent cation binding helices at the homodimer interface and prevents the transition of IDH2/R140Q homodimer to a closed conformation that is required for catalysis, resulting in the decrease of the binding free energy of NADPHs. NADP 316-322 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 182-186 32777735-3 2020 Cancer-associated substitutions in IDH1 and IDH2 impair wild-type production of 2-oxoglutarate and reduced nicotinamide adenine dinucleotide phosphate (NADPH) from isocitrate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+ ), and substantially promote the IDH variant catalysed conversion of 2-oxoglutarate to d-2-hydroxyglutarate (d-2HG). NADP 233-238 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 44-48 28653623-4 2017 Conversely, expression of R172K mutant IDH2 resulted in increased alpha-ketoglutarate-dependent consumption of NADPH compared to wild-type IDH2 or vector control. NADP 111-116 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 39-43 28267914-13 2017 Only IDH2 NADP+ activity was shown to be inhibited directly. NADP 10-14 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 5-9 28375741-2 2017 The three IDH isoforms (nicotinamide adenine dinucleotide phosphate-dependent IDH1 and IDH2, and nicotinamide adenine dinucleotide-dependent IDH3) contribute to regulating the circuitry of central metabolism. NADP 24-67 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 87-91 27113762-3 2016 Here, we report that SIRT5 desuccinylates and deglutarylates isocitrate dehydrogenase 2 (IDH2) and glucose-6-phosphate dehydrogenase (G6PD), respectively, and thus activates both NADPH-producing enzymes. NADP 179-184 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 89-93 26865387-2 2017 We recently showed that mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) functions as an antioxidant and anti-apoptotic protein by supplying NADPH to antioxidant systems. NADP 154-159 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 80-84 27113762-4 2016 Moreover, we show that knockdown or knockout of SIRT5 leads to high levels of cellular ROS SIRT5 inactivation leads to the inhibition of IDH2 and G6PD, thereby decreasing NADPH production, lowering GSH, impairing the ability to scavenge ROS, and increasing cellular susceptibility to oxidative stress. NADP 171-176 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 137-141 27113762-5 2016 Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH2 desuccinylation and G6PD deglutarylation. NADP 71-76 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 122-126 28480226-8 2016 Our results demonstrate that wild type and mutant IDH1 or IDH2 heterodimers display similar physiological characteristics to that of mutant IDH1 or IDH2 homodimers with the exception of their ability to generate NADPH. NADP 212-217 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 58-62 27355333-3 2016 The mutated IDH1 and IDH2 proteins have a gain-of-function, neomorphic activity, catalyzing the reduction of alpha-ketoglutarate (alpha-KG) to 2-hydroxyglutarate (2-HG) by NADPH. NADP 172-177 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 21-25 28480226-8 2016 Our results demonstrate that wild type and mutant IDH1 or IDH2 heterodimers display similar physiological characteristics to that of mutant IDH1 or IDH2 homodimers with the exception of their ability to generate NADPH. NADP 212-217 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 148-152 26774511-10 2016 In support of this concept, the expression of GCLC (which codes for the rate-limiting enzyme in GSH synthesis) and genes which generate reducing equivalents in the form of NADPH (ie, G6PD, PGD, IDH2) are elevated in 1,25D-treated cells. NADP 172-177 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 194-198 26819452-1 2016 IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. NADP 149-154 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 9-13 26819452-1 2016 IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. NADP 149-154 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 209-213 26819452-1 2016 IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. NADP 149-153 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 9-13 26819452-1 2016 IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. NADP 149-153 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 209-213 24747768-7 2014 One such difference concerns mutations in the NADP(+)-dependent isocitrate dehydrogenase (IDH1 and IDH2) genes, which occur in >80% of cases of low grade glioma and secondary glioblastoma. NADP 46-50 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 99-103 24880135-5 2014 In their wild-type forms, IDH1 and IDH2 convert isocitrate and NADP(+) to alpha-ketoglutarate (alphaKG) and NADPH. NADP 63-70 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 35-39 24880135-5 2014 In their wild-type forms, IDH1 and IDH2 convert isocitrate and NADP(+) to alpha-ketoglutarate (alphaKG) and NADPH. NADP 108-113 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 35-39 24642088-4 2014 HAECs treated with 7-KC showed significant reductions of IDH2 mRNA and protein levels and enzyme activity, leading to decreased NADPH concentration and an increased ratio of reduced-to-oxidized glutathione in the mitochondria. NADP 128-133 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 57-61 23226729-1 2012 IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP(+)) to NADPH and participates in the citric acid cycle for energy production. NADP 117-160 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 23949315-1 2013 NADP-dependent enzyme isocitrate dehydrogenase (IDH) mutations, IDH1 and IDH2, have been described in acute myeloid leukemia (AML) using next generation sequencing approaches. NADP 0-4 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 73-77 22899282-1 2012 Monoallelic point mutations of the NADP(+)-dependent isocitrate dehydrogenases IDH1 and IDH2 occur frequently in gliomas, acute myeloid leukemias, and chondromas, and display robust association with specific DNA hypermethylation signatures. NADP 35-39 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 88-92 23876293-1 2013 BACKGROUND: There are three isocitrate dehydrogenases (IDHs) in the pancreatic insulin cell; IDH1 (cytosolic) and IDH2 (mitochondrial) use NADP(H). NADP 139-143 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 114-118 23500467-2 2013 Recently, we demonstrated that the control of mitochondrial redox balance and the cellular defense against oxidative damage are primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) via the supply of NADPH for antioxidant systems. NADP 163-170 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 207-211 23500467-2 2013 Recently, we demonstrated that the control of mitochondrial redox balance and the cellular defense against oxidative damage are primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) via the supply of NADPH for antioxidant systems. NADP 231-236 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 207-211 23226729-1 2012 IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP(+)) to NADPH and participates in the citric acid cycle for energy production. NADP 162-166 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 23226729-1 2012 IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP(+)) to NADPH and participates in the citric acid cycle for energy production. NADP 174-179 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 22106302-6 2011 Glutamine-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-linked mitochondrial isocitrate dehydrogenase (IDH2) to form isocitrate, which can then be isomerized to citrate. NADP 73-78 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 126-130 22197820-2 2012 In this paper, we demonstrate that the knockdown of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm), a mitochondrial NADPH-generating enzyme, by small interfering RNA (siRNA) enhanced BFA-induced apoptosis. NADP 66-73 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 110-114 22197820-2 2012 In this paper, we demonstrate that the knockdown of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm), a mitochondrial NADPH-generating enzyme, by small interfering RNA (siRNA) enhanced BFA-induced apoptosis. NADP 133-138 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 110-114 22675360-2 2012 IDH2 acts in the forward Krebs cycle as an NADP(+)-consuming enzyme, providing NADPH for maintenance of the reduced glutathione and peroxiredoxin systems and for self-maintenance by reactivation of cystine-inactivated IDH2 by glutaredoxin 2. NADP 43-50 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 22675360-2 2012 IDH2 acts in the forward Krebs cycle as an NADP(+)-consuming enzyme, providing NADPH for maintenance of the reduced glutathione and peroxiredoxin systems and for self-maintenance by reactivation of cystine-inactivated IDH2 by glutaredoxin 2. NADP 43-50 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 218-222 22675360-2 2012 IDH2 acts in the forward Krebs cycle as an NADP(+)-consuming enzyme, providing NADPH for maintenance of the reduced glutathione and peroxiredoxin systems and for self-maintenance by reactivation of cystine-inactivated IDH2 by glutaredoxin 2. NADP 79-84 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 22675360-4 2012 Reductive carboxylation of 2-oxoglutarate by IDH2 (in the reverse Krebs cycle direction), which consumes NADPH, may follow glutaminolysis of glutamine to 2-oxoglutarate in cancer cells. NADP 105-110 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 45-49 21647152-1 2011 Mutations in the NADP(+)-dependent isocitrate dehydrogenase genes 1 and 2 (IDH1 and IDH2) have recently been found in adult acute myeloid leukemia (AML) patients with a prevalence rising up to 33%. NADP 17-21 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 84-88 22002076-1 2011 PURPOSE OF REVIEW: Isocitrate dehydrogenases, IDH1 and IDH2, decarboxylate isocitrate to alpha-ketoglutarate (alpha-KG) and reduce NADP to NADPH. NADP 131-135 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 55-59 22002076-1 2011 PURPOSE OF REVIEW: Isocitrate dehydrogenases, IDH1 and IDH2, decarboxylate isocitrate to alpha-ketoglutarate (alpha-KG) and reduce NADP to NADPH. NADP 139-144 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 55-59 21741430-2 2011 Over the last several years, we have shown that the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) functions as an antioxidant and anti-apoptotic protein by supplying NADPH to antioxidant systems. NADP 66-73 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 110-114 21741430-2 2011 Over the last several years, we have shown that the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) functions as an antioxidant and anti-apoptotic protein by supplying NADPH to antioxidant systems. NADP 184-189 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 110-114 21326614-1 2011 BACKGROUND: Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). NADP 68-72 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 183-187 21641335-4 2011 IDH1 and IDH2 mutations lead to simultaneous loss and gain of activities in the production of alpha-ketoglutarate (alpha-KG) and 2-hydroxyglutarate (2HG), respectively, and result in lowering NADPH levels even further. NADP 192-197 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 9-13 21110780-2 2011 It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidant systems. NADP 48-52 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 92-96 21110780-2 2011 It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidant systems. NADP 171-176 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 92-96 21289278-1 2011 Point mutations of the NADP(+)-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) occur early in the pathogenesis of gliomas. NADP 23-27 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 85-89 20603105-1 2010 Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+to NADPH). NADP 147-190 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 66-70 20713124-2 2010 In the current study, small interfering RNA (siRNA)-mediated knockdown of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) suppressed hypoxia-induced stimulation of HIF-1alpha protein expression in PC3 human prostate cancer cells. NADP 88-92 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 132-136 20421455-1 2010 Mutations in the nicotinamide adenine dinucleotide phosphate(+)-dependent isocitrate dehydrogenase gene 2 (IDH2) have recently been found in patients with acute myeloid leukemia (AML) as well as in patients with leukemic transformation of myeloproliferative neoplasms. NADP 17-60 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 107-111 20603105-1 2010 Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+to NADPH). NADP 192-197 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 66-70 20603105-1 2010 Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+to NADPH). NADP 200-205 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 66-70 19500645-2 2009 We previously reported that control of the mitochondrial redox balance and the cellular defense against oxidative damage are primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) through to supply NADPH for antioxidant systems. NADP 160-166 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 204-208 20142433-8 2010 Recombinant IDH1 R132C and IDH2 R172K proteins catalyze the novel nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of alpha-ketoglutarate (alpha-KG) to 2-HG. NADP 66-109 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 27-31 20142433-8 2010 Recombinant IDH1 R132C and IDH2 R172K proteins catalyze the novel nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of alpha-ketoglutarate (alpha-KG) to 2-HG. NADP 111-116 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 27-31 20088709-3 2010 It has previously been reported that control of the mitochondrial redox balance is a primary function of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) by supplying NADPH for antioxidant systems. NADP 119-126 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 163-167 20088709-3 2010 It has previously been reported that control of the mitochondrial redox balance is a primary function of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) by supplying NADPH for antioxidant systems. NADP 182-187 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 163-167 19500645-2 2009 We previously reported that control of the mitochondrial redox balance and the cellular defense against oxidative damage are primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) through to supply NADPH for antioxidant systems. NADP 228-233 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 204-208 19228619-8 2009 CONCLUSIONS: Mutations of NADP(+)-dependent isocitrate dehydrogenases encoded by IDH1 and IDH2 occur in a majority of several types of malignant gliomas. NADP 26-30 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 90-94 17350954-2 2007 By supplying NADPH for antioxidant systems, we recently demonstrated that the control of mitochondrial redox balance and the cellular defense against oxidative damage are some of the primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm). NADP 13-18 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 262-266 18096511-2 2008 Mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) produces NADPH, an essential reducing equivalent for the antioxidant system. NADP 73-78 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 58-62 17854715-2 2007 Recently, we demonstrated that the control of mitochondrial redox balance and the cellular defense against oxidative damage is one of the primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) by supplying NADPH for antioxidant systems. NADP 236-241 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 217-221 18484410-3 2008 Recently, it was demonstrated that the control of mitochondrial redox balance and oxidative damage is one of the primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) to supply NADPH for antioxidant systems. NADP 148-155 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 192-196 18484410-3 2008 Recently, it was demonstrated that the control of mitochondrial redox balance and oxidative damage is one of the primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) to supply NADPH for antioxidant systems. NADP 208-213 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 192-196 16028369-2 2005 Mitochondrial NADP+ -dependent isocitrate dehydrogenase (IDPm) produces NADPH, an essential reducing equivalent for the antioxidant system. NADP 72-77 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 57-61 16337884-2 2006 Recently, we demonstrated that the control of cytosolic and mitochondrial redox balance and the cellular defense against oxidative damage is one of the primary functions of cytosolic (IDPc) and mitochondrial NADP+ -dependent isocitrate dehydrogenase (IDPm) by supplying NADPH for antioxidant systems. NADP 270-275 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 251-255 17075901-1 2007 The neuroprotective effect of mitochondrial isocitrate dehydrogenase (IDPm), an enzyme involved in the reduction of NADP(+) to NADPH and the supply of glutathione (GSH) in mitochondria, was examined using SH-SY5Y cells overexpressing IDPm (S1). NADP 116-123 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 70-74 17075901-1 2007 The neuroprotective effect of mitochondrial isocitrate dehydrogenase (IDPm), an enzyme involved in the reduction of NADP(+) to NADPH and the supply of glutathione (GSH) in mitochondria, was examined using SH-SY5Y cells overexpressing IDPm (S1). NADP 127-132 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 70-74 17075901-7 2007 These results suggest that the neuroprotective effect of IDPm may result from increases in NADPH and GSH levels in the mitochondria. NADP 91-96 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 57-61 15522197-2 2004 Recently, we demonstrated that the control of mitochondrial redox balance and the cellular defense against oxidative damage is one of the primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) to supply NADPH for antioxidant systems. NADP 233-238 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 217-221