PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27582489-1 2016 NAD+ kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide phosphate (NADP+) using ATP as the phosphate donor. NADP 96-139 NAD kinase Homo sapiens 0-11 27582489-1 2016 NAD+ kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide phosphate (NADP+) using ATP as the phosphate donor. NADP 96-139 NAD kinase Homo sapiens 13-17 27582489-1 2016 NAD+ kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide phosphate (NADP+) using ATP as the phosphate donor. NADP 96-139 NAD kinase Homo sapiens 0-3 27582489-1 2016 NAD+ kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide phosphate (NADP+) using ATP as the phosphate donor. NADP 141-146 NAD kinase Homo sapiens 0-11 27582489-1 2016 NAD+ kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide phosphate (NADP+) using ATP as the phosphate donor. NADP 141-146 NAD kinase Homo sapiens 13-17 27582489-1 2016 NAD+ kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide phosphate (NADP+) using ATP as the phosphate donor. NADP 141-146 NAD kinase Homo sapiens 0-3 26806015-4 2016 This approach reveals oncogenic activity for rare gene aberrations in genes including NAD Kinase (NADK), which regulates NADP(H) homeostasis and cellular redox state. NADP 121-128 NAD kinase Homo sapiens 86-96 26806015-4 2016 This approach reveals oncogenic activity for rare gene aberrations in genes including NAD Kinase (NADK), which regulates NADP(H) homeostasis and cellular redox state. NADP 121-128 NAD kinase Homo sapiens 98-102 16842123-0 2006 Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis. NADP 68-72 NAD kinase Homo sapiens 40-50 25641397-5 2015 The NAD kinase (NADK) is the sole NADP biosynthetic enzyme. NADP 34-38 NAD kinase Homo sapiens 4-14 25641397-5 2015 The NAD kinase (NADK) is the sole NADP biosynthetic enzyme. NADP 34-38 NAD kinase Homo sapiens 16-20 24022322-1 2013 NAD kinase (NADK) is a crucial enzyme for production of NADP+. NADP 56-61 NAD kinase Homo sapiens 0-10 24022322-1 2013 NAD kinase (NADK) is a crucial enzyme for production of NADP+. NADP 56-61 NAD kinase Homo sapiens 12-16 24022322-2 2013 ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes both ATP and poly(P), and is employed in industrial mass production of NADP+. NADP 195-200 NAD kinase Homo sapiens 13-17 24022322-2 2013 ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes both ATP and poly(P), and is employed in industrial mass production of NADP+. NADP 195-200 NAD kinase Homo sapiens 110-114 24022322-5 2013 We also demonstrate that a poly(P)/ATP-NADK created through this method is suitable for the poly(P)-dependent mass production of NADP+. NADP 129-134 NAD kinase Homo sapiens 39-43 22954684-6 2012 Studies of the mechanism by which BR lowers DHFR showed that BR, through its metabolite BAD, reduced NADP and NADPH cellular levels by inhibiting nicotinamide adenine dinucleotide kinase (NADK). NADP 101-105 NAD kinase Homo sapiens 146-186 22954684-6 2012 Studies of the mechanism by which BR lowers DHFR showed that BR, through its metabolite BAD, reduced NADP and NADPH cellular levels by inhibiting nicotinamide adenine dinucleotide kinase (NADK). NADP 101-105 NAD kinase Homo sapiens 188-192 22954684-6 2012 Studies of the mechanism by which BR lowers DHFR showed that BR, through its metabolite BAD, reduced NADP and NADPH cellular levels by inhibiting nicotinamide adenine dinucleotide kinase (NADK). NADP 110-115 NAD kinase Homo sapiens 146-186 22954684-6 2012 Studies of the mechanism by which BR lowers DHFR showed that BR, through its metabolite BAD, reduced NADP and NADPH cellular levels by inhibiting nicotinamide adenine dinucleotide kinase (NADK). NADP 110-115 NAD kinase Homo sapiens 188-192 23212377-1 2012 NAD kinase is the sole NADP(+) biosynthetic enzyme. NADP 23-30 NAD kinase Homo sapiens 0-10 23212377-3 2012 Here we present evidence demonstrating that a human protein of unknown function, C5orf33, is a human mitochondrial NAD kinase; this protein likely represents the missing source of human mitochondrial NADP(+). NADP 200-204 NAD kinase Homo sapiens 115-125 19355893-2 2009 Key reactions for NAD(P) biosynthesis in all organisms, common to both de novo and salvage routes, are catalyzed by NMN/NaMN adenylyltransferase (NMNAT), NAD synthetase (NADS), and NAD kinase (NADK). NADP 18-24 NAD kinase Homo sapiens 181-191 19355893-2 2009 Key reactions for NAD(P) biosynthesis in all organisms, common to both de novo and salvage routes, are catalyzed by NMN/NaMN adenylyltransferase (NMNAT), NAD synthetase (NADS), and NAD kinase (NADK). NADP 18-24 NAD kinase Homo sapiens 193-197 17855339-5 2007 Overexpression of NADK resulted in a 4-5-fold increase in the NADPH, but not NADP(+), concentration, although the recombinant enzyme phosphorylated preferentially NAD(+). NADP 77-84 NAD kinase Homo sapiens 18-22 26219913-1 2015 NAD(+) kinase (NADK) is the only known cytosolic enzyme that converts NAD(+) to NADP(+), which is subsequently reduced to NADPH. NADP 80-87 NAD kinase Homo sapiens 0-13 26219913-1 2015 NAD(+) kinase (NADK) is the only known cytosolic enzyme that converts NAD(+) to NADP(+), which is subsequently reduced to NADPH. NADP 80-87 NAD kinase Homo sapiens 15-19 26219913-1 2015 NAD(+) kinase (NADK) is the only known cytosolic enzyme that converts NAD(+) to NADP(+), which is subsequently reduced to NADPH. NADP 122-127 NAD kinase Homo sapiens 0-13 26219913-1 2015 NAD(+) kinase (NADK) is the only known cytosolic enzyme that converts NAD(+) to NADP(+), which is subsequently reduced to NADPH. NADP 122-127 NAD kinase Homo sapiens 15-19 23616928-13 2013 Identification of MNADK immediately suggests a model in which NADK and MNADK are responsible for de novo synthesis of NADP(+) in cytosol and mitochondria, respectively, and therefore provides novel insights into understanding the sources and mechanisms of mitochondrial NADP(+) and NADH production in human cells. NADP 118-125 NAD kinase Homo sapiens 19-23 23616928-13 2013 Identification of MNADK immediately suggests a model in which NADK and MNADK are responsible for de novo synthesis of NADP(+) in cytosol and mitochondria, respectively, and therefore provides novel insights into understanding the sources and mechanisms of mitochondrial NADP(+) and NADH production in human cells. NADP 270-277 NAD kinase Homo sapiens 19-23 21526340-0 2011 NADPH regulates human NAD kinase, a NADP+-biosynthetic enzyme. NADP 0-5 NAD kinase Homo sapiens 22-32 21526340-0 2011 NADPH regulates human NAD kinase, a NADP+-biosynthetic enzyme. NADP 36-41 NAD kinase Homo sapiens 22-32 21526340-1 2011 NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. NADP 43-50 NAD kinase Homo sapiens 0-10 21526340-1 2011 NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. NADP 43-50 NAD kinase Homo sapiens 12-16 21526340-1 2011 NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. NADP 121-128 NAD kinase Homo sapiens 0-10 21526340-1 2011 NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. NADP 121-128 NAD kinase Homo sapiens 12-16 21526340-5 2011 Using the purified human NADK, we revealed a sigmoidal kinetic behavior toward ATP and the inhibitory effects of NADPH and NADH, but not of NADP(+), on the catalytic activity of the enzyme. NADP 113-118 NAD kinase Homo sapiens 25-29 21526340-5 2011 Using the purified human NADK, we revealed a sigmoidal kinetic behavior toward ATP and the inhibitory effects of NADPH and NADH, but not of NADP(+), on the catalytic activity of the enzyme. NADP 113-117 NAD kinase Homo sapiens 25-29 21526340-7 2011 Furthermore, these attributes may provide a clue to design a novel drug against Mycobacterium tuberculosis in which this bacterial NADK is potently inhibited by NADP(+). NADP 161-168 NAD kinase Homo sapiens 131-135 21730068-1 2011 NAD kinase catalyzes the phosphorylation of NAD(+) to synthesize NADP(+), whereas NADH kinase catalyzes conversion of NADH to NADPH. NADP 65-72 NAD kinase Homo sapiens 0-10 21730068-1 2011 NAD kinase catalyzes the phosphorylation of NAD(+) to synthesize NADP(+), whereas NADH kinase catalyzes conversion of NADH to NADPH. NADP 126-131 NAD kinase Homo sapiens 0-10 19430699-1 2009 NAD kinase catalyzes the phosphorylation of NAD(H) to form NADP(H), using ATP as phosphoryl donor. NADP 59-66 NAD kinase Homo sapiens 0-10 19430699-4 2009 Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of NAD(H)/NADP(H) conversion. NADP 108-115 NAD kinase Homo sapiens 48-58 17083911-4 2006 The product, oxidized nicotinamide adenine dinucleotide phosphate (NADP(+)), formed following the reaction of NADK with NAD(+) and adenosine 5"-triphosphate was detected with the aid of glucose-6-phosphate dehydrogenase or NADP(+)-isocitrate dehydrogenase, iodonitrotetrazolium chloride, and phenazine methosulfate. NADP 22-65 NAD kinase Homo sapiens 110-114 17083911-4 2006 The product, oxidized nicotinamide adenine dinucleotide phosphate (NADP(+)), formed following the reaction of NADK with NAD(+) and adenosine 5"-triphosphate was detected with the aid of glucose-6-phosphate dehydrogenase or NADP(+)-isocitrate dehydrogenase, iodonitrotetrazolium chloride, and phenazine methosulfate. NADP 67-74 NAD kinase Homo sapiens 110-114 17083911-4 2006 The product, oxidized nicotinamide adenine dinucleotide phosphate (NADP(+)), formed following the reaction of NADK with NAD(+) and adenosine 5"-triphosphate was detected with the aid of glucose-6-phosphate dehydrogenase or NADP(+)-isocitrate dehydrogenase, iodonitrotetrazolium chloride, and phenazine methosulfate. NADP 67-71 NAD kinase Homo sapiens 110-114 16242716-0 2005 Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP. NADP 93-97 NAD kinase Homo sapiens 25-35 16242716-1 2005 NAD kinase is a ubiquitous enzyme that catalyzes the phosphorylation of NAD to NADP using ATP or inorganic polyphosphate (poly(P)) as phosphate donor, and is regarded as the only enzyme responsible for the synthesis of NADP. NADP 219-223 NAD kinase Homo sapiens 0-10 16242716-2 2005 We present here the crystal structures of an NAD kinase from the archaeal organism Archaeoglobus fulgidus in complex with its phosphate donor ATP at 1.7 A resolution, with its substrate NAD at 3.05 A resolution, and with the product NADP in two different crystal forms at 2.45 A and 2.0 A resolution, respectively. NADP 233-237 NAD kinase Homo sapiens 45-55 16242716-1 2005 NAD kinase is a ubiquitous enzyme that catalyzes the phosphorylation of NAD to NADP using ATP or inorganic polyphosphate (poly(P)) as phosphate donor, and is regarded as the only enzyme responsible for the synthesis of NADP. NADP 79-83 NAD kinase Homo sapiens 0-10 6309257-3 1983 The electrophoretically homogeneous preparations of NAD-kinase demonstrate a hyperbolic dependence of the NADP synthesis rate on substrate concentration and a loss of dependence of specific activity on the enzyme concentration. NADP 106-110 NAD kinase Homo sapiens 52-62 15855156-1 2005 NAD kinase phosphorylates NAD+ to form NADP+ and is strictly specific to NAD+, whereas NADH kinase phosphorylates both NAD+ and NADH, thereby showing relaxed substrate specificity. NADP 39-44 NAD kinase Homo sapiens 0-10 8135539-4 1994 Final assays testing for the specificity of the phosphoryl donor revealed that not only ATP but also GTP, G6P, and even NADP could be the substrate; the efficiencies of these phosphoryl donors varied with the different isoforms of NAD kinase, evidenced in the different seeds tested, and compared with NAD kinase from heterotropically grown Euglena cells, and NAD kinase purified from chicken liver (from Sigma Chemical Co.). NADP 120-124 NAD kinase Homo sapiens 231-241 8135539-4 1994 Final assays testing for the specificity of the phosphoryl donor revealed that not only ATP but also GTP, G6P, and even NADP could be the substrate; the efficiencies of these phosphoryl donors varied with the different isoforms of NAD kinase, evidenced in the different seeds tested, and compared with NAD kinase from heterotropically grown Euglena cells, and NAD kinase purified from chicken liver (from Sigma Chemical Co.). NADP 120-124 NAD kinase Homo sapiens 302-312 8135539-4 1994 Final assays testing for the specificity of the phosphoryl donor revealed that not only ATP but also GTP, G6P, and even NADP could be the substrate; the efficiencies of these phosphoryl donors varied with the different isoforms of NAD kinase, evidenced in the different seeds tested, and compared with NAD kinase from heterotropically grown Euglena cells, and NAD kinase purified from chicken liver (from Sigma Chemical Co.). NADP 120-124 NAD kinase Homo sapiens 302-312 2154300-4 1990 The calcium increase is responsible for the NADP change (via NAD kinase) and possibly the change in G6PD. NADP 44-48 NAD kinase Homo sapiens 61-71 34133937-4 2021 However, de novo NADP+ is synthesized only through one known enzymatic reaction, catalyzed by NAD+ kinase (NADK). NADP 17-22 NAD kinase Homo sapiens 94-105 34133937-4 2021 However, de novo NADP+ is synthesized only through one known enzymatic reaction, catalyzed by NAD+ kinase (NADK). NADP 17-22 NAD kinase Homo sapiens 107-111 34133937-5 2021 In this study, we show that oncogenic KRAS promotes protein kinase C (PKC)-mediated NADK phosphorylation, leading to its hyperactivation, thus sustaining both NADP+ and NADPH levels in PDAC cells. NADP 159-164 NAD kinase Homo sapiens 84-88 34629356-7 2021 These pioneering findings, i.e., ATP/poly(P)-NAD kinase, NAD kinase gene, and human mitochondrial NAD kinase, have significantly enhanced research on the biochemistry, molecular biology, and evolutionary biology of NAD kinase, mitochondria, and poly(P), including some biotechnological knowledge applicable to NADP+ production. NADP 310-315 NAD kinase Homo sapiens 215-225 34629356-2 2021 Nicotinamide adenine dinucleotide kinase (NAD kinase) catalyzes the phosphorylation of NAD+ to NADP+ in the presence of ATP (ATP-NAD kinase). NADP 95-100 NAD kinase Homo sapiens 0-40 34629356-2 2021 Nicotinamide adenine dinucleotide kinase (NAD kinase) catalyzes the phosphorylation of NAD+ to NADP+ in the presence of ATP (ATP-NAD kinase). NADP 95-100 NAD kinase Homo sapiens 42-52 34629356-3 2021 Novel NAD kinase that explicitly phosphorylates NAD+ to NADP+ using poly(P), besides ATP (ATP/poly(P)-NAD kinase), was found in bacteria, in particular, Gram-positive bacteria, and the gene encoding ATP/poly(P)-NAD kinase was also newly identified in Mycobacterium tuberculosis H37Rv. NADP 56-61 NAD kinase Homo sapiens 6-16 34629356-3 2021 Novel NAD kinase that explicitly phosphorylates NAD+ to NADP+ using poly(P), besides ATP (ATP/poly(P)-NAD kinase), was found in bacteria, in particular, Gram-positive bacteria, and the gene encoding ATP/poly(P)-NAD kinase was also newly identified in Mycobacterium tuberculosis H37Rv. NADP 56-61 NAD kinase Homo sapiens 102-112 34629356-7 2021 These pioneering findings, i.e., ATP/poly(P)-NAD kinase, NAD kinase gene, and human mitochondrial NAD kinase, have significantly enhanced research on the biochemistry, molecular biology, and evolutionary biology of NAD kinase, mitochondria, and poly(P), including some biotechnological knowledge applicable to NADP+ production. NADP 310-315 NAD kinase Homo sapiens 33-55 34629356-7 2021 These pioneering findings, i.e., ATP/poly(P)-NAD kinase, NAD kinase gene, and human mitochondrial NAD kinase, have significantly enhanced research on the biochemistry, molecular biology, and evolutionary biology of NAD kinase, mitochondria, and poly(P), including some biotechnological knowledge applicable to NADP+ production. NADP 310-315 NAD kinase Homo sapiens 57-67 31275331-3 2019 NADK is a key enzyme for NADP (including NADP+ and NADPH) biosynthesis by phosphorylating NAD (including NAD+ and NADH) and therefore, maintains the balance between NAD pool and NADP pool through an allosteric regulation mode. NADP 25-29 NAD kinase Homo sapiens 0-4 33321420-4 2021 We have employed recombinant human NAD kinase expressed in E. coli as an enzymatic reagent to convert readily available synthetic NAD derivatives to NADP analogs, which were subsequently transformed into NAADP derivatives using enzyme catalyzed pyridine base exchange. NADP 149-153 NAD kinase Homo sapiens 35-45 33654713-3 2020 Conventional in vitro NAD kinase assay has been useful to evaluate enzyme activity; however, recent reports revealed a dynamics of NADP pool (the sum of NADP+ and NADPH) under fluctuating light condition, indicating that the rate of NADP synthesis is not always determined by NAD kinase activity. NADP 131-135 NAD kinase Homo sapiens 22-32 33654713-3 2020 Conventional in vitro NAD kinase assay has been useful to evaluate enzyme activity; however, recent reports revealed a dynamics of NADP pool (the sum of NADP+ and NADPH) under fluctuating light condition, indicating that the rate of NADP synthesis is not always determined by NAD kinase activity. NADP 131-135 NAD kinase Homo sapiens 276-286 33654713-4 2020 Here, we developed a novel method for the estimation of chloroplastic NAD kinase activity by quantifying the changes in the NADP amounts in response to illumination. NADP 124-128 NAD kinase Homo sapiens 70-80 239-6 1975 The significance of the kinetics and of the type of inhibition produced by NADPH is discussed in terms of the regulation of NAD kinase activity in vivo. NADP 75-80 NAD kinase Homo sapiens 124-134 33011272-1 2020 NAD kinase (NADK) is required for the de novo synthesis of NADP+ from NAD+. NADP 59-64 NAD kinase Homo sapiens 0-10 33011272-1 2020 NAD kinase (NADK) is required for the de novo synthesis of NADP+ from NAD+. NADP 59-64 NAD kinase Homo sapiens 12-16 31275331-3 2019 NADK is a key enzyme for NADP (including NADP+ and NADPH) biosynthesis by phosphorylating NAD (including NAD+ and NADH) and therefore, maintains the balance between NAD pool and NADP pool through an allosteric regulation mode. NADP 41-46 NAD kinase Homo sapiens 0-4 31275331-3 2019 NADK is a key enzyme for NADP (including NADP+ and NADPH) biosynthesis by phosphorylating NAD (including NAD+ and NADH) and therefore, maintains the balance between NAD pool and NADP pool through an allosteric regulation mode. NADP 51-56 NAD kinase Homo sapiens 0-4 31275331-3 2019 NADK is a key enzyme for NADP (including NADP+ and NADPH) biosynthesis by phosphorylating NAD (including NAD+ and NADH) and therefore, maintains the balance between NAD pool and NADP pool through an allosteric regulation mode. NADP 41-45 NAD kinase Homo sapiens 0-4 31275331-4 2019 In addition, the two respective derivatives from NAD+ (substrate of NADK) and NADP+ (product of NADK), cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), have been considered to be the important messengers for intracellular Ca2+ homeostasis which could finally influence the combination between CaM and NADK, forming a feedback regulation mechanism. NADP 78-83 NAD kinase Homo sapiens 96-100 31275331-4 2019 In addition, the two respective derivatives from NAD+ (substrate of NADK) and NADP+ (product of NADK), cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), have been considered to be the important messengers for intracellular Ca2+ homeostasis which could finally influence the combination between CaM and NADK, forming a feedback regulation mechanism. NADP 78-83 NAD kinase Homo sapiens 96-100 30846598-0 2019 Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. NADP 22-27 NAD kinase Homo sapiens 78-88 30846598-3 2019 Akt phosphorylates NAD kinase (NADK), the sole cytosolic enzyme that catalyzes the synthesis of NADP+ from NAD+ (the oxidized form of NADH), on three serine residues (Ser44, Ser46, and Ser48) within an amino-terminal domain. NADP 96-101 NAD kinase Homo sapiens 19-29 30846598-3 2019 Akt phosphorylates NAD kinase (NADK), the sole cytosolic enzyme that catalyzes the synthesis of NADP+ from NAD+ (the oxidized form of NADH), on three serine residues (Ser44, Ser46, and Ser48) within an amino-terminal domain. NADP 96-101 NAD kinase Homo sapiens 31-35 30846598-4 2019 This phosphorylation stimulates NADK activity both in cells and directly in vitro, thereby increasing NADP+ production. NADP 102-107 NAD kinase Homo sapiens 32-36 30846598-6 2019 These data indicate that Akt-mediated phosphorylation of NADK stimulates its activity to increase NADP+ production through relief of an autoinhibitory function inherent to its amino terminus. NADP 98-103 NAD kinase Homo sapiens 57-61