PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3017222-3	1986	Adenosine-2"-monophospho-5"-diphosphoribose, a competitive inhibitor for the NADPH binding site, blocked the phosphatase-mediated activation of HMG CoA reductase.	NADP	77-82	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	144-161	
31773659-1	2020	The main strategy for lowering blood cholesterol levels is through the inhibition of the NADPH-dependent HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase).	NADP	89-94	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	105-122	
30702149-4	2019	The structures of the apoenzyme and the NADPH complex are highly similar to those of human HMGR.	NADP	40-45	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	91-95	
26758951-4	2017	Statins are inhibitors of HMG-CoA reductase, the enzyme that catalyzes the reduction of HMG-CoA to mevalonic acid by NADPH.	NADP	117-122	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	26-43	
10698924-4	2000	Three crystal structures of the catalytic portion of human HMGR in complexes with HMG-CoA, with HMG and CoA, and with HMG, CoA and NADP(+), provide a detailed view of the enzyme active site.	NADP	131-135	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	59-63	
20418539-3	2010	We propose a rapid and versatile reverse phase-HPLC method for assaying HMGR activity capable of monitoring the levels of both substrates (HMG-CoA and NADPH) and products (CoA, mevalonate, and NADP(+)) in a single 20 min run with no pretreatment required.	NADP	193-200	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	72-76	
19918114-7	2008	CONCLUSIONS: Since NADPH is a necessary cofactor for the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA R), G6PD deficiency appears to be a naturally occurring model of HMG-CoA R restraint, whose consequences are similar to those produced on the same enzyme by statins.	NADP	19-24	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	64-111	
19918114-7	2008	CONCLUSIONS: Since NADPH is a necessary cofactor for the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA R), G6PD deficiency appears to be a naturally occurring model of HMG-CoA R restraint, whose consequences are similar to those produced on the same enzyme by statins.	NADP	19-24	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	113-122	
19918114-7	2008	CONCLUSIONS: Since NADPH is a necessary cofactor for the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA R), G6PD deficiency appears to be a naturally occurring model of HMG-CoA R restraint, whose consequences are similar to those produced on the same enzyme by statins.	NADP	19-24	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	186-195