PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30138624-11 2018 The docking study revealed three separate ligand binding pockets within the hOCT1 translocation pathway, defined by their interactions with three prototypical substrates: MPP+, TEA, and acyclovir. Acyclovir 186-195 solute carrier family 22 member 1 Homo sapiens 76-81 11861798-3 2002 Time- and concentration-dependent uptake of ACV and GCV was observed in hOAT1- and hOCT1-expressing cells. Acyclovir 44-47 solute carrier family 22 member 1 Homo sapiens 83-88 11861798-6 2002 The Km values of ACV uptake by hOAT1 and hOCT1 were 342.3 and 151.2 microM, respectively, whereas those of GCV uptake by hOAT1 and hOCT1 were 895.5 and 516.2 microM, respectively. Acyclovir 17-20 solute carrier family 22 member 1 Homo sapiens 41-46 11861798-9 2002 In conclusion, these results suggest that hOAT1 and hOCT1 mediate renal ACV and GCV transport, whereas hOAT1, hOAT2, hOAT3, and hOAT4 mediate renal AZT transport. Acyclovir 72-75 solute carrier family 22 member 1 Homo sapiens 52-57 34678271-3 2022 In this study, the contribution of physiology (i.e., OCT1 activity) to the oral disposition of acyclovir immediate release (IR) tablets was hypothesized to be greater than dissolution. Acyclovir 95-104 solute carrier family 22 member 1 Homo sapiens 53-57