PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30203438-1 2019 AIMS: To evaluate the role of free fatty acid receptor 2 (FFAR2)/G-protein coupled receptor 43 in mediating the effects of the short chain fatty acids (SCFAs) sodium acetate (SA) and sodium propionate (SP) on islet function in vitro, and to identify the intracellular signalling pathways used in SCFA-induced potentiation of glucose-induced insulin secretion. Sodium Acetate 159-173 free fatty acid receptor 2 Mus musculus 30-56 32482686-10 2020 CONCLUSIONS: Manipulation of the microbiome by a high-fiber diet or supplementation with sodium acetate modified alloimmunity in a kidney transplant model, generating tolerance dependent on Tregs and GPR43. Sodium Acetate 89-103 free fatty acid receptor 2 Mus musculus 200-205 30203438-1 2019 AIMS: To evaluate the role of free fatty acid receptor 2 (FFAR2)/G-protein coupled receptor 43 in mediating the effects of the short chain fatty acids (SCFAs) sodium acetate (SA) and sodium propionate (SP) on islet function in vitro, and to identify the intracellular signalling pathways used in SCFA-induced potentiation of glucose-induced insulin secretion. Sodium Acetate 159-173 free fatty acid receptor 2 Mus musculus 58-63 30203438-1 2019 AIMS: To evaluate the role of free fatty acid receptor 2 (FFAR2)/G-protein coupled receptor 43 in mediating the effects of the short chain fatty acids (SCFAs) sodium acetate (SA) and sodium propionate (SP) on islet function in vitro, and to identify the intracellular signalling pathways used in SCFA-induced potentiation of glucose-induced insulin secretion. Sodium Acetate 159-173 free fatty acid receptor 2 Mus musculus 65-94 30203438-1 2019 AIMS: To evaluate the role of free fatty acid receptor 2 (FFAR2)/G-protein coupled receptor 43 in mediating the effects of the short chain fatty acids (SCFAs) sodium acetate (SA) and sodium propionate (SP) on islet function in vitro, and to identify the intracellular signalling pathways used in SCFA-induced potentiation of glucose-induced insulin secretion. Sodium Acetate 175-177 free fatty acid receptor 2 Mus musculus 30-56 30203438-1 2019 AIMS: To evaluate the role of free fatty acid receptor 2 (FFAR2)/G-protein coupled receptor 43 in mediating the effects of the short chain fatty acids (SCFAs) sodium acetate (SA) and sodium propionate (SP) on islet function in vitro, and to identify the intracellular signalling pathways used in SCFA-induced potentiation of glucose-induced insulin secretion. Sodium Acetate 175-177 free fatty acid receptor 2 Mus musculus 58-63 30203438-1 2019 AIMS: To evaluate the role of free fatty acid receptor 2 (FFAR2)/G-protein coupled receptor 43 in mediating the effects of the short chain fatty acids (SCFAs) sodium acetate (SA) and sodium propionate (SP) on islet function in vitro, and to identify the intracellular signalling pathways used in SCFA-induced potentiation of glucose-induced insulin secretion. Sodium Acetate 175-177 free fatty acid receptor 2 Mus musculus 65-94 30203438-6 2019 SA and SP reversibly potentiated insulin secretion from mouse islets in a FFAR2-dependent manner. Sodium Acetate 0-2 free fatty acid receptor 2 Mus musculus 74-79 30203438-8 2019 SA and SP protected human and mouse islets from apoptosis, and these pro-survival properties were dependent on islet expression of FFAR2. Sodium Acetate 0-2 free fatty acid receptor 2 Mus musculus 131-136 30203438-9 2019 CONCLUSION: Our results indicate that FFAR2 directly mediates both the stimulatory effects of SA and SP on insulin secretion and their protection against islet apoptosis. Sodium Acetate 94-96 free fatty acid receptor 2 Mus musculus 38-43