PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15664409-4 2005 As thiamine metabolism deficiencies have been seen in placental infarcts previously, these indicate that PP20/hTPK may have a role in placental diseases. Thiamine 3-11 thiamin pyrophosphokinase 1 Homo sapiens 105-109 11342117-6 2001 The availability of the human TPK1 gene will provide another useful tool for studying the role of this enzyme in human thiamin metabolism and deficiency state. Thiamine 119-126 thiamin pyrophosphokinase 1 Homo sapiens 30-34 34942318-1 2022 BACKGROUND: Thiamine diphosphate (ThDP), an indispensable cofactor for oxidative energy metabolism, is synthesized through the reaction thiamine + ATP ThDP + AMP, catalyzed by thiamine pyrophosphokinase 1 (TPK1), a cytosolic dimeric enzyme. Thiamine 136-144 thiamin pyrophosphokinase 1 Homo sapiens 178-206 34942318-1 2022 BACKGROUND: Thiamine diphosphate (ThDP), an indispensable cofactor for oxidative energy metabolism, is synthesized through the reaction thiamine + ATP ThDP + AMP, catalyzed by thiamine pyrophosphokinase 1 (TPK1), a cytosolic dimeric enzyme. Thiamine 136-144 thiamin pyrophosphokinase 1 Homo sapiens 208-212 33086386-0 2021 Thiamine Treatment and Favorable Outcome in an Infant with Biallelic TPK1 Variants. Thiamine 0-8 thiamin pyrophosphokinase 1 Homo sapiens 69-73 33231275-0 2021 Thiamine Pyrophosphokinase Deficiency due to Mutations in the TPK1 Gene: A Rare, Treatable Neurodegenerative Disorder. Thiamine 0-8 thiamin pyrophosphokinase 1 Homo sapiens 62-66 33231275-1 2021 TPK deficiency due to TPK1 mutations is a rare neurodegenerative disorder, also known as thiamine metabolism dysfunction syndrome 5 (OMIM no. Thiamine 89-97 thiamin pyrophosphokinase 1 Homo sapiens 22-26 32361878-1 2020 TPK deficiency, also known as thiamine metabolism dysfunction syndrome 5, is a rare autosomal recessive disorder of inborn error of metabolism caused by TPK1 gene mutation. Thiamine 30-38 thiamin pyrophosphokinase 1 Homo sapiens 153-157 30483896-7 2019 Biochemical characterization of reported TPK1 missense mutations suggested reduced thiamine binding as a new disease mechanism. Thiamine 83-91 thiamin pyrophosphokinase 1 Homo sapiens 41-45 31288420-1 2019 TPK1 mutations are a rare, but potentially treatable, cause of thiamine deficiency. Thiamine 63-71 thiamin pyrophosphokinase 1 Homo sapiens 0-4 31095747-2 2019 Currently, four genetic defects have been described causing impairment of thiamine transport and metabolism: SLC19A2 dysfunction leads to diabetes mellitus, megaloblastic anemia and sensory-neural hearing loss, whereas SLC19A3, SLC25A19, and TPK1-related disorders result in recurrent encephalopathy, basal ganglia necrosis, generalized dystonia, severe disability, and early death. Thiamine 74-82 thiamin pyrophosphokinase 1 Homo sapiens 242-246 31095747-8 2019 In SLC25A19 and TPK1 defects, thiamine has also led to clinical stabilization in single cases. Thiamine 30-38 thiamin pyrophosphokinase 1 Homo sapiens 16-20 25788274-3 2015 Thiamine pyrophosphokinase-1 (TPK1), a key component of Vitamin B1/thiamine metabolism, was identified as a target for radiosensitization. Thiamine 56-66 thiamin pyrophosphokinase 1 Homo sapiens 0-28 28747443-0 2017 Thiamine-responsive disease due to mutation of tpk1: Importance of avoiding misdiagnosis. Thiamine 0-8 thiamin pyrophosphokinase 1 Homo sapiens 47-51 30789823-1 2019 Background The mutations of thiamine pyrophosphokinase-1 (TPK1) gene have been frequently studied in some patients with thiamine metabolism dysfunction syndrome-5 (THMD5), while TPK1 mutations in Chinese patients have been investigated by only homozygous. Thiamine 28-36 thiamin pyrophosphokinase 1 Homo sapiens 58-62 30789823-1 2019 Background The mutations of thiamine pyrophosphokinase-1 (TPK1) gene have been frequently studied in some patients with thiamine metabolism dysfunction syndrome-5 (THMD5), while TPK1 mutations in Chinese patients have been investigated by only homozygous. Thiamine 28-36 thiamin pyrophosphokinase 1 Homo sapiens 164-169 30459934-3 2018 Upon uptake, thiamine pyrophosphokinase-1 (TPK1) facilitates the rapid phosphorylation of thiamine into thiamine pyrophosphate (TPP). Thiamine 13-21 thiamin pyrophosphokinase 1 Homo sapiens 43-47 30459934-11 2018 These findings suggest that the adaptive regulation of TPK1 may be an essential component in the cellular response to oxidative stress, and that during supplemental thiamine conditions its expression may be exploited by tumor cells for a redox advantage contributing to tumor progression. Thiamine 165-173 thiamin pyrophosphokinase 1 Homo sapiens 55-59 27191787-2 2016 There are four major genetic defects (SLC19A2, SLC19A3, SLC25A19 and TPK1) involved in the metabolism and transport of thiamine through cellular and mitochondrial membranes. Thiamine 119-127 thiamin pyrophosphokinase 1 Homo sapiens 69-73 27191787-6 2016 Expert commentary: Doses of thiamine vary according to the genetic defect: for SLC19A2, the usual dose is 25-200 mg/day (1-4 mg/kg per day), for SLC19A3, 10-40 mg/kg per day, and for TPK1, 30 mg/kg per day. Thiamine 28-36 thiamin pyrophosphokinase 1 Homo sapiens 183-187 27191787-8 2016 In conclusion, evidence collected so far suggests that the administration of thiamine improves outcome in SLC19A-2, SLC19A3- and TPK1-mutated patients, so most efforts should be aimed at early diagnosis of these disorders. Thiamine 77-85 thiamin pyrophosphokinase 1 Homo sapiens 129-133 25788274-3 2015 Thiamine pyrophosphokinase-1 (TPK1), a key component of Vitamin B1/thiamine metabolism, was identified as a target for radiosensitization. Thiamine 56-66 thiamin pyrophosphokinase 1 Homo sapiens 30-34 25788274-3 2015 Thiamine pyrophosphokinase-1 (TPK1), a key component of Vitamin B1/thiamine metabolism, was identified as a target for radiosensitization. Thiamine 67-75 thiamin pyrophosphokinase 1 Homo sapiens 0-28 25788274-3 2015 Thiamine pyrophosphokinase-1 (TPK1), a key component of Vitamin B1/thiamine metabolism, was identified as a target for radiosensitization. Thiamine 67-75 thiamin pyrophosphokinase 1 Homo sapiens 30-34 23642734-5 2013 Intracellular availability of thiamine is facilitated by the activity of thiamine transporters and thiamine pyrophosphokinase-1 (TPK-1). Thiamine 30-38 thiamin pyrophosphokinase 1 Homo sapiens 99-127 23642734-5 2013 Intracellular availability of thiamine is facilitated by the activity of thiamine transporters and thiamine pyrophosphokinase-1 (TPK-1). Thiamine 30-38 thiamin pyrophosphokinase 1 Homo sapiens 129-134 21612515-4 2011 Thiamine is converted to thiamine diphosphate (TDP) by thiamine diphosphokinase (TDPK). Thiamine 0-8 thiamin pyrophosphokinase 1 Homo sapiens 55-79 21612515-4 2011 Thiamine is converted to thiamine diphosphate (TDP) by thiamine diphosphokinase (TDPK). Thiamine 0-8 thiamin pyrophosphokinase 1 Homo sapiens 81-85 21612515-8 2011 Molecular modeling studies showed that ALT-711 fits into the thiamine-binding pocket of TDPK, and there are three interactions between the thiazolium ring and the enzyme, as well as parallel stacking between the phenyl ring and the indole ring of Trp222B. Thiamine 61-69 thiamin pyrophosphokinase 1 Homo sapiens 88-92