PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22674684-3 2012 Two of the thiamine biosynthesis regulatory genes, THI2 and THI3, were disrupted in the S. cerevisiae parent strain FMME-002. Thiamine 11-19 Thi2p Saccharomyces cerevisiae S288C 51-55 22404710-7 2012 The association of Pdc2p or Thi2p with THI gene promoters was enhanced by thiamin starvation, suggesting that Pdc2p and Thi2p assist each other in their recruitment to the THI promoters via interaction with Thi3p. Thiamine 74-81 Thi2p Saccharomyces cerevisiae S288C 28-33 22404710-7 2012 The association of Pdc2p or Thi2p with THI gene promoters was enhanced by thiamin starvation, suggesting that Pdc2p and Thi2p assist each other in their recruitment to the THI promoters via interaction with Thi3p. Thiamine 74-81 Thi2p Saccharomyces cerevisiae S288C 120-125 22404710-8 2012 It is highly likely that, under thiamin-deprived conditions, a ternary Thi2p/Thi3p/Pdc2p complex is formed and transactivates THI genes in yeast cells. Thiamine 32-39 Thi2p Saccharomyces cerevisiae S288C 71-76 20439498-3 2010 Both of these HDACs associate with a distal region of the affected THI gene promoters that does not overlap with a previously defined enhancer region bound by the thiamine-responsive Thi2/Thi3/Pdc2 transcriptional activators. Thiamine 163-171 Thi2p Saccharomyces cerevisiae S288C 183-187 16850348-9 2006 While the Thi2, in conjunction with Thi3, seems to control expression of THI genes with respect to thiamine availability, the Pdc2 may link the ThDP demand to carbon source availability. Thiamine 99-107 Thi2p Saccharomyces cerevisiae S288C 10-14 1624458-4 1992 These results suggest that thiamine metabolism in S. cerevisiae is subject to two positive regulatory genes, THI2 (PHO6) and THI3. Thiamine 27-35 Thi2p Saccharomyces cerevisiae S288C 109-113 16194233-3 2005 We found in a DNA microarray analysis that the expression of THI genes increased 10- to 90-fold in response to thiamin deprivation, and likewise, the expression of THI2 and THI3 increased 17-fold and threefold, respectively. Thiamine 111-118 Thi2p Saccharomyces cerevisiae S288C 164-168 16194233-9 2005 Furthermore, Thi2p and Thi3p were demonstrated to bind each other and this interaction was partially diminished by exogenous thiamin, suggesting that Thi2p and Thi3p stimulate the expression as a complex whose function is disturbed by TDP bound to Thi3p. Thiamine 125-132 Thi2p Saccharomyces cerevisiae S288C 13-18 16194233-9 2005 Furthermore, Thi2p and Thi3p were demonstrated to bind each other and this interaction was partially diminished by exogenous thiamin, suggesting that Thi2p and Thi3p stimulate the expression as a complex whose function is disturbed by TDP bound to Thi3p. Thiamine 125-132 Thi2p Saccharomyces cerevisiae S288C 150-155 10830262-2 2000 Two of them, PIG1 (= THI1) and PIG4 (= THI2), were found to be highly transcribed in haustoria, and are homologous to genes involved in thiamine (vitamin B1) biosynthesis in yeast. Thiamine 136-144 Thi2p Saccharomyces cerevisiae S288C 39-43 10830262-2 2000 Two of them, PIG1 (= THI1) and PIG4 (= THI2), were found to be highly transcribed in haustoria, and are homologous to genes involved in thiamine (vitamin B1) biosynthesis in yeast. Thiamine 146-156 Thi2p Saccharomyces cerevisiae S288C 39-43 1624458-1 1992 We have isolated a thiamine auxotrophic mutant carrying a recessive mutation which lacks the positive regulatory gene, THI3, which differs in the regulation of thiamine transport from the THI2 (PHO6) gene described previously (Y. Kawasaki, K. Nosaka, Y. Kaneko, H. Nishimura, and A. Iwashima, J. Bacteriol. Thiamine 19-27 Thi2p Saccharomyces cerevisiae S288C 188-192 1624458-1 1992 We have isolated a thiamine auxotrophic mutant carrying a recessive mutation which lacks the positive regulatory gene, THI3, which differs in the regulation of thiamine transport from the THI2 (PHO6) gene described previously (Y. Kawasaki, K. Nosaka, Y. Kaneko, H. Nishimura, and A. Iwashima, J. Bacteriol. Thiamine 19-27 Thi2p Saccharomyces cerevisiae S288C 194-198 1624458-1 1992 We have isolated a thiamine auxotrophic mutant carrying a recessive mutation which lacks the positive regulatory gene, THI3, which differs in the regulation of thiamine transport from the THI2 (PHO6) gene described previously (Y. Kawasaki, K. Nosaka, Y. Kaneko, H. Nishimura, and A. Iwashima, J. Bacteriol. Thiamine 160-168 Thi2p Saccharomyces cerevisiae S288C 188-192 1624458-1 1992 We have isolated a thiamine auxotrophic mutant carrying a recessive mutation which lacks the positive regulatory gene, THI3, which differs in the regulation of thiamine transport from the THI2 (PHO6) gene described previously (Y. Kawasaki, K. Nosaka, Y. Kaneko, H. Nishimura, and A. Iwashima, J. Bacteriol. Thiamine 160-168 Thi2p Saccharomyces cerevisiae S288C 194-198 1624458-4 1992 These results suggest that thiamine metabolism in S. cerevisiae is subject to two positive regulatory genes, THI2 (PHO6) and THI3. Thiamine 27-35 Thi2p Saccharomyces cerevisiae S288C 115-119 1551422-0 1992 Cloning and characteristics of a positive regulatory gene, THI2 (PHO6), of thiamin biosynthesis in Saccharomyces cerevisiae. Thiamine 75-82 Thi2p Saccharomyces cerevisiae S288C 59-63 1551422-1 1992 A thi2(pho6) mutant of Saccharomyces cerevisiae, defective in the expression of structural genes for thiamin-repressible acid phosphatase and enzymes involved in thiamin biosynthesis, was found to retain sufficient thiamin transport activity. Thiamine 162-169 Thi2p Saccharomyces cerevisiae S288C 2-6 1551422-1 1992 A thi2(pho6) mutant of Saccharomyces cerevisiae, defective in the expression of structural genes for thiamin-repressible acid phosphatase and enzymes involved in thiamin biosynthesis, was found to retain sufficient thiamin transport activity. Thiamine 162-169 Thi2p Saccharomyces cerevisiae S288C 7-11 1551422-1 1992 A thi2(pho6) mutant of Saccharomyces cerevisiae, defective in the expression of structural genes for thiamin-repressible acid phosphatase and enzymes involved in thiamin biosynthesis, was found to retain sufficient thiamin transport activity. Thiamine 162-169 Thi2p Saccharomyces cerevisiae S288C 2-6 1551422-1 1992 A thi2(pho6) mutant of Saccharomyces cerevisiae, defective in the expression of structural genes for thiamin-repressible acid phosphatase and enzymes involved in thiamin biosynthesis, was found to retain sufficient thiamin transport activity. Thiamine 162-169 Thi2p Saccharomyces cerevisiae S288C 7-11 1551422-5 1992 Complementation of the enzyme activities for thiamin metabolism in the thi2(pho6) mutant transformed by some plasmids with the TH12(PHO6) gene was also examined. Thiamine 45-52 Thi2p Saccharomyces cerevisiae S288C 71-75 1551422-5 1992 Complementation of the enzyme activities for thiamin metabolism in the thi2(pho6) mutant transformed by some plasmids with the TH12(PHO6) gene was also examined. Thiamine 45-52 Thi2p Saccharomyces cerevisiae S288C 76-80 1551422-5 1992 Complementation of the enzyme activities for thiamin metabolism in the thi2(pho6) mutant transformed by some plasmids with the TH12(PHO6) gene was also examined. Thiamine 45-52 Thi2p Saccharomyces cerevisiae S288C 132-136 1551422-0 1992 Cloning and characteristics of a positive regulatory gene, THI2 (PHO6), of thiamin biosynthesis in Saccharomyces cerevisiae. Thiamine 75-82 Thi2p Saccharomyces cerevisiae S288C 65-69 1551422-1 1992 A thi2(pho6) mutant of Saccharomyces cerevisiae, defective in the expression of structural genes for thiamin-repressible acid phosphatase and enzymes involved in thiamin biosynthesis, was found to retain sufficient thiamin transport activity. Thiamine 101-108 Thi2p Saccharomyces cerevisiae S288C 2-6 1551422-1 1992 A thi2(pho6) mutant of Saccharomyces cerevisiae, defective in the expression of structural genes for thiamin-repressible acid phosphatase and enzymes involved in thiamin biosynthesis, was found to retain sufficient thiamin transport activity. Thiamine 101-108 Thi2p Saccharomyces cerevisiae S288C 7-11 2170344-1 1990 A pho6 mutant of Saccharomyces cerevisiae, lacking a regulatory gene for the synthesis of periplasmic thiamine-repressible acid phosphatase activity, was found to be auxotrophic for thiamine. Thiamine 102-110 Thi2p Saccharomyces cerevisiae S288C 2-6 2170344-1 1990 A pho6 mutant of Saccharomyces cerevisiae, lacking a regulatory gene for the synthesis of periplasmic thiamine-repressible acid phosphatase activity, was found to be auxotrophic for thiamine. Thiamine 182-190 Thi2p Saccharomyces cerevisiae S288C 2-6 2170344-4 1990 These results suggest that thiamine synthesis in S. cerevisiae is subject to a positive regulatory gene, PHO6, whereas it is controlled negatively by the intracellular thiamine level. Thiamine 27-35 Thi2p Saccharomyces cerevisiae S288C 105-109 25494835-4 2014 Thiamine biosynthesis is regulated in response to thiamine availability and is coordinated by the thiamine sensor Thi3p, which activates Pdc2p and Thi2p. Thiamine 0-8 Thi2p Saccharomyces cerevisiae S288C 147-152 25494835-4 2014 Thiamine biosynthesis is regulated in response to thiamine availability and is coordinated by the thiamine sensor Thi3p, which activates Pdc2p and Thi2p. Thiamine 98-106 Thi2p Saccharomyces cerevisiae S288C 147-152