PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17006386-14 2006 Because potential mechanisms exist for thiamine deficiency in diabetes mellitus and institution of insulin and glucose therapy may stress thiamine body stores, thiamine deficiency should be considered in children with diabetic ketoacidosis whose encephalopathy does not improve with improvement of biochemical status. Thiamine 138-146 insulin Homo sapiens 99-106 17006386-14 2006 Because potential mechanisms exist for thiamine deficiency in diabetes mellitus and institution of insulin and glucose therapy may stress thiamine body stores, thiamine deficiency should be considered in children with diabetic ketoacidosis whose encephalopathy does not improve with improvement of biochemical status. Thiamine 138-146 insulin Homo sapiens 99-106 16373304-9 2006 CONCLUSION: Diabetes in this syndrome is due to an insulin insufficiency that initially responds to thiamine supplements; however, most patients become fully insulin dependent after puberty. Thiamine 100-108 insulin Homo sapiens 51-58 2537896-3 1989 A month after institution of treatment with thiamine, the hematologic findings had returned to normal and the insulin requirements had decreased. Thiamine 44-52 insulin Homo sapiens 110-117 14994241-11 2004 With oral thiamine therapy, her insulin requirement decreased by 30% over a 20 month period. Thiamine 10-18 insulin Homo sapiens 32-39 11021334-4 2000 Thiamine is essential for glucose oxidation, insulin production by pancreatic beta-cells and cell growth. Thiamine 0-8 insulin Homo sapiens 45-52 10629262-0 2000 Thiamine (Vitamin B1) protects against glucose- and insulin-mediated proliferation of human infragenicular arterial smooth muscle cells. Thiamine 0-8 insulin Homo sapiens 52-59 10629262-0 2000 Thiamine (Vitamin B1) protects against glucose- and insulin-mediated proliferation of human infragenicular arterial smooth muscle cells. Thiamine 10-20 insulin Homo sapiens 52-59 10629262-4 2000 The objective of this study is to determine the effect of thiamine on human infragenicular ASMC proliferation induced by high glucose and insulin levels in vitro. Thiamine 58-66 insulin Homo sapiens 138-145 10629262-10 2000 The data suggest that thiamine inhibits human infragenicular ASMC proliferation induced by high glucose and insulin. Thiamine 22-30 insulin Homo sapiens 108-115 11214358-4 2000 Indeed, cord blood from neonates born to mothers treated with insulin for GDM had significantly higher thiamin concentration than other neonates in the study. Thiamine 103-110 insulin Homo sapiens 62-69 8394635-5 1993 After thiamine therapy was ceased an increase in insulin requirement was observed and macrocytic anemia developed again. Thiamine 6-14 insulin Homo sapiens 49-56 2537896-4 1989 Withdrawal of thiamine repeatedly induced relapse of the anemia and an increase in insulin requirements. Thiamine 14-22 insulin Homo sapiens 83-90 3523986-5 1986 Insulin and cocarboxylase as well as insulin combined with thiamin and adenine exhibited the best effect on the patterns studied; these drugs normalized the vitamin B1 metabolism and improved the parameters of energy metabolism within 120 min of incubation in erythrocytes isolated from blood of patients with diabetes mellitus. Thiamine 157-167 insulin Homo sapiens 0-7 3523986-5 1986 Insulin and cocarboxylase as well as insulin combined with thiamin and adenine exhibited the best effect on the patterns studied; these drugs normalized the vitamin B1 metabolism and improved the parameters of energy metabolism within 120 min of incubation in erythrocytes isolated from blood of patients with diabetes mellitus. Thiamine 157-167 insulin Homo sapiens 37-44 29379566-5 2018 After treatment of thiamine, diabetes was controlled and insulin was discontinued. Thiamine 19-27 insulin Homo sapiens 57-64 5469044-2 1970 The influence of glucose and insulin on intestinal resorption of thiamine-S 35]. Thiamine 65-75 insulin Homo sapiens 29-36 14391377-0 1955 [Action of insulin on the phosphorylation of thiamine in vitro]. Thiamine 45-53 insulin Homo sapiens 11-18 14910767-0 1952 Action of insulin on thiamine phosphorylation. Thiamine 21-29 insulin Homo sapiens 10-17 30311825-10 2018 Daily supplementation with an individualized ALA, carnosine, and thiamine supplement effectively reduced glucose concentration in type 2 diabetic patients, probably by increasing insulin production from the pancreas. Thiamine 65-73 insulin Homo sapiens 179-186 13244665-0 1955 Action of insulin on thiamine phosphorylation in vitro. Thiamine 21-29 insulin Homo sapiens 10-17 28371426-0 2018 Recovered insulin production after thiamine administration in permanent neonatal diabetes mellitus with a novel solute carrier family 19 member 2 (SLC19A2) mutation. Thiamine 35-43 insulin Homo sapiens 10-17 28371426-8 2018 After oral thiamine administration, the patient"s fasting C-peptide levels increased gradually, and there was a marked decrease in insulin requirements. Thiamine 11-19 insulin Homo sapiens 131-138 25560422-12 2015 After 8 hours of insulin therapy, seven of 20 patients (35%) had thiamine deficiency, and four of these seven patients also had thiamine deficiency at presentation. Thiamine 65-73 insulin Homo sapiens 17-24 27440134-0 2017 Thiamine Levels During Intensive Insulin Therapy in Critically Ill Patients. Thiamine 0-8 insulin Homo sapiens 33-40 27440134-3 2017 In this study, we investigated the prevalence of thiamine deficiency at admission to the intensive care unit (ICU) and hypothesized that intensive insulin therapy, aimed at regulating glucose levels, increases thiamine utilization and therefore might cause or worsen deficiency in patients with limited thiamine stores. Thiamine 49-57 insulin Homo sapiens 147-154 27440134-3 2017 In this study, we investigated the prevalence of thiamine deficiency at admission to the intensive care unit (ICU) and hypothesized that intensive insulin therapy, aimed at regulating glucose levels, increases thiamine utilization and therefore might cause or worsen deficiency in patients with limited thiamine stores. Thiamine 210-218 insulin Homo sapiens 147-154 27440134-3 2017 In this study, we investigated the prevalence of thiamine deficiency at admission to the intensive care unit (ICU) and hypothesized that intensive insulin therapy, aimed at regulating glucose levels, increases thiamine utilization and therefore might cause or worsen deficiency in patients with limited thiamine stores. Thiamine 210-218 insulin Homo sapiens 147-154 25816395-3 2015 Thiamine administration was also reported to prevent deterioration in fasting glucose and insulin levels, and to improve glucose tolerance in hyperglycemic patients. Thiamine 0-8 insulin Homo sapiens 90-97 25560422-12 2015 After 8 hours of insulin therapy, seven of 20 patients (35%) had thiamine deficiency, and four of these seven patients also had thiamine deficiency at presentation. Thiamine 128-136 insulin Homo sapiens 17-24 25560422-13 2015 Sixty-eight percent of patients had a decrease in thiamine levels after 8 hours of insulin therapy, with a mean fall of 20 +- 31.4 nmol/L. Thiamine 50-58 insulin Homo sapiens 83-90 23715873-9 2013 CONCLUSION/INTERPRETATION: Supplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia. Thiamine 58-66 insulin Homo sapiens 116-123