PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23341335-4	2013	Our results show that thiamin biosynthesis is largely regulated by the circadian clock via the activity of the THIAMIN C SYNTHASE (THIC) promoter, while the riboswitch located at the 3" untranslated region of this gene controls overall thiamin biosynthesis.	Thiamine	22-29	thiaminC	Arabidopsis thaliana	111-129	
31911438-8	2020	Using bimolecular fluorescence complementation and in vitro Fe-S cluster transfer experiments, we confirmed interactions with two proteins involved in isoprenoid and thiamine biosynthesis, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ISPG) and 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase (THIC), respectively.	Thiamine	166-174	thiaminC	Arabidopsis thaliana	319-323	
26454882-11	2015	Resulting THI1 x THIC plants accumulated up to 3.4- and 2.6-fold more total thiamin than wild-type plants in leaf and seeds, respectively.	Thiamine	76-83	thiaminC	Arabidopsis thaliana	17-21	
23341335-4	2013	Our results show that thiamin biosynthesis is largely regulated by the circadian clock via the activity of the THIAMIN C SYNTHASE (THIC) promoter, while the riboswitch located at the 3" untranslated region of this gene controls overall thiamin biosynthesis.	Thiamine	22-29	thiaminC	Arabidopsis thaliana	131-135	
23341335-6	2013	Our model suggests that in Arabidopsis, the THIC promoter and the thiamin-pyrophosphate riboswitch act simultaneously to tightly regulate thiamin biosynthesis in a circadian manner and consequently sense and control vital points of core cellular metabolism.	Thiamine	66-73	thiaminC	Arabidopsis thaliana	44-48	
18533652-2	2008	In plants, TPP regulates its own production by binding to the 3" untranslated region of the mRNA encoding ThiC, a critical enzyme in thiamine biosynthesis, which promotes the formation of an unstable splicing variant.	Thiamine	133-141	thiaminC	Arabidopsis thaliana	106-110	
19812694-11	2009	Two classical genetic markers (PY, ALB1) were identified based on similar map locations of known genes required for thiamine (THIC) and chlorophyll (PDE166) biosynthesis.	Thiamine	116-124	thiaminC	Arabidopsis thaliana	126-130	
18332905-0	2008	AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana.	Thiamine	27-35	thiaminC	Arabidopsis thaliana	0-6	
18332905-4	2008	Here we report the molecular characterization of AtTHIC, which is involved in thiamine biosynthesis in Arabidopsis.	Thiamine	78-86	thiaminC	Arabidopsis thaliana	49-55	
18332905-7	2008	Downregulation of AtTHIC expression by T-DNA insertion at its promoter region resulted in a drastic reduction of thiamine content in plants and the knock-down mutant thic1 showed albino (white leaves) and lethal phenotypes under the normal culture conditions.	Thiamine	113-121	thiaminC	Arabidopsis thaliana	18-24	
18332905-10	2008	AtTHIC was strongly expressed in leaves, flowers and siliques and the transcription of AtTHIC was downregulated by extrinsic thiamine.	Thiamine	125-133	thiaminC	Arabidopsis thaliana	0-6	
18332905-10	2008	AtTHIC was strongly expressed in leaves, flowers and siliques and the transcription of AtTHIC was downregulated by extrinsic thiamine.	Thiamine	125-133	thiaminC	Arabidopsis thaliana	87-93	
18332905-11	2008	In conclusion, AtTHIC is a gene involved in pyrimidine synthesis in the thiamine biosynthesis pathway of Arabidopsis, and our results provide some new clues for elucidating the pathway of thiamine biosynthesis in plants.	Thiamine	72-80	thiaminC	Arabidopsis thaliana	15-21	
18332905-11	2008	In conclusion, AtTHIC is a gene involved in pyrimidine synthesis in the thiamine biosynthesis pathway of Arabidopsis, and our results provide some new clues for elucidating the pathway of thiamine biosynthesis in plants.	Thiamine	188-196	thiaminC	Arabidopsis thaliana	15-21	
18048325-6	2007	Here, we identify a homolog of THIC in Arabidopsis and demonstrate its essentiality not only for vitamin B1 biosynthesis, but also plant viability.	Thiamine	97-107	thiaminC	Arabidopsis thaliana	31-35	
18048325-0	2007	Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC.	Thiamine	0-10	thiaminC	Arabidopsis thaliana	86-90	
18048325-9	2007	The results suggest that vitamin B1 biosynthesis in plants is in fact more similar to prokaryotic counterparts and that the THIC protein is likely to be the key regulatory protein in the pathway.	Thiamine	25-35	thiaminC	Arabidopsis thaliana	124-128