PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33037045-3 2020 Similarly, the effects of OCT1 deficiency on the pharmacokinetics of thiamine were reported to differ between human and mouse. Thiamine 69-77 solute carrier family 22 member 1 Homo sapiens 26-30 33967805-1 2021 Organic Cation Transporter 1 (OCT1, gene symbol: SLC22A1) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and facilitates the uptake of endogenous compounds (e.g. serotonin, acetylcholine, thiamine), and widely prescribed drugs (e.g. metformin, fenoterol, morphine). Thiamine 237-245 solute carrier family 22 member 1 Homo sapiens 0-28 33967805-1 2021 Organic Cation Transporter 1 (OCT1, gene symbol: SLC22A1) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and facilitates the uptake of endogenous compounds (e.g. serotonin, acetylcholine, thiamine), and widely prescribed drugs (e.g. metformin, fenoterol, morphine). Thiamine 237-245 solute carrier family 22 member 1 Homo sapiens 30-34 33967805-1 2021 Organic Cation Transporter 1 (OCT1, gene symbol: SLC22A1) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and facilitates the uptake of endogenous compounds (e.g. serotonin, acetylcholine, thiamine), and widely prescribed drugs (e.g. metformin, fenoterol, morphine). Thiamine 237-245 solute carrier family 22 member 1 Homo sapiens 49-56 33037045-10 2020 In conclusion, the contribution of human OCT1 to the cellular uptake of thiamine and especially of metformin may be much lower than that of mouse OCT1. Thiamine 72-80 solute carrier family 22 member 1 Homo sapiens 41-45 33037045-13 2020 Significance Statement OCT1 is a major hepatic uptake transporter of metformin and thiamine, but we report strong differences in the affinity for both compounds between human and mouse OCT1. Thiamine 83-91 solute carrier family 22 member 1 Homo sapiens 23-27 26157489-1 2015 BACKGROUND: The organic cation transporter OCT1 (SLC22A1) mediates the uptake of vitamin B1, cationic drugs, and xenobiotics into hepatocytes. Thiamine 81-91 solute carrier family 22 member 1 Homo sapiens 43-47 31593619-0 2020 Variability and heritability of thiamine pharmacokinetics with focus on OCT1 effects on membrane transport and pharmacokinetics in humans. Thiamine 32-40 solute carrier family 22 member 1 Homo sapiens 72-76 31593619-1 2020 Thiamine is substrate of the hepatic uptake transporter OCT1, and pathological lipid metabolism was associated with OCT1-dependent thiamine transport. Thiamine 0-8 solute carrier family 22 member 1 Homo sapiens 56-60 31593619-1 2020 Thiamine is substrate of the hepatic uptake transporter OCT1, and pathological lipid metabolism was associated with OCT1-dependent thiamine transport. Thiamine 131-139 solute carrier family 22 member 1 Homo sapiens 56-60 31593619-1 2020 Thiamine is substrate of the hepatic uptake transporter OCT1, and pathological lipid metabolism was associated with OCT1-dependent thiamine transport. Thiamine 131-139 solute carrier family 22 member 1 Homo sapiens 116-120 31593619-4 2020 The variant OCT1*2 had reduced and OCT1*3 to OCT1*6 had deficient thiamine uptake activity. Thiamine 66-74 solute carrier family 22 member 1 Homo sapiens 12-16 31593619-4 2020 The variant OCT1*2 had reduced and OCT1*3 to OCT1*6 had deficient thiamine uptake activity. Thiamine 66-74 solute carrier family 22 member 1 Homo sapiens 35-39 31593619-4 2020 The variant OCT1*2 had reduced and OCT1*3 to OCT1*6 had deficient thiamine uptake activity. Thiamine 66-74 solute carrier family 22 member 1 Homo sapiens 35-39 30544975-1 2018 The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine. Thiamine 239-247 solute carrier family 22 member 1 Homo sapiens 4-32 30544975-1 2018 The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine. Thiamine 239-247 solute carrier family 22 member 1 Homo sapiens 34-38 30544975-1 2018 The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine. Thiamine 239-247 solute carrier family 22 member 1 Homo sapiens 40-47 30138624-2 2018 The substrates and inhibitors of hOCT1 are structurally and physiochemically diverse and include some widely prescribed drugs (metformin and imatinib), vitamins (thiamine), and neurotransmitters (serotonin). Thiamine 162-170 solute carrier family 22 member 1 Homo sapiens 33-38 26528626-3 2015 Recently, our laboratory demonstrated that organic cation transporter 1, OCT1, the major hepatic uptake transporter for metformin, was also the primary hepatic uptake transporter for thiamine, vitamin B1. Thiamine 183-191 solute carrier family 22 member 1 Homo sapiens 43-71 26528626-3 2015 Recently, our laboratory demonstrated that organic cation transporter 1, OCT1, the major hepatic uptake transporter for metformin, was also the primary hepatic uptake transporter for thiamine, vitamin B1. Thiamine 183-191 solute carrier family 22 member 1 Homo sapiens 73-77 31593619-6 2020 Further studies in primary human hepatocytes indicated that several cation transporters including OCT1, OCT3, and THTR-2 contribute to hepatic uptake of thiamine. Thiamine 153-161 solute carrier family 22 member 1 Homo sapiens 98-102 26528626-3 2015 Recently, our laboratory demonstrated that organic cation transporter 1, OCT1, the major hepatic uptake transporter for metformin, was also the primary hepatic uptake transporter for thiamine, vitamin B1. Thiamine 193-203 solute carrier family 22 member 1 Homo sapiens 43-71 26528626-3 2015 Recently, our laboratory demonstrated that organic cation transporter 1, OCT1, the major hepatic uptake transporter for metformin, was also the primary hepatic uptake transporter for thiamine, vitamin B1. Thiamine 193-203 solute carrier family 22 member 1 Homo sapiens 73-77 26157489-1 2015 BACKGROUND: The organic cation transporter OCT1 (SLC22A1) mediates the uptake of vitamin B1, cationic drugs, and xenobiotics into hepatocytes. Thiamine 81-91 solute carrier family 22 member 1 Homo sapiens 49-56 22387857-4 2012 In conclusion, our results are compatible with the possibility of thiamine being transported not only by ThTr1 and/or ThTr2, but also by members of the OCT family of transporters (most probably OCT1 and/or OCT3), thus sharing the same transporters with several other organic cations at the small intestinal level. Thiamine 66-74 solute carrier family 22 member 1 Homo sapiens 194-198