PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34390792-2	2021	The aim of this study is to understand how alimentary TD, accompanied by OS, affects the expression and level of two thiamine metabolism proteins in rat brain, namely, thiamine transporter 1 (THTR1) and thiamine pyrophosphokinase (TPK1), and what factors are responsible for the observed changes.	Thiamine	117-125	thiamin pyrophosphokinase 1	Rattus norvegicus	231-235	
34390792-9	2021	A single high-dose thiamine administration to TD animals had no effect on THTR1 expression, partly raised TPK1 mRNA and protein levels, but is unable to normalize TPK1 enzyme activity.	Thiamine	19-27	thiamin pyrophosphokinase 1	Rattus norvegicus	106-110	
6093881-7	1984	A kinetic study of thiamine uptake by rat hepatocytes preloaded with pyrithiamine, a potent inhibitor of thiamine pyrophosphokinase, revealed that the biphasic property of thiamine uptake disappeared and a single carrier system for thiamine with a Kt of 40.5 microM, which was similar to the Kt value of the low affinity process, was retained.	Thiamine	73-81	thiamin pyrophosphokinase 1	Rattus norvegicus	105-131	
6093881-7	1984	A kinetic study of thiamine uptake by rat hepatocytes preloaded with pyrithiamine, a potent inhibitor of thiamine pyrophosphokinase, revealed that the biphasic property of thiamine uptake disappeared and a single carrier system for thiamine with a Kt of 40.5 microM, which was similar to the Kt value of the low affinity process, was retained.	Thiamine	73-81	thiamin pyrophosphokinase 1	Rattus norvegicus	105-131	
6093881-8	1984	These results strongly suggest that thiamine transport system in rat liver cells is closely connected with thiamine pyrophosphokinase, which accelerates the uptake rat of thiamine by pyrophosphorylation at physiological concentrations of thiamine.	Thiamine	36-44	thiamin pyrophosphokinase 1	Rattus norvegicus	107-133	
94830-0	1979	Thiamine intestinal transport and phosphorylation : a study in vitro of potential inhibitors of small intestinal thiamine-pyrophosphokinase using a crude enzymatic preparation.	Thiamine	0-8	thiamin pyrophosphokinase 1	Rattus norvegicus	113-139	
94830-3	1979	Eleven thiamine structural analogs and derivatives were assayed for their inhibitory action on the small intestine thiamine-pyrophosphokinase activity.	Thiamine	7-15	thiamin pyrophosphokinase 1	Rattus norvegicus	115-141	
6093881-7	1984	A kinetic study of thiamine uptake by rat hepatocytes preloaded with pyrithiamine, a potent inhibitor of thiamine pyrophosphokinase, revealed that the biphasic property of thiamine uptake disappeared and a single carrier system for thiamine with a Kt of 40.5 microM, which was similar to the Kt value of the low affinity process, was retained.	Thiamine	19-27	thiamin pyrophosphokinase 1	Rattus norvegicus	105-131	
201581-0	1977	Thiamine pyrophosphokinase activity in liver, heart and brain crude extracts of control and thiamine deficient rats.	Thiamine	92-100	thiamin pyrophosphokinase 1	Rattus norvegicus	0-26