PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33562625-1 2021 We present an integrated delivery technology herein employing the aerosolized method to repurpose thioflavin S for imaging amyloid beta (Abeta) deposits in the retina as a surrogate of Abeta in the brain for early detection of Alzheimer"s disease. thioflavin T 98-110 amyloid beta (A4) precursor protein Mus musculus 137-142 33562625-4 2021 Furthermore, the fluorescent signal depicted from thioflavin S corroborates with Abeta immunohistochemistry staining information. thioflavin T 50-62 amyloid beta (A4) precursor protein Mus musculus 81-86 32619650-6 2020 Thioflavin S staining was used to observe Abeta deposition. thioflavin T 0-12 amyloid beta (A4) precursor protein Mus musculus 42-47 33452414-2 2021 In transgenic models selectively expressing amyloid-beta (Abeta), thioflavin S (ThS), a fluorescent dye with beta-sheet binding properties, is widely employed to observe amyloid plaque accumulation. thioflavin T 66-78 amyloid beta (A4) precursor protein Mus musculus 58-63 33452414-2 2021 In transgenic models selectively expressing amyloid-beta (Abeta), thioflavin S (ThS), a fluorescent dye with beta-sheet binding properties, is widely employed to observe amyloid plaque accumulation. thioflavin T 80-83 amyloid beta (A4) precursor protein Mus musculus 58-63 33452414-3 2021 In this study, we investigated the possibility that a commonly used Abeta-expressing AD model mouse, 5XFAD, generates ThS-positive aggregates of beta-sheet structures in addition to Abeta fibrils. thioflavin T 118-121 amyloid beta (A4) precursor protein Mus musculus 68-73 33452414-6 2021 Upon administration of a small molecule that exclusively disaggregates Abeta to 5XFAD mice for six weeks, we found that the reduction level of plaques was smaller in brain sections stained by ThS compared to an anti-Abeta antibody. thioflavin T 192-195 amyloid beta (A4) precursor protein Mus musculus 71-76 33452414-7 2021 Our findings implicate that the use of ThS complicates the quantification of amyloid plaques and the assessment of Abeta-targeting drugs in 5XFAD mice. thioflavin T 39-42 amyloid beta (A4) precursor protein Mus musculus 115-120 33681712-9 2021 These anti-cytotoxic effects can be derived from the inhibitory functions of borrelidins against the Abeta aggregation as shown in thioflavin T and gel electrophoretic analyses. thioflavin T 131-143 amyloid beta (A4) precursor protein Mus musculus 101-106 32471773-6 2021 RESULTS: Compound 1 displays characteristics of Abeta binding dyes, such as thioflavin-S, in that it labels both parenchymal Abeta plaques and CAA when applied to histological sections from both a transgenic APP/PS1 mouse model of Abeta amyloidosis and AD brain. thioflavin T 76-88 amyloid beta (A4) precursor protein Mus musculus 48-53 30097010-7 2018 CONCLUSIONS: The fluorescence of functionalized NDs is more stable than that of fluorescent markers commonly used to stain Abeta aggregates such as Thioflavin T. thioflavin T 148-160 amyloid beta (A4) precursor protein Mus musculus 123-128 32410038-3 2020 In this chapter, we describe two techniques for the histological detection of Abeta, immunostaining with Abeta antibodies and staining with the amyloid dye thioflavin S, and its quantification using digital imaging. thioflavin T 156-168 amyloid beta (A4) precursor protein Mus musculus 78-83 30584141-6 2019 Our results showed that when pretreated with 3.0 mg/kg LPS, thioflavin S can be found in the brain bound to Abeta plaques in aged 5XFAD transgenic mice. thioflavin T 60-72 amyloid beta (A4) precursor protein Mus musculus 108-113 30584141-9 2019 Our results suggest that the BBB in aged 5XFAD mouse model is susceptible to increased permeability mediated by LPS, allowing for improved delivery of the small molecule thioflavin S to target Abeta plaques and SPIO nanoparticles, which are significantly larger than antibodies used in clinical trials for immunotherapy of AD. thioflavin T 170-182 amyloid beta (A4) precursor protein Mus musculus 193-198 32786307-5 2020 In addition, AMF binds to Abeta fibrils with a high affinity (Ki = 287 +- 20 nM) - as revealed by a competition thioflavin T (ThT) assay, and specifically labels the amyloid plaques ex vivo in the brain sections of transgenic AD mice - as confirmed via immunostaining with an Abeta antibody. thioflavin T 112-124 amyloid beta (A4) precursor protein Mus musculus 26-31 32786307-5 2020 In addition, AMF binds to Abeta fibrils with a high affinity (Ki = 287 +- 20 nM) - as revealed by a competition thioflavin T (ThT) assay, and specifically labels the amyloid plaques ex vivo in the brain sections of transgenic AD mice - as confirmed via immunostaining with an Abeta antibody. thioflavin T 126-129 amyloid beta (A4) precursor protein Mus musculus 26-31 26923013-6 2016 Yet, combined therapy enhanced thioflavin-S labeled Abeta plaque burden, a tendency not significant when Abeta1 - 42 plaque load was considered. thioflavin T 31-43 amyloid beta (A4) precursor protein Mus musculus 52-57 29311134-5 2018 Ablation of Klk7 exacerbated the thioflavin S-positive Abeta pathology in AD model mice. thioflavin T 33-43 amyloid beta (A4) precursor protein Mus musculus 55-60 23614719-7 2013 Thioflavin T measurements and immunoblotting indicated different structural properties for the different Abeta oligomers. thioflavin T 0-12 amyloid beta (A4) precursor protein Mus musculus 105-110 25278441-8 2014 Thioflavin T staining indicated that homogeneous Abeta was achieved. thioflavin T 0-12 amyloid beta (A4) precursor protein Mus musculus 49-54 24717291-3 2014 Fluorescent imaging demonstrated that 2 and 8 clearly stained thioflavin-S positive Abeta plaques in the brain sections of Tg2576 transgenic mice. thioflavin T 62-74 amyloid beta (A4) precursor protein Mus musculus 84-89 20806406-4 2010 The results of this study provide direct evidence showing association among Abeta pathology (intracellular deposition of thioflavine S-positive materials), neuronal degeneration, and metabolic changes observable with in vivo (1)H-MRS in the hippocampus of APP(Swe)/PS1(dE9) mice. thioflavin T 121-132 amyloid beta (A4) precursor protein Mus musculus 76-81 23509974-5 2013 Staining of Abeta plaques was confirmed via staining of the same sections with the fluorescent amyloid binding dye Thioflavin S. thioflavin T 115-127 amyloid beta (A4) precursor protein Mus musculus 12-17 18955112-4 2008 However, a thioflavin derivative, Pittsburgh Compound-B (PIB), which is a successful PET tracer for detecting Abeta plaques in AD brains, does not visualize Abeta plaques in APP and PS1/APP transgenic mice. thioflavin T 11-21 amyloid beta (A4) precursor protein Mus musculus 110-115 12603271-7 2003 Synthetic Abeta was used to produce three different samples (Abeta-fibrilar; Abeta-aggregated; Abeta-AGE), which were characterized for beta-sheeted fibrils by the thioflavin-T test and electron microscopy. thioflavin T 164-176 amyloid beta (A4) precursor protein Mus musculus 10-15 16386399-2 2006 Here, we prepared nanoparticles as carriers for the model drugs thioflavin T and thioflavin S that bind fibrillar amyloid beta peptides (Abeta). thioflavin T 64-76 amyloid beta (A4) precursor protein Mus musculus 137-142 16386399-2 2006 Here, we prepared nanoparticles as carriers for the model drugs thioflavin T and thioflavin S that bind fibrillar amyloid beta peptides (Abeta). thioflavin T 81-93 amyloid beta (A4) precursor protein Mus musculus 137-142 16386399-7 2006 In the cortices of 7-14 months old APP/PS1 mice with age-dependent beta-amyloidosis, thioflavins selectively targeted fibrillar Abeta after biodegradation-induced release from their nanoparticulate carriers upon intracerebral injection. thioflavin T 85-96 amyloid beta (A4) precursor protein Mus musculus 128-133 12697936-3 2003 A beta deposits were detected by immunostaining and thioflavin fluorescence, and quantified by using high-throughput digital image acquisition and analysis. thioflavin T 52-62 amyloid beta (A4) precursor protein Mus musculus 0-6 15505373-3 2004 In contrast, filamentous, thioflavine S-positive amyloid deposition in AbetaPP/PS mice was catalyzed at least 3000 fold by apoE. thioflavin T 26-37 amyloid beta (A4) precursor protein Mus musculus 71-78 14985348-8 2004 The vascular Abeta accumulations were fibrillar, exhibiting strong thioflavin S staining, and occasionally presented signs of microhemorrhage. thioflavin T 67-79 amyloid beta (A4) precursor protein Mus musculus 13-18 11045665-3 2000 Elimination of APOE resulted in a redistribution and alteration in the character of Abeta deposition in homozygous APP(V717F) tg mice, with a dramatic reduction in cortical and dentate gyrus deposition, prominent increase in diffuse CA1 and CA3 deposition, and prevention of the formation of thioflavin-S-positive deposits. thioflavin T 292-304 amyloid beta (A4) precursor protein Mus musculus 84-89 34592066-4 2022 Immunostaining with two types of specific antibodies for Abeta identified the clear presence of Abeta peptides associated with: (1) carcinoma cells and (2) extracellular aggregated amyloid (also revealed by Congo red and thioflavin S staining). thioflavin T 221-233 amyloid beta (A4) precursor protein Mus musculus 96-101 1438289-7 1992 Thioflavin S histochemistry suggested accumulations of amyloid in the cerebrovasculature of transgenic mice with the highest expression of the beta APP-C100 transgene. thioflavin T 0-12 amyloid beta (A4) precursor protein Mus musculus 143-151 34986530-5 2021 The beta-amyloid protein (Abeta) depositions in cortex and hippocampal CA1 area of mice were detected by thioflavin T staining. thioflavin T 105-117 amyloid beta (A4) precursor protein Mus musculus 26-31 34232542-5 2021 The effect of IMRCs on amyloid-beta (Abeta)-related pathology was detected by thioflavin-S staining and Western blot. thioflavin T 78-90 amyloid beta (A4) precursor protein Mus musculus 37-42