PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23911439-10	2013	Interestingly, tetracaine and carvedilol used to reduce ryanodine receptor (RyR) diastolic Ca(2+) release, and ruthenium red used to prevent Ca(2+) entry into the mitochondria prevented RP-induced cell death, whereas PI3K inhibition with Wortmannin exacerbated pacing-induced cell mortality.	Tetracaine	15-25	ryanodine receptor 2	Rattus norvegicus	56-74	
23911439-10	2013	Interestingly, tetracaine and carvedilol used to reduce ryanodine receptor (RyR) diastolic Ca(2+) release, and ruthenium red used to prevent Ca(2+) entry into the mitochondria prevented RP-induced cell death, whereas PI3K inhibition with Wortmannin exacerbated pacing-induced cell mortality.	Tetracaine	15-25	ryanodine receptor 2	Rattus norvegicus	76-79	
21613275-5	2011	Sensitization and inhibition of RyR clusters shortened and lengthened, respectively, the median interval between consecutive Ca(2+) sparks (caffeine 239 ms; control 280 ms; tetracaine 453 ms).	Tetracaine	173-183	ryanodine receptor 2	Rattus norvegicus	32-35	
23177664-7	2013	In RA, caffeine caused contraction that was attenuated by the RyR antagonists ryanodine (10muM) and tetracaine (100muM).	Tetracaine	100-110	ryanodine receptor 2	Rattus norvegicus	62-65	
15795312-5	2005	The RyR antagonists ruthenium red, ryanodine, tetracaine, and dantrolene greatly inhibited submaximal noradrenaline- and hypoxia-induced Ca2+ release and contraction in freshly isolated rat PASMCs, but did not affect ATP-induced Ca2+ release in cultured human PASMCs.	Tetracaine	46-56	ryanodine receptor 2	Rattus norvegicus	4-7	
11463625-9	2001	The ryanodine receptor (RyR) blockers tetracaine and Mg(2+) transiently suppressed the frequency of sparks.	Tetracaine	38-48	ryanodine receptor 2	Rattus norvegicus	4-22	
11463625-9	2001	The ryanodine receptor (RyR) blockers tetracaine and Mg(2+) transiently suppressed the frequency of sparks.	Tetracaine	38-48	ryanodine receptor 2	Rattus norvegicus	24-27	
33596151-8	2021	Tet exerted a greater inhibitory effect on the DHPR signal to RyR than 3 Mg, although their inhibitory effects on RyR were almost similar.	Tetracaine	0-3	ryanodine receptor 2	Rattus norvegicus	62-65	
26537441-4	2016	Only Ca-sensitising leak can be reversed by traditional RyR inhibitors such as tetracaine.	Tetracaine	79-89	ryanodine receptor 2	Rattus norvegicus	56-59	
26851245-6	2016	PDE4 inhibition potentiated RyR2 and PLB phosphorylation at specific PKA and CaMKII sites increasing sarcoplasmic reticulum (SR) Ca(2+) load and SR Ca(2+) leak measured in a 0Na(+)/0Ca(2+) solution +- tetracaine.	Tetracaine	198-211	ryanodine receptor 2	Rattus norvegicus	28-32