PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26851245-6 2016 PDE4 inhibition potentiated RyR2 and PLB phosphorylation at specific PKA and CaMKII sites increasing sarcoplasmic reticulum (SR) Ca(2+) load and SR Ca(2+) leak measured in a 0Na(+)/0Ca(2+) solution +- tetracaine. Tetracaine 198-211 ryanodine receptor 2 Rattus norvegicus 28-32 23177664-7 2013 In RA, caffeine caused contraction that was attenuated by the RyR antagonists ryanodine (10muM) and tetracaine (100muM). Tetracaine 100-110 ryanodine receptor 2 Rattus norvegicus 62-65 26537441-4 2016 Only Ca-sensitising leak can be reversed by traditional RyR inhibitors such as tetracaine. Tetracaine 79-89 ryanodine receptor 2 Rattus norvegicus 56-59 23911439-10 2013 Interestingly, tetracaine and carvedilol used to reduce ryanodine receptor (RyR) diastolic Ca(2+) release, and ruthenium red used to prevent Ca(2+) entry into the mitochondria prevented RP-induced cell death, whereas PI3K inhibition with Wortmannin exacerbated pacing-induced cell mortality. Tetracaine 15-25 ryanodine receptor 2 Rattus norvegicus 56-74 23911439-10 2013 Interestingly, tetracaine and carvedilol used to reduce ryanodine receptor (RyR) diastolic Ca(2+) release, and ruthenium red used to prevent Ca(2+) entry into the mitochondria prevented RP-induced cell death, whereas PI3K inhibition with Wortmannin exacerbated pacing-induced cell mortality. Tetracaine 15-25 ryanodine receptor 2 Rattus norvegicus 76-79 15795312-5 2005 The RyR antagonists ruthenium red, ryanodine, tetracaine, and dantrolene greatly inhibited submaximal noradrenaline- and hypoxia-induced Ca2+ release and contraction in freshly isolated rat PASMCs, but did not affect ATP-induced Ca2+ release in cultured human PASMCs. Tetracaine 46-56 ryanodine receptor 2 Rattus norvegicus 4-7 21613275-5 2011 Sensitization and inhibition of RyR clusters shortened and lengthened, respectively, the median interval between consecutive Ca(2+) sparks (caffeine 239 ms; control 280 ms; tetracaine 453 ms). Tetracaine 173-183 ryanodine receptor 2 Rattus norvegicus 32-35 11463625-9 2001 The ryanodine receptor (RyR) blockers tetracaine and Mg(2+) transiently suppressed the frequency of sparks. Tetracaine 38-48 ryanodine receptor 2 Rattus norvegicus 4-22 11463625-9 2001 The ryanodine receptor (RyR) blockers tetracaine and Mg(2+) transiently suppressed the frequency of sparks. Tetracaine 38-48 ryanodine receptor 2 Rattus norvegicus 24-27 33596151-8 2021 Tet exerted a greater inhibitory effect on the DHPR signal to RyR than 3 Mg, although their inhibitory effects on RyR were almost similar. Tetracaine 0-3 ryanodine receptor 2 Rattus norvegicus 62-65