PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22607682-3	2012	Library preparation of related analogs allowed the establishment of additional SAR understanding and in particular the requirement for a key hydrogen bond donor motif at the 4-position of the phenyl ring in compounds such as indole 19.	indole	225-231	sarcosine dehydrogenase	Homo sapiens	79-82	
23681056-5	2013	With the aid of co-crystal structures of two discovered inhibitors (compounds 19 and 25) with BACE1, we explored the SAR around the indole and aryl groups, and obtained several BACE1 inhibitors about 1,000-fold more potent than the initial fragment hit.	indole	132-138	sarcosine dehydrogenase	Homo sapiens	117-120	
18308566-1	2008	We report herein the SAR studies of a series of indole- and indolizine-glyoxylamides that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes.	indole	48-54	sarcosine dehydrogenase	Homo sapiens	21-24	
22104146-2	2012	Development of SAR at the C2 position of indole lead 1, a palm site inhibitor of HCV NS5B polymerase (NS5B IC(50)=0.053muM, replicon EC(50)=4.8muM), is described.	indole	41-47	sarcosine dehydrogenase	Homo sapiens	15-18	
20074949-1	2010	SAR studies at the N(1)-position of allosteric indole-based HCV NS5B inhibitors has led to the discovery of acetamide derivatives with good cellular potency in subgenomic replicons (EC(50) <200 nM).	indole	47-53	sarcosine dehydrogenase	Homo sapiens	0-3	
19914828-3	2010	SAR studies focused on the discovery of novel alicyclic moieties appended to an indole core to optimize potency, physical properties and off-target activities.	indole	80-86	sarcosine dehydrogenase	Homo sapiens	0-3	
19914828-4	2010	Subsequent SAR on the N-benzyl substituent of the indole led to the discovery of compound 39 (AM679) which showed potent inhibition of leukotrienes in human blood and in a rodent bronchoalvelolar lavage (BAL) challenge model.	indole	50-56	sarcosine dehydrogenase	Homo sapiens	11-14	
19769332-4	2009	Systematic replacement of each of the unfused carbon atoms in the phenyl ring of the indole moiety by a nitrogen atom provided four different azaindole derivatives that displayed a clear SAR for antiviral activity and all of which displayed marked improvements in pharmaceutical properties.	indole	85-91	sarcosine dehydrogenase	Homo sapiens	187-190	
17512197-0	2007	Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.	indole	63-69	sarcosine dehydrogenase	Homo sapiens	14-17	
17512197-4	2007	Further elucidation of the SAR led to the identification of benzofuran and indole based templates.	indole	75-81	sarcosine dehydrogenase	Homo sapiens	27-30	
15546707-1	2004	Part 1: SAR studies of the 7-position of the indole ring.	indole	45-51	sarcosine dehydrogenase	Homo sapiens	8-11	
15186849-3	2004	A SAR study was carried out by modification of the substitutions on the indole and benzene rings.	indole	72-78	sarcosine dehydrogenase	Homo sapiens	2-5	
12729661-2	2003	The synthesis and SAR of indolizine, indole and pyrazolopyridine based compounds are now described.	indole	37-43	sarcosine dehydrogenase	Homo sapiens	18-21	
31303995-2	2019	SAR exploration revealed that 5-Cl and the sulfonyl side chain of the indole scaffold are crucial for anti-RSV activity.	indole	70-76	sarcosine dehydrogenase	Homo sapiens	0-3