PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30028988-0	2018	In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury.	flupirtine	96-106	N-acetyltransferase 2	Homo sapiens	71-92	
30028988-5	2018	Using recombinant enzymes, we found that D-13223 was formed from flupirtine via hydrolysis by carboxylesterase 2 (CES2) and subsequent acetylation by N-acetyltransferase (NAT) 2.	flupirtine	65-75	N-acetyltransferase 2	Homo sapiens	150-177	
30028988-7	2018	The formation of the NAC conjugate in liver S9 samples from NAT2 slow acetylators was significantly higher than that from NAT2 rapid/intermediate acetylators, indicating that NAT2 could function as a detoxification enzyme for flupirtine.	flupirtine	226-236	N-acetyltransferase 2	Homo sapiens	60-64	
30028988-9	2018	NAT2 slow acetylators with high CES2 activity could be highly susceptible to flupirtine-induced liver injury.	flupirtine	77-87	N-acetyltransferase 2	Homo sapiens	0-4