PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25869780-9 2015 Furthermore, flupirtine (10mg/kg and 25mg/kg) treatment significantly decreased the expression of Bax and increased the p-Akt and p-GSK-3beta, and flupirtine (25mg/kg) treatment up-regulated the p-Erk1/2 in the hippocampus of CRS mice. flupirtine 13-23 thymoma viral proto-oncogene 1 Mus musculus 122-125 25869780-10 2015 These results suggested that flupirtine exerted protective effects on the CRS-induced cognitive impairment and hippocampal neuronal apoptosis, which is possibly associated with the activation of Akt/GSK-3beta and Erk1/2 signaling pathways. flupirtine 29-39 thymoma viral proto-oncogene 1 Mus musculus 195-198