PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30028988-0	2018	In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury.	flupirtine	96-106	carboxylesterase 2	Homo sapiens	48-66	
30028988-5	2018	Using recombinant enzymes, we found that D-13223 was formed from flupirtine via hydrolysis by carboxylesterase 2 (CES2) and subsequent acetylation by N-acetyltransferase (NAT) 2.	flupirtine	65-75	carboxylesterase 2	Homo sapiens	94-112	
30028988-5	2018	Using recombinant enzymes, we found that D-13223 was formed from flupirtine via hydrolysis by carboxylesterase 2 (CES2) and subsequent acetylation by N-acetyltransferase (NAT) 2.	flupirtine	65-75	carboxylesterase 2	Homo sapiens	114-118	
30028988-6	2018	A conjugate of N-acetyl-l-cysteine (NAC), a nucleophile, was detected by incubation of flupirtine with CES2, and the conjugate formation in human liver microsomes was inhibited by CES2 inhibitors, indicating that a reactive metabolite, which may be a quinone diimine, was produced in the process of CES2-mediated hydrolysis of flupirtine.	flupirtine	87-97	carboxylesterase 2	Homo sapiens	103-107	
30028988-8	2018	CES2-overexpressing HepG2 cells showed remarkable lactate dehydrogenase leakage under flupirtine treatment, while no cytotoxicity was observed in control cells, suggesting that the reactive metabolite formed by CES2-mediated hydrolysis of flupirtine would be a trigger of hepatotoxicity.	flupirtine	86-96	carboxylesterase 2	Homo sapiens	0-4	
30028988-8	2018	CES2-overexpressing HepG2 cells showed remarkable lactate dehydrogenase leakage under flupirtine treatment, while no cytotoxicity was observed in control cells, suggesting that the reactive metabolite formed by CES2-mediated hydrolysis of flupirtine would be a trigger of hepatotoxicity.	flupirtine	86-96	carboxylesterase 2	Homo sapiens	211-215	
30028988-8	2018	CES2-overexpressing HepG2 cells showed remarkable lactate dehydrogenase leakage under flupirtine treatment, while no cytotoxicity was observed in control cells, suggesting that the reactive metabolite formed by CES2-mediated hydrolysis of flupirtine would be a trigger of hepatotoxicity.	flupirtine	239-249	carboxylesterase 2	Homo sapiens	0-4	
30028988-8	2018	CES2-overexpressing HepG2 cells showed remarkable lactate dehydrogenase leakage under flupirtine treatment, while no cytotoxicity was observed in control cells, suggesting that the reactive metabolite formed by CES2-mediated hydrolysis of flupirtine would be a trigger of hepatotoxicity.	flupirtine	239-249	carboxylesterase 2	Homo sapiens	211-215	
30028988-9	2018	NAT2 slow acetylators with high CES2 activity could be highly susceptible to flupirtine-induced liver injury.	flupirtine	77-87	carboxylesterase 2	Homo sapiens	32-36