PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11921051-9 2002 Flupirtine upregulates Bcl-2, increases glutathione levels, activates an inwardly rectifying potassium channel, and delays loss of intermitochondrial membrane calcium retention capacity. flupirtine 0-10 BCL2 apoptosis regulator Homo sapiens 23-28 18832577-7 2008 Although flupirtine was shown previously to increase neuronal survival by Bcl-2 up-regulation, this mechanism does not appear to play a role in flupirtine-mediated protection of retinal ganglion cells either in vitro or in vivo. flupirtine 9-19 BCL2 apoptosis regulator Homo sapiens 74-79 9191602-12 1997 Treatment of RPE cells in serum-free medium with flupirtine (flupirtine gluconate, 100 microM) for 72 hours caused an upregulation of bcl-2 protein. flupirtine 49-59 BCL2 apoptosis regulator Homo sapiens 134-139