PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21619452-5	2011	MATERIALS AND METHODS: In cell cultures, we investigated the effects of forskolin/3-isobutyl-1-methylxanthine (IBMX) on stimulated p53 of ALL cell lines.	1-Methyl-3-isobutylxanthine	82-109	tumor protein p53	Homo sapiens	131-134	
21619452-5	2011	MATERIALS AND METHODS: In cell cultures, we investigated the effects of forskolin/3-isobutyl-1-methylxanthine (IBMX) on stimulated p53 of ALL cell lines.	1-Methyl-3-isobutylxanthine	111-115	tumor protein p53	Homo sapiens	131-134	
16614702-4	2006	RESULTS: All the derivatives, except 3-isobutyl-methylxanthine, increased tumor cell sensitization to radiation by inducing apoptosis in the p53-null lung cancer cell line.	1-Methyl-3-isobutylxanthine	37-62	tumor protein p53	Homo sapiens	141-144	
16614702-6	2006	In contrast, 3-isobutyl-methylxanthine was more potent than the other derivatives in radiosensitization of normal lung epithelial cells and the lung carcinoma cells stably transfected with wild-type p53.	1-Methyl-3-isobutylxanthine	13-38	tumor protein p53	Homo sapiens	199-202	
16614702-8	2006	CONCLUSION: Our results suggest that 3-isobutyl-methylxanthine might function through a p53-dependent mechanism.	1-Methyl-3-isobutylxanthine	37-62	tumor protein p53	Homo sapiens	88-91	
9766444-6	1998	The differentiation response to transfected p53 with or without INF-gamma was inhibited by cyclic adenosine monophosphate (cAMP)-inducing agents (dibutyryl cyclic adenosine 3":5"-monophosphate, forskolin, and 3-isobutyl-1-methylxanthine) in a dose-dependent manner.	1-Methyl-3-isobutylxanthine	209-236	tumor protein p53	Homo sapiens	44-47