PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12097411-2	2002	We reported previously that aerosolized Syk antisense oligodeoxynucleotides (ASO) depresses Syk expression in inflammatory cells, the release of mediators from alveolar macrophages, and pulmonary inflammation.	1,5-anhydroglucitol	77-80	spleen associated tyrosine kinase	Rattus norvegicus	40-43	
12097411-2	2002	We reported previously that aerosolized Syk antisense oligodeoxynucleotides (ASO) depresses Syk expression in inflammatory cells, the release of mediators from alveolar macrophages, and pulmonary inflammation.	1,5-anhydroglucitol	77-80	spleen associated tyrosine kinase	Rattus norvegicus	92-95	
12097411-4	2002	Syk ASO, delivered in a liposome, carrier/lipid complex by aerosol to rats, significantly inhibited the Ag-induced inflammatory cell infiltrate in the bronchoalveolar space, decreasing both neutrophilia and eosinophilia.	1,5-anhydroglucitol	4-7	spleen associated tyrosine kinase	Rattus norvegicus	0-3	
12097411-6	2002	Syk ASO also depressed up-regulation of the expression of beta(2) integrins, alpha(4) integrin, and ICAM-1 in bronchoalveolar lavage leukocytes and reversed the Ag-induced decrease in CD62L expression on neutrophils.	1,5-anhydroglucitol	4-7	spleen associated tyrosine kinase	Rattus norvegicus	0-3	
12097411-8	2002	Syk ASO also suppressed Ag-mediated contraction of the trachea in a complementary model.	1,5-anhydroglucitol	4-7	spleen associated tyrosine kinase	Rattus norvegicus	0-3	
12097411-9	2002	Thus, aerosolized Syk ASO suppresses many of the central components of allergic asthma and inflammation and may provide a new therapeutic approach.	1,5-anhydroglucitol	22-25	spleen associated tyrosine kinase	Rattus norvegicus	18-21	
10725739-3	2000	We hypothesized that Syk antisense oligodeoxynucleotides (ASO) delivered by aerosol to rat lungs in vivo would depress Syk PTK expression, mediator release from alveolar macrophages, and Syk-dependent pulmonary inflammation.	1,5-anhydroglucitol	58-61	spleen associated tyrosine kinase	Rattus norvegicus	21-24	
10725739-3	2000	We hypothesized that Syk antisense oligodeoxynucleotides (ASO) delivered by aerosol to rat lungs in vivo would depress Syk PTK expression, mediator release from alveolar macrophages, and Syk-dependent pulmonary inflammation.	1,5-anhydroglucitol	58-61	spleen associated tyrosine kinase	Rattus norvegicus	119-122	
10725739-3	2000	We hypothesized that Syk antisense oligodeoxynucleotides (ASO) delivered by aerosol to rat lungs in vivo would depress Syk PTK expression, mediator release from alveolar macrophages, and Syk-dependent pulmonary inflammation.	1,5-anhydroglucitol	58-61	spleen associated tyrosine kinase	Rattus norvegicus	119-122	
10725739-4	2000	RT-PCR and RT-in situ PCR demonstrated that aerosolized Syk ASO administration reduced Syk mRNA expression from alveolar macrophages compared with cells isolated from sham-treated rats.	1,5-anhydroglucitol	60-63	spleen associated tyrosine kinase	Rattus norvegicus	56-59	
10725739-4	2000	RT-PCR and RT-in situ PCR demonstrated that aerosolized Syk ASO administration reduced Syk mRNA expression from alveolar macrophages compared with cells isolated from sham-treated rats.	1,5-anhydroglucitol	60-63	spleen associated tyrosine kinase	Rattus norvegicus	87-90	
10725739-5	2000	Western blot analysis confirmed that Syk PTK expression was reduced after Syk ASO treatment.	1,5-anhydroglucitol	78-81	spleen associated tyrosine kinase	Rattus norvegicus	37-40	
10725739-5	2000	Western blot analysis confirmed that Syk PTK expression was reduced after Syk ASO treatment.	1,5-anhydroglucitol	78-81	spleen associated tyrosine kinase	Rattus norvegicus	74-77	
10725739-6	2000	Compared with sham-treated rats (scrambled oligodeoxynucleotide), Syk ASO treatment suppressed Fcgamma-receptor-mediated nitric oxide (86.0 +/- 8.3%) and TNF (73.1 +/- 3.1%) production by alveolar macrophages stimulated with IgG-anti-IgG complexes.	1,5-anhydroglucitol	70-73	spleen associated tyrosine kinase	Rattus norvegicus	66-69	
10725739-8	2000	Additionally, Syk ASO suppressed Ag-induced pulmonary inflammation, suggesting that Syk ASO may prove useful as an anti-inflammatory therapy in disorders such as asthma.	1,5-anhydroglucitol	18-21	spleen associated tyrosine kinase	Rattus norvegicus	14-17	
10725739-8	2000	Additionally, Syk ASO suppressed Ag-induced pulmonary inflammation, suggesting that Syk ASO may prove useful as an anti-inflammatory therapy in disorders such as asthma.	1,5-anhydroglucitol	18-21	spleen associated tyrosine kinase	Rattus norvegicus	84-87	
10725739-8	2000	Additionally, Syk ASO suppressed Ag-induced pulmonary inflammation, suggesting that Syk ASO may prove useful as an anti-inflammatory therapy in disorders such as asthma.	1,5-anhydroglucitol	88-91	spleen associated tyrosine kinase	Rattus norvegicus	14-17	
10725739-8	2000	Additionally, Syk ASO suppressed Ag-induced pulmonary inflammation, suggesting that Syk ASO may prove useful as an anti-inflammatory therapy in disorders such as asthma.	1,5-anhydroglucitol	88-91	spleen associated tyrosine kinase	Rattus norvegicus	84-87