PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27522126-2	2017	KV1.5, a voltage-gated K+ (KV) channel, is expressed in pulmonary artery smooth muscle cells (PASMC) and downregulated in PASMC in patients and animals with PH.	pasmc	94-99	potassium voltage-gated channel subfamily A member 5	Homo sapiens	0-5	
27522126-2	2017	KV1.5, a voltage-gated K+ (KV) channel, is expressed in pulmonary artery smooth muscle cells (PASMC) and downregulated in PASMC in patients and animals with PH.	pasmc	122-127	potassium voltage-gated channel subfamily A member 5	Homo sapiens	0-5	
16236819-5	2006	We have shown that acute hypoxia selectively inhibits I(K(V)) through KCNA5 channels in PASMC.	pasmc	88-93	potassium voltage-gated channel subfamily A member 5	Homo sapiens	70-75	
16236819-6	2006	Overexpression of the human KCNA5 gene increased I(K(V)) and caused membrane hyperpolarization in HEK-293, COS-7, and rat MASMC and PASMC.	pasmc	132-137	potassium voltage-gated channel subfamily A member 5	Homo sapiens	28-33	
16236819-8	2006	However, overexpression of KCNA5 in PASMC conferred its sensitivity to hypoxia.	pasmc	36-41	potassium voltage-gated channel subfamily A member 5	Homo sapiens	27-32	
16236819-9	2006	Reduction of Po(2) from 145 to 35 mmHg reduced I(K(V)) by approximately 40% in rat PASMC transfected with human KCNA5 but had no effect on I(K(V)) in KCNA5-transfected rat MASMC (or HEK and COS cells).	pasmc	83-88	potassium voltage-gated channel subfamily A member 5	Homo sapiens	112-117	
16236819-10	2006	These results indicate that KCNA5 is an important Kv channel that regulates resting membrane potential and that acute hypoxia selectively reduces KCNA5 channel activity in PASMC relative to MASMC and other cell types.	pasmc	172-177	potassium voltage-gated channel subfamily A member 5	Homo sapiens	146-151	
15140747-9	2004	Induction of apoptosis in PASMC by KCNA5 gene transfer may serve as an important strategy for preventing the progression of pulmonary vascular wall thickening and for treating patients with idiopathic pulmonary arterial hypertension (IPAH).	pasmc	26-31	potassium voltage-gated channel subfamily A member 5	Homo sapiens	35-40	
19845612-7	2009	However, acute hypoxia only reduced Kv currents in KCNA5-transfected PASMC.	pasmc	69-74	potassium voltage-gated channel subfamily A member 5	Homo sapiens	51-56	
19845612-8	2009	These results provide compelling evidence that Kv1.5 is an important hypoxia-sensitive Kv channel in PASMC, contributing to regulation of membrane potential and intracellular Ca2+ homeostasis during hypoxia.	pasmc	101-106	potassium voltage-gated channel subfamily A member 5	Homo sapiens	47-52	
19845612-9	2009	This hypoxia-sensitive mechanism essential for inhibiting Kv1.5 channel activity is exclusively present in PASMC.	pasmc	107-112	potassium voltage-gated channel subfamily A member 5	Homo sapiens	58-63	
17596340-8	2007	Compared with normal, PAH PASMC had decreased Kv current and Kv1.5 expression and increased [Ca(2+)](i), [K(+)](i), mitochondrial potential (Delta Psi m), and bcl-2 levels.	pasmc	26-31	potassium voltage-gated channel subfamily A member 5	Homo sapiens	61-66	
17267549-3	2007	Here, we report that overexpression of the Kv1.5 channel gene (KCNA5) in human PASMC and other cell lines produced a 15-pS single channel current and a large whole cell current that was sensitive to 4-aminopyridine.	pasmc	79-84	potassium voltage-gated channel subfamily A member 5	Homo sapiens	43-48	
17267549-3	2007	Here, we report that overexpression of the Kv1.5 channel gene (KCNA5) in human PASMC and other cell lines produced a 15-pS single channel current and a large whole cell current that was sensitive to 4-aminopyridine.	pasmc	79-84	potassium voltage-gated channel subfamily A member 5	Homo sapiens	63-68