PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21868450-2	2011	We have demonstrated that ANP-cyclic GMP (cGMP)-protein kinase G (PKG) signaling inhibits TGF-beta signaling by blocking TGF-beta-induced nuclear translocation of mothers against decapentaplegic homolog (Smad)3 in pulmonary artery smooth muscle cells (PASMC).	pasmc	252-257	protein kinase cGMP-dependent 1	Homo sapiens	66-69	
20646410-4	2010	Semi-quantitative reverse transcription and polymerase chain reaction (RT-PCR) and Western blot were used to examine the PKGIalpha mRNA and protein expression after PASMC were transfected by Ad-PKG.	pasmc	165-170	protein kinase cGMP-dependent 1	Homo sapiens	121-124	
21851826-10	2011	SIGNIFICANCE: Our study suggests that enhanced PKG activity suppresses calcineurin/NFATc2 cascade-mediated cyclin A expression, CDK2 activation and PASMC proliferation to contribute to the overall effects of sildenafil in the treatment of pulmonary hypertension.	pasmc	148-153	protein kinase cGMP-dependent 1	Homo sapiens	47-50	
15739122-7	2005	On the other hand, treatment of PASMC with inhibitors of cGMP-dependent protein kinase (PKG) or cAMP-dependent protein kinase (PKA) reversed the antiproliferative effect of sildenafil.	pasmc	32-37	protein kinase cGMP-dependent 1	Homo sapiens	88-91	
15739122-9	2005	This effect was partially reduced by PKG inhibition and completely abolished by PKA inhibition.We conclude that sildenafil exerts an antiproliferative effect on human PASMC that is mediated by an interaction between the cGMP-PKG and the cAMP-PKA activated pathways, leading to inhibition of PDGF-mediated activation of the ERK.	pasmc	167-172	protein kinase cGMP-dependent 1	Homo sapiens	37-40	
15739122-9	2005	This effect was partially reduced by PKG inhibition and completely abolished by PKA inhibition.We conclude that sildenafil exerts an antiproliferative effect on human PASMC that is mediated by an interaction between the cGMP-PKG and the cAMP-PKA activated pathways, leading to inhibition of PDGF-mediated activation of the ERK.	pasmc	167-172	protein kinase cGMP-dependent 1	Homo sapiens	225-228