PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21186266-3 2011 We have previously demonstrated that SERT transactivates PDGFRbeta in serotonin-stimulated PASMC proliferation. pasmc 91-96 solute carrier family 6 member 4 Homo sapiens 37-41 21186266-5 2011 The results show that four tested SERT blockers dose dependently inhibit PDGF-stimulated human and bovine PASMC proliferation with comparable efficacy to that of PDGFR inhibitors, whereas 5-HT1B or 5-HT2A receptor inhibitors had no effect. pasmc 106-111 solute carrier family 6 member 4 Homo sapiens 34-38 21186266-7 2011 Similarly, PDGF-induced PASMC proliferation was attenuated by small interfering RNA downregulation of SERT. pasmc 24-29 solute carrier family 6 member 4 Homo sapiens 102-106 21186266-11 2011 In total, the data show for the first time an important interactive relationship between SERT and the PDGFRbeta in the production of PASMC proliferation triggered by PDGF that may be important in PH. pasmc 133-138 solute carrier family 6 member 4 Homo sapiens 89-93 32141846-12 2020 It is necessary to continue research in this direction, which will reveal the molecular mechanisms by which SERT regulates PASMC proliferation and clarify the role of serotonin and its transporter in the development of PAH in children with CHD. pasmc 123-128 solute carrier family 6 member 4 Homo sapiens 108-112 23601559-3 2013 Serotonin (5-HT) has been shown to be involved in PH by inducing PASMC proliferation through the activation of 5-HT1B receptors (5-HT1BR) and 5-HT transporter (5-HTT). pasmc 65-70 solute carrier family 6 member 4 Homo sapiens 142-158