PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28484848-3 2017 Endothelin-1 (ET-1) dose- and time-dependently resulted in PPARgamma reduction and proliferation of primary cultured rat PASMC, which was accompanied by the activation of nuclear factor-kappaB (NF-kappaB) and subsequent induction of microRNA-27a/b (miR-27a/b) expression. pasmc 121-126 microRNA 27a Rattus norvegicus 233-247 28484848-7 2017 Taken together, our study demonstrates that ET-1 stimulates miR-27a/b expression by activation of the NF-kappaB pathway, which in turn results in PPARgamma reduction and contributes to ET-1-induced PASMC proliferation. pasmc 198-203 microRNA 27a Rattus norvegicus 60-67 28484848-3 2017 Endothelin-1 (ET-1) dose- and time-dependently resulted in PPARgamma reduction and proliferation of primary cultured rat PASMC, which was accompanied by the activation of nuclear factor-kappaB (NF-kappaB) and subsequent induction of microRNA-27a/b (miR-27a/b) expression. pasmc 121-126 microRNA 27a Rattus norvegicus 249-256 28484848-6 2017 Further study indicated that the presence of either NF-kappaB inhibitor pyrrolidinedithiocarbamate or prior silencing miR-27a/b with anti-miRNA oligonucleotides suppressed ET-1-induced PPARgamma reduction and proliferation of PASMC, while overexpression of miR-27a/b reduced PPARgamma expression and enhanced PASMC proliferation. pasmc 226-231 microRNA 27a Rattus norvegicus 118-125 28484848-6 2017 Further study indicated that the presence of either NF-kappaB inhibitor pyrrolidinedithiocarbamate or prior silencing miR-27a/b with anti-miRNA oligonucleotides suppressed ET-1-induced PPARgamma reduction and proliferation of PASMC, while overexpression of miR-27a/b reduced PPARgamma expression and enhanced PASMC proliferation. pasmc 309-314 microRNA 27a Rattus norvegicus 118-125