PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19132225-9	2008	Finally, upregulation of PAI-1 by Rac-1 and HIF-1 was essential for thrombin-stimulated proliferation of PASMC.	pasmc	105-110	serpin family E member 1	Homo sapiens	25-30	
19132225-10	2008	These findings indicate that Rac-1 is an important mediator of thrombin signaling and may contribute to pulmonary vascular remodeling via HIF-1-dependent upregulation of PAI-1 leading to enhanced proliferation of PASMC.	pasmc	213-218	serpin family E member 1	Homo sapiens	170-175	
18337154-3	2008	In this study, we investigated the expression and function of plasminogen activator inhibitor (PAI)-1, an inhibitor of the plasminogen activator system and target gene of the transforming growth factor (TGF)-beta1 signalling cascade, in PASMC in IPAH.	pasmc	237-242	serpin family E member 1	Homo sapiens	62-101	
18337154-6	2008	PAI-1 was also downregulated in primary PASMC derived from IPAH lungs as compared with donor-derived PASMC.	pasmc	40-45	serpin family E member 1	Homo sapiens	0-5	
18337154-9	2008	In contrast, PAI-1 knock-down with siRNA increased PASMC proliferation and decreased PASMC migration.	pasmc	51-56	serpin family E member 1	Homo sapiens	13-18	
18337154-9	2008	In contrast, PAI-1 knock-down with siRNA increased PASMC proliferation and decreased PASMC migration.	pasmc	85-90	serpin family E member 1	Homo sapiens	13-18	
18337154-10	2008	CONCLUSIONS: PAI-1 is significantly downregulated in PASMC in IPAH, on the mRNA and protein level.	pasmc	53-58	serpin family E member 1	Homo sapiens	13-18	
18337154-11	2008	PAI-1 negatively regulates PASMC proliferation, while it increases PASMC migration.	pasmc	27-32	serpin family E member 1	Homo sapiens	0-5	
18337154-11	2008	PAI-1 negatively regulates PASMC proliferation, while it increases PASMC migration.	pasmc	67-72	serpin family E member 1	Homo sapiens	0-5	
29644896-12	2018	These results suggest that miR-17~92 regulates the PASMC contractile phenotype and proliferation coordinately and synergistically by direct and indirect targeting of PAI-1.	pasmc	51-56	serpin family E member 1	Homo sapiens	166-171