PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23812635-5	2013	The present studies tested the hypothesis that Trx1 regulates hypoxia-induced PASMC proliferation via HIF and/or PI3K- and Akt-dependent mechanisms.	pasmc	78-83	thioredoxin	Homo sapiens	47-51	
23812635-8	2013	Both small-interfering RNA-mediated knockdown and pharmacological Trx1 inhibition attenuated hypoxia-induced PASMC proliferation, HIF activation, and Akt activation.	pasmc	109-114	thioredoxin	Homo sapiens	66-70	
23812635-9	2013	While Trx1 knockdown suppressed hypoxia-induced PI3K-Akt activation in PASMC, PI3K-Akt inhibition prevented hypoxia-induced proliferation but had no effect on hypoxia-induced increases in Trx1 or HIF activation.	pasmc	71-76	thioredoxin	Homo sapiens	6-10	
23812635-10	2013	Thus, our findings indicate that Trx1 contributes to hypoxia-induced PASMC proliferation by modulating HIF activation and subsequent PI3K-Akt activation.	pasmc	69-74	thioredoxin	Homo sapiens	33-37	
23812635-11	2013	These novel data suggest that Trx1 might represent a novel therapeutic target to prevent hypoxic PASMC proliferation.	pasmc	97-102	thioredoxin	Homo sapiens	30-34