PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31023188-9	2019	Downregulation of LRP1 protein was also demonstrated in explanted PASMC from patients with PAH and accompanied by enhanced TGFbeta1-pSmad3-CTGF signaling and increased TGFbeta1-induced PASMC proliferation that was prevented by pioglitazone.	pasmc	66-71	LDL receptor related protein 1	Homo sapiens	18-22	
31023188-9	2019	Downregulation of LRP1 protein was also demonstrated in explanted PASMC from patients with PAH and accompanied by enhanced TGFbeta1-pSmad3-CTGF signaling and increased TGFbeta1-induced PASMC proliferation that was prevented by pioglitazone.	pasmc	185-190	LDL receptor related protein 1	Homo sapiens	18-22	
30910704-6	2019	Depletion of LRP1 decreased proliferation of donor and IPAH PASMC in a beta1-integrin-dependent manner.	pasmc	60-65	LDL receptor related protein 1	Homo sapiens	13-17	
30910704-7	2019	Furthermore, LRP1 silencing attenuated the expression of fibronectin and collagen I and increased the levels of alpha-smooth muscle actin and myocardin in donor, but not in IPAH, PASMC.	pasmc	179-184	LDL receptor related protein 1	Homo sapiens	13-17	
30910704-9	2019	In conclusion, our results indicate that LRP1 promotes the dedifferentiation of PASMC from a contractile to a synthetic phenotype thus suggesting its contribution to vascular remodeling in PH.	pasmc	80-85	LDL receptor related protein 1	Homo sapiens	41-45