PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17197172-6	2007	1alpha,25(OH)(2)D(3) and 17beta-estradiol also induced the phosphorylation of CREB and Elk-1 transcription factors in an ERK1/2-dependent manner.	Estradiol	25-41	cAMP responsive element binding protein 1	Mus musculus	78-82	
30556190-0	2018	MicroRNA-205 affects mouse granulosa cell apoptosis and estradiol synthesis by targeting CREB1.	Estradiol	56-65	cAMP responsive element binding protein 1	Mus musculus	89-94	
30021350-0	2018	Knockdown of CREB1 promotes apoptosis and decreases estradiol synthesis in mouse granulosa cells.	Estradiol	52-61	cAMP responsive element binding protein 1	Mus musculus	13-18	
30021350-5	2018	Results of enzyme linked immunosorbent assay revealed that CREB1 knockdown significantly decreased the concentrations of estradiol (E2) and progesterone (P4) in mGCs.	Estradiol	121-130	cAMP responsive element binding protein 1	Mus musculus	59-64	
20478382-1	2010	We have previously reported in C2C12 murine skeletal muscle cells that 10(-8)M 17beta-estradiol promotes MAPKs stimulation which in turn mediates the activation of CREB and Elk-1 transcription factors.	Estradiol	79-95	cAMP responsive element binding protein 1	Mus musculus	164-168	
33681369-0	2021	lncRNA MALAT1 Regulates Mouse Granulosa Cell Apoptosis and 17beta-Estradiol Synthesis via Regulating miR-205/CREB1 Axis.	Estradiol	59-75	cAMP responsive element binding protein 1	Mus musculus	109-114	
17197172-0	2007	Activation of MAPKs by 1alpha,25(OH)2-Vitamin D3 and 17beta-estradiol in skeletal muscle cells leads to phosphorylation of Elk-1 and CREB transcription factors.	Estradiol	53-69	cAMP responsive element binding protein 1	Mus musculus	133-137	
16611827-2	2006	To study whether estrogen has a nonclassical effect on basal forebrain cholinergic system, we measured the intensity of cAMP response element-binding protein (CREB) phosphorylation (pCREB) in cholinergic neurons after administration of 17beta-estradiol to ovariectomized (OVX) mice.	Estradiol	236-252	cAMP responsive element binding protein 1	Mus musculus	120-157	
16611827-2	2006	To study whether estrogen has a nonclassical effect on basal forebrain cholinergic system, we measured the intensity of cAMP response element-binding protein (CREB) phosphorylation (pCREB) in cholinergic neurons after administration of 17beta-estradiol to ovariectomized (OVX) mice.	Estradiol	236-252	cAMP responsive element binding protein 1	Mus musculus	159-163	
12843281-3	2003	To examine whether estrogen may exert rapid actions on intracellular signaling within gonadotropin-releasing hormone (GnRH) neurons in vivo,we examined the phosphorylation status of cAMP response element-binding protein (CREB) in these cells after the administration of 17-beta-estradiol to ovariectomized (OVX) mice.	Estradiol	270-287	cAMP responsive element binding protein 1	Mus musculus	221-225