PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25795461-1	2015	We previously reported upregulation of UGT2B15 by 17beta-estradiol in breast cancer MCF7 cells via binding of the estrogen receptor alpha (ERalpha) to an estrogen response unit (ERU) in the proximal UGT2B15 promoter.	Estradiol	50-66	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	39-46	
19487245-0	2009	Estrogen receptor alpha, fos-related antigen-2, and c-Jun coordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17beta-estradiol in MCF-7 cells.	Estradiol	154-170	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	86-127	
19487245-1	2009	UDP-glucuronosyltransferase 2B15 and 2B17 expression is up-regulated by 17beta-estradiol in MCF-7 breast cancer cells, as assessed by quantitative real-time polymerase chain reaction.	Estradiol	72-88	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	0-41	
19487245-2	2009	Using 5"-deletion mapping and site-directed mutagenesis, we demonstrate that 17beta-estradiol activation of UGT2B15 gene transcription is mediated by a 282-base pair fragment positioned -454 to -172 nucleotides from the translation start site.	Estradiol	77-93	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	108-115	
19487245-8	2009	The involvement of these three transcription factors in the stimulation of UGT2B15 gene expression by 17beta-estradiol was confirmed by siRNA silencing experiments.	Estradiol	102-118	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	75-82	
19487245-10	2009	Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17beta-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity.	Estradiol	109-125	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	8-15	
16690804-3	2006	UGT2B15 is the only UGT2B enzyme up-regulated by estrogen, and marked estradiol stimulation of UGT2B15 mRNA levels is observed, in a time- and dose-dependent manner.	Estradiol	70-79	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	0-7	
16690804-3	2006	UGT2B15 is the only UGT2B enzyme up-regulated by estrogen, and marked estradiol stimulation of UGT2B15 mRNA levels is observed, in a time- and dose-dependent manner.	Estradiol	70-79	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	95-102	
16690804-4	2006	UGT2B15 stimulation by estradiol is blocked by the antiestrogen ICI182,780, but not by the translational inhibitor cycloheximide, indicating that UGT2B15 is likely a primary transcriptional response mediated through the ER.	Estradiol	23-32	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	0-7	
16690804-4	2006	UGT2B15 stimulation by estradiol is blocked by the antiestrogen ICI182,780, but not by the translational inhibitor cycloheximide, indicating that UGT2B15 is likely a primary transcriptional response mediated through the ER.	Estradiol	23-32	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	146-153	
15318931-6	2004	There was some indication that plasma estradiol and testosterone concentrations varied by UGT2B15 and SULT1A1 genotypes; women with the UGT2B15 Asp/Tyr and Tyr/Tyr genotypes had higher concentrations of estradiol than women with the Asp/Asp genotype (P = 0.004).	Estradiol	203-212	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	136-143	
25795461-1	2015	We previously reported upregulation of UGT2B15 by 17beta-estradiol in breast cancer MCF7 cells via binding of the estrogen receptor alpha (ERalpha) to an estrogen response unit (ERU) in the proximal UGT2B15 promoter.	Estradiol	50-66	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	199-206	
25795461-6	2015	Together, these data indicate that both 17beta-estradiol and the antiestrogen 4-OHTAM upregulate UGT2B15 in MCF7 cells via the same ERalpha-signaling pathway.	Estradiol	40-56	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	97-104	
23648677-5	2013	In a correlation study between sipoglitazar glucuronidation and UGT isoform-specific activities, the glucuronidation of S-oxazepam, a specific substrate for UGT2B15, strongly correlated with that of sipoglitazar, as compared with that of beta-estradiol, a representative UGT1A1 substrate.	Estradiol	238-252	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	157-164