PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22837389-4 2013 The results showed that estradiol enhances CYP2A6, CYP2B6, and CYP3A4 expression, whereas progesterone induces CYP2A6, CYP2B6, CYP2C8, CYP3A4, and CYP3A5 expression. Estradiol 24-33 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 63-69 25678418-4 2015 CYP1A2 and CYP3A4, respectively, are likely the major hepatic enzymes responsible for 2-/4-hydroxylation and 16alpha-hydroxylation of estradiol and estrone, steroids that can contribute to breast cancer risk. Estradiol 134-143 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 11-17 23223499-2 2013 Placental growth hormone (PGH), estrogens (primarily 17beta-estradiol), cortisol, and progesterone have the potential to modulate CYP3A activity. Estradiol 53-69 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 130-135 27995413-9 2017 Stromal cells isolated from ovarian endometriotic lesions expressed CYP3A4 and their exposure to luteal phase-mimicking hormones (estradiol + progesterone) reduced CYP3A4 mRNA in parallel with a diminished expression of the corresponding receptors, estrogen receptor alpha and progesterone receptor. Estradiol 130-139 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 68-74 27995413-9 2017 Stromal cells isolated from ovarian endometriotic lesions expressed CYP3A4 and their exposure to luteal phase-mimicking hormones (estradiol + progesterone) reduced CYP3A4 mRNA in parallel with a diminished expression of the corresponding receptors, estrogen receptor alpha and progesterone receptor. Estradiol 130-139 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 164-170 20621111-7 2010 CYP3A4 G-allele carriage was associated with lower levels of estrone sulphate (p=0.005) and higher levels of estradiol (p=0.04) compared to non-carriers. Estradiol 109-118 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 17570247-4 2007 Oxidation of E(2) to 2-OHE(2) is mainly catalyzed by cytochrome P450 (CYP) 1A1, and CYP3A4, whereas oxidation of E(2) to 4-OHE(2) in extrahepatic tissues is mainly catalyzed by CYP1B1 as well as some CYP3As. Estradiol 13-17 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 84-90 17636047-4 2007 We observed the protein levels of both CYP3A4 and MDR1 in PXR small interfering RNA (siRNA)-transfected cells were not increased in the presence of PXR ligands, paclitaxel, cisplatin, estradiol, or medroxyprogesterone acetate (MPA) compared with control siRNA-transfected cells. Estradiol 184-193 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 39-45 17570247-4 2007 Oxidation of E(2) to 2-OHE(2) is mainly catalyzed by cytochrome P450 (CYP) 1A1, and CYP3A4, whereas oxidation of E(2) to 4-OHE(2) in extrahepatic tissues is mainly catalyzed by CYP1B1 as well as some CYP3As. Estradiol 25-29 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 84-90 15050414-5 2004 Estradiol (E2) is usually metabolized by CYP1A1/1A2 and CYP3A4 to the 2-hydroxy estradiol (2-OHE2) and 4-hydroxy estradiol (4-OHE2) in human liver. Estradiol 0-9 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 56-62 15116059-2 2004 Although isotretinoin and estradiol are metabolized largely by cytochrome P450 (CYP) 3A4 and glucuronidation, the potential for clinical drug interaction, with subsequent pharmacodynamic impact, has not been evaluated. Estradiol 26-35 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 63-88 17936932-3 2007 OPs are potent irreversible inhibitors of testosterone metabolism by cytochrome P450 (CYP) 3A4 and of estradiol metabolism by CYP3A4 and CYP1A2. Estradiol 102-111 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 126-132 16790556-4 2006 Kinetic studies using HLM, CYP3A4, and CYP1A2 showed similar affinities (Km) for E2 with respect to 2-OHE2 production. Estradiol 81-83 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 27-33 16713641-2 2006 CYP3A plays a broad role in biotransforming both exogenous compounds and endogenous hormones such as testosterone and estradiol. Estradiol 118-127 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-5 16112414-4 2005 A major metabolite of estradiol, 2-hydroxyestradiol, is mainly catalyzed by CYP1A2 and CYP3A4 in liver, and by CYP1A1 in extrahepatic tissues. Estradiol 22-31 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 87-93 15817670-0 2005 Potential role for human cytochrome P450 3A4 in estradiol homeostasis. Estradiol 48-57 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 25-44 15817670-10 2005 This impaired lactation phenotype was associated with significantly reduced serum estradiol levels in Tg-CYP3A4 mice. Estradiol 82-91 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 105-111 9047321-0 1997 Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor. Estradiol 99-108 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 29-35 14690416-3 2003 When the activities of NVP 2-hydroxylation and CBZ 10,11-epoxidation by expressed CYP3A4 were measured in the presence of steroids, NVP 2-hydroxylation was found to be remarkably increased by aldosterone and inhibited by estradiol. Estradiol 221-230 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 82-88 12865317-8 2003 The ratio of 4- to 2-hydroxylation of 17beta-estradiol or estrone with CYP3A4 was 0.22 or 0.51, respectively. Estradiol 38-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 71-77 12166560-2 2002 Itraconazole can inhibit CYP3A, thus interfering with synthesis of gluco- and mineralocorticoids, androgens and oestradiol as well as the metabolism of budesonide. Estradiol 112-122 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 25-30 11741520-5 2001 RESULT: CYP1A2, CYP3A4, and CYP2C9 catalyze the estradiol 2-hydroxylation. Estradiol 48-57 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 16-22 11741520-10 2001 CONCLUSION: CYP1A2 and CYP3A4 are two important enzymes catalyzing the main estradiol 2-hydroxylation metabolism pathway at high substrate concentrations. Estradiol 76-85 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 23-29 11067738-0 2000 Studies on the interactions between drugs and estrogen: analytical method for prediction system of gynecomastia induced by drugs on the inhibitory metabolism of estradiol using Escherichia coli coexpressing human CYP3A4 with human NADPH-cytochrome P450 reductase. Estradiol 161-170 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 213-219 11454902-0 2001 Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5. Estradiol 54-70 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 153-172 9714305-10 1998 Similarly, estradiol 3-methyl ether is demethylated by CYP2C19 into estradiol, a CYP3A4 substrate for ortho-hydroxylation; there was significant stimulation of hydroxylation by combined 2C19 and 3A4. Estradiol 11-20 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 81-87 9047321-2 1997 In this investigation, we report that CYP3A4 requires a phenolic function for ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor and that CYP3A4 aromatic hydroxylation in general may be dependent on the presence of a free phenolic group. Estradiol 101-110 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 38-44 9047321-8 1997 The mechanism of augmentation by the phenolic hydroxyl does not appear to involve the acidic proton of estradiol, since CYP3A4-catalyzed estradiol 2-hydroxylation and testosterone 6-beta-hydroxylation were diminished to an equal extent when incubations were performed at increasing buffer pH values from 7 to 9. Estradiol 137-146 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 120-126