PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22605923-0 2012 17-beta-estradiol inhibits hyperosmolarity-induced proinflammatory cytokine elevation via the p38 MAPK pathway in human corneal epithelial cells. Estradiol 0-17 mitogen-activated protein kinase 1 Homo sapiens 94-97 22605923-6 2012 Pretreatment with 10(-10) M 17-beta-estradiol greatly inhibited the increased expression and production of IL-6, IL-1, and TNF-alpha induced by hyperosmolarity, whereas with the administration of SB203580 (10 muM), an inhibitor of the p38 pathway, the inhibiting effect of 17-beta-estradiol disappeared. Estradiol 28-45 mitogen-activated protein kinase 1 Homo sapiens 235-238 22605923-7 2012 The western blot results showed that the increased phosphorylation level of p38 caused by hyperosmolarity was greatly inhibited by 17-beta-estradiol. Estradiol 131-148 mitogen-activated protein kinase 1 Homo sapiens 76-79 21302296-6 2011 In these cells, estradiol (E(2) )/ER and synthetic androgen (R1881)/AR trans-activate EGFR leading to the downstream signaling and to ERK activation. Estradiol 16-25 mitogen-activated protein kinase 1 Homo sapiens 134-137 21538324-0 2011 17beta-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner. Estradiol 0-16 mitogen-activated protein kinase 1 Homo sapiens 64-68 20212170-3 2010 We show that dorsal hippocampal E(2) infusion increases acetylation of dorsal hippocampal histone H3, but not H4--an effect blocked by dorsal hippocampal inhibition of ERK activation. Estradiol 32-36 mitogen-activated protein kinase 1 Homo sapiens 168-171 20691769-1 2010 Activated extracellular signal-regulated kinase (ERK) signaling mediated plasticity-related gene transcription has been proposed for one possible mechanism by which 17beta-estradiol (E2) enhances synaptic plasticity and memory. Estradiol 165-181 mitogen-activated protein kinase 1 Homo sapiens 10-47 20691769-1 2010 Activated extracellular signal-regulated kinase (ERK) signaling mediated plasticity-related gene transcription has been proposed for one possible mechanism by which 17beta-estradiol (E2) enhances synaptic plasticity and memory. Estradiol 165-181 mitogen-activated protein kinase 1 Homo sapiens 49-52 19821775-3 2010 Estrogen (17beta-estradiol, 10 nM) and shear stress (12 dyn/cm(2)) alone induced transient phosphorylations of ERK and p38 MAPK in MG63 cells. Estradiol 10-26 mitogen-activated protein kinase 1 Homo sapiens 111-114 20386756-13 2010 For estradiol, we have shown rapid effects via classical estrogen receptors inhibiting ERK activation and, consequently, apoptosis. Estradiol 4-13 mitogen-activated protein kinase 1 Homo sapiens 87-90 18462857-9 2008 Instead the phytochemical reduced the amount of ERK activated by estradiol, which could be the pathway responsible for Promoter I.1 transactivation and the induced CYP19 expression. Estradiol 65-74 mitogen-activated protein kinase 1 Homo sapiens 48-51 19741198-0 2009 Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 19-22 19741198-4 2009 In freshly isolated aortic tissue, estradiol stimulated extracellular signal-regulated kinases (ERK) phosphorylation. Estradiol 35-44 mitogen-activated protein kinase 1 Homo sapiens 56-94 19741198-4 2009 In freshly isolated aortic tissue, estradiol stimulated extracellular signal-regulated kinases (ERK) phosphorylation. Estradiol 35-44 mitogen-activated protein kinase 1 Homo sapiens 96-99 19741198-5 2009 In contrast, in cultured VSMC, where GPR30 expression is significantly reduced, estradiol inhibits ERK phosphorylation. Estradiol 80-89 mitogen-activated protein kinase 1 Homo sapiens 99-102 19741198-6 2009 Transfer of the genes encoding GPR30 led to estradiol stimulation of ERK phosphorylation, which is opposite the effects of estradiol in the primary culture of VSMCs. Estradiol 44-53 mitogen-activated protein kinase 1 Homo sapiens 69-72 19741198-8 2009 Estradiol-mediated stimulation of ERK subsequent to heterologous GPR30 expression was pertussis toxin sensitive and phosphoinositide 3-kinase (PI3 kinase) dependent; under these conditions, estradiol also inhibited protein kinase A (PKA). Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 34-37 19741198-8 2009 Estradiol-mediated stimulation of ERK subsequent to heterologous GPR30 expression was pertussis toxin sensitive and phosphoinositide 3-kinase (PI3 kinase) dependent; under these conditions, estradiol also inhibited protein kinase A (PKA). Estradiol 190-199 mitogen-activated protein kinase 1 Homo sapiens 34-37 19741198-9 2009 In contrast, in the absence of GPR30 expression in cultured VSMC, estradiol stimulated PKA activity and inhibited ERK phosphorylation. Estradiol 66-75 mitogen-activated protein kinase 1 Homo sapiens 114-117 21475848-0 2009 Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells. Estradiol 10-19 mitogen-activated protein kinase 1 Homo sapiens 91-95 21475848-3 2009 Here, we report that progesterone and testosterone induce apoptosis in HUVECs in a p38- and JNK-dependent manner, and that estradiol promotes proliferation via the activation of ERK2. Estradiol 123-132 mitogen-activated protein kinase 1 Homo sapiens 178-182 21475848-8 2009 Estradiol, at physiological doses, promoted an increase in ERK2 phosphorylation that was blocked by fulvestrant. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 59-63 21475848-10 2009 In conclusion, these findings suggest that JNK has an important pro-apoptotic function following progesterone and testosterone treatment in human endothelial cells, and that ERK2 has a proliferative effect following estradiol treatment. Estradiol 216-225 mitogen-activated protein kinase 1 Homo sapiens 174-178 18620059-0 2008 Estradiol facilitates neurite maintenance by a Src/Ras/ERK signalling pathway. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 55-58 18620059-4 2008 We report that 17beta-estradiol clearly activates ERK phosphorylation in CGC cultured in low potassium via ERalpha localized in the plasma membrane and without the activation of the insulin-like growth factor-I receptor. Estradiol 15-31 mitogen-activated protein kinase 1 Homo sapiens 50-53 18620059-5 2008 17beta-estradiol activates the ERK pathway through Ras-dependent Src kinase activity. Estradiol 0-16 mitogen-activated protein kinase 1 Homo sapiens 31-34 18620059-7 2008 Moreover, we demonstrate that 17beta-estradiol-mediated ERK activation is involved in the maintenance of neuritic arborisation and neuronal morphology in proapoptotic conditions. Estradiol 30-46 mitogen-activated protein kinase 1 Homo sapiens 56-59 18215419-0 2008 17beta-estradiol rapidly mobilizes intracellular calcium from ryanodine-receptor-gated stores via a PKC-PKA-Erk-dependent pathway in the human eccrine sweat gland cell line NCL-SG3. Estradiol 0-16 mitogen-activated protein kinase 1 Homo sapiens 108-111 18058892-2 2008 In response to extracellular stimuli, such as epidermal growth factor (EGF) or 17beta-estradiol (E2), extracellular signal-regulated kinase 2 (ERK2) is phosphorylated by its upstream kinase MEK, and also phosphorylates its substrates in various regions of the cell, including the nucleus. Estradiol 79-95 mitogen-activated protein kinase 1 Homo sapiens 102-141 18058892-2 2008 In response to extracellular stimuli, such as epidermal growth factor (EGF) or 17beta-estradiol (E2), extracellular signal-regulated kinase 2 (ERK2) is phosphorylated by its upstream kinase MEK, and also phosphorylates its substrates in various regions of the cell, including the nucleus. Estradiol 79-95 mitogen-activated protein kinase 1 Homo sapiens 143-147 17959712-2 2008 Stromal cell-derived factor-1 (SDF-1) enhances extracellular signal-regulated kinases 1 and 2 (ERK1/2) activity via the transactivation of EGFR and 17beta-estradiol (E2) induces SDF-1 production to exert autocrine proliferative effects. Estradiol 148-164 mitogen-activated protein kinase 1 Homo sapiens 47-93 17803971-13 2007 The presence of the L-type Ca(2+) channel inhibitor, nifedipine (10 microM), partially inhibited 17beta-estradiol- and PPT-induced increase in phosphorylated ERK expression, whereas it induced a complete inhibition of DPN-induced increase in ERK phosphorylation. Estradiol 97-113 mitogen-activated protein kinase 1 Homo sapiens 158-161 17486077-4 2007 Treatment of the human prostate or mammary cancer cells (LNCaP or MCF-7, respectively) with nanomolar concentrations of this peptide inhibits the androgen- or estradiol-induced association between the AR or the ER and Src the Src/Erk pathway activation, cyclin D1 expression and DNA synthesis, without interfering in the receptor-dependent transcriptional activity. Estradiol 159-168 mitogen-activated protein kinase 1 Homo sapiens 230-233 18025264-4 2007 In addition, to block the ER/Src interaction, the phosphopeptide inhibits Src/Erk pathway, cyclin D1 expression, and DNA synthesis induced by estradiol or androgen or triggered by epidermal growth factor. Estradiol 142-151 mitogen-activated protein kinase 1 Homo sapiens 78-81 17803971-13 2007 The presence of the L-type Ca(2+) channel inhibitor, nifedipine (10 microM), partially inhibited 17beta-estradiol- and PPT-induced increase in phosphorylated ERK expression, whereas it induced a complete inhibition of DPN-induced increase in ERK phosphorylation. Estradiol 97-113 mitogen-activated protein kinase 1 Homo sapiens 242-245 17131305-0 2007 17beta-Estradiol differentially regulates androgen-responsive genes through estrogen receptor-beta- and extracellular-signal regulated kinase-dependent pathways in LNCaP human prostate cancer cells. Estradiol 0-16 mitogen-activated protein kinase 1 Homo sapiens 104-141 17138646-7 2007 Estradiol treatment increases basal phosphorylation of both ERK1 and ERK2 in hippocampal CA1 and prevents ischemia-induced dephosphorylation and inactivation of ERK1 and CREB, down-regulation of Bcl-2 and activation of the caspase death cascade. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 69-73 17138646-9 2007 These findings support a model whereby estradiol acts via the classical estrogen receptors and IGF-I receptors, which converge on activation of ERK/MAPK signaling and CREB to promote neuronal survival in the face of global ischemia. Estradiol 39-48 mitogen-activated protein kinase 1 Homo sapiens 144-147 17131424-0 2007 Neuroprotective effect of 17beta-estradiol against N-methyl-D-aspartate-induced retinal neurotoxicity via p-ERK induction. Estradiol 26-42 mitogen-activated protein kinase 1 Homo sapiens 108-111 16113101-5 2005 We have shown that long-term culture of MCF7 cells in medium depleted of oestrogen (LTED) results in hypersensitivity to oestradiol (E2) coinciding with elevated levels of both ERalpha phosphorylated on Ser(118) and ERK1/ERK2. Estradiol 121-131 mitogen-activated protein kinase 1 Homo sapiens 221-225 16700004-5 2006 After interacting with a specific binding site on breast cancer cell membranes, SHBG activates a specific pathway, and by cAMP induction, inhibits estradiol-mediated activation of ERK. Estradiol 147-156 mitogen-activated protein kinase 1 Homo sapiens 180-183 16049923-7 2005 17beta-Estradiol did, however, increase levels of phosphorylated extracellular signal-regulated kinase 1/2 and AKT, suggesting that activation of these prosurvival proteins may represent one mechanism for its neuroprotective action. Estradiol 0-16 mitogen-activated protein kinase 1 Homo sapiens 65-106 15924567-0 2005 17beta-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade. Estradiol 0-17 mitogen-activated protein kinase 1 Homo sapiens 97-101 15924567-5 2005 Oestradiol increases MAP kinase (MAPK) activation as indicated by ERK1 and ERK2 phosphorylation in MCF-7 cells, which in turn activates the nuclear factor kappa B (NFkappaB) signalling pathways as indicated by an increase in the p50 subunit of NFkappaB in nuclear extracts. Estradiol 0-10 mitogen-activated protein kinase 1 Homo sapiens 75-79 15557324-2 2005 To explain the mechanistic basis of this divergence, we searched for differences in the kinetics of phosphorylation and/or in the subcellular localization of ERKs in response to 17beta-estradiol in the two cell types. Estradiol 178-194 mitogen-activated protein kinase 1 Homo sapiens 158-162 15557324-3 2005 In contrast to its transient effect on ERK phosphorylation in osteocytic cells (return to base line by 30 min), 17beta-estradiol-induced ERK phosphorylation in osteoclasts was sustained for at least 24 h following exposure to the hormone. Estradiol 112-128 mitogen-activated protein kinase 1 Homo sapiens 39-42 15557324-3 2005 In contrast to its transient effect on ERK phosphorylation in osteocytic cells (return to base line by 30 min), 17beta-estradiol-induced ERK phosphorylation in osteoclasts was sustained for at least 24 h following exposure to the hormone. Estradiol 112-128 mitogen-activated protein kinase 1 Homo sapiens 137-140 15557324-4 2005 Conversion of sustained ERK phosphorylation to transient, by means of cholera toxin-induced activation of the adenylate cyclase/cAMP/protein kinase A pathway, abrogated the pro-apoptotic effect of 17beta-estradiol on osteoclasts. Estradiol 197-213 mitogen-activated protein kinase 1 Homo sapiens 24-27 15557324-5 2005 Conversely, prolongation of ERK activation in osteocytes, by means of leptomycin B-induced inhibition of ERK export from the nucleus or overexpression of a green fluorescent protein-ERK2 mutant that resides permanently in the nucleus, converted the anti-apoptotic effect of 17beta-estradiol to a pro-apoptotic one. Estradiol 274-290 mitogen-activated protein kinase 1 Homo sapiens 28-31 15199145-4 2004 MCF-7 and ZR-75-1 cells showed a rapid and sustained activation of extracellular signal-related kinase (ERK) in response to estradiol (E2) that was substantially prevented by wild-type (wt) but not mutant BRCA1. Estradiol 124-133 mitogen-activated protein kinase 1 Homo sapiens 67-102 15580310-4 2005 Here, we determined that 17beta-estradiol (E(2)) activated WOX1, p53 and ERK in COS7 fibroblasts, primary lung epithelial cells, and androgen receptor (AR)-negative prostate DU145 cells, but not in estrogen receptor (ER)-positive breast MCF7 cells. Estradiol 25-41 mitogen-activated protein kinase 1 Homo sapiens 73-76 15582272-9 2004 While ER-X appears to mediate 17alpha- and 17beta-estradiol activation of the MAPK cascade, ER-alpha, in contrast, is inhibitory to its activation. Estradiol 43-59 mitogen-activated protein kinase 1 Homo sapiens 78-82 15582272-10 2004 Estradiol activation of MAPK/ERK may be particularly relevant for neuroprotection during aging and Alzheimer"s disease. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 24-28 15582272-10 2004 Estradiol activation of MAPK/ERK may be particularly relevant for neuroprotection during aging and Alzheimer"s disease. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 29-32 15297603-5 2004 The expression of small interfering RNA targeting MAPK 1 and 2 also had a clear inhibitory effect on the estradiol-induced activation of the cyclin A promoter and also antagonized the estradiol-induced transcription directed by the estrogen response element. Estradiol 105-114 mitogen-activated protein kinase 1 Homo sapiens 50-62 15297603-5 2004 The expression of small interfering RNA targeting MAPK 1 and 2 also had a clear inhibitory effect on the estradiol-induced activation of the cyclin A promoter and also antagonized the estradiol-induced transcription directed by the estrogen response element. Estradiol 184-193 mitogen-activated protein kinase 1 Homo sapiens 50-62 15199145-4 2004 MCF-7 and ZR-75-1 cells showed a rapid and sustained activation of extracellular signal-related kinase (ERK) in response to estradiol (E2) that was substantially prevented by wild-type (wt) but not mutant BRCA1. Estradiol 124-133 mitogen-activated protein kinase 1 Homo sapiens 104-107 12782668-5 2003 Moreover, administration of 17beta-estradiol or 4-estren-3alpha,17beta-diol to ovariectomized mice induces phosphorylation of ERKs, Elk-1, and C/EBPbeta, downregulates c-Jun, and upregulates the expression of egr-1, an ERK/SRE target gene. Estradiol 28-44 mitogen-activated protein kinase 1 Homo sapiens 126-129 12782668-5 2003 Moreover, administration of 17beta-estradiol or 4-estren-3alpha,17beta-diol to ovariectomized mice induces phosphorylation of ERKs, Elk-1, and C/EBPbeta, downregulates c-Jun, and upregulates the expression of egr-1, an ERK/SRE target gene. Estradiol 28-44 mitogen-activated protein kinase 1 Homo sapiens 126-130 12388769-4 2002 17Beta-estradiol was found to rapidly activate PKC-alpha translocation and ERK-2/mitogen-activated protein kinase phosphorylation in this cell line. Estradiol 0-16 mitogen-activated protein kinase 1 Homo sapiens 75-80 12808053-1 2003 We reported previously in HepG2 cells that estradiol induces cell cycle progression throughout the G1-S transition by the parallel stimulation of both PKC-alpha and ERK signaling molecules. Estradiol 43-52 mitogen-activated protein kinase 1 Homo sapiens 165-168 12781042-1 2003 OBJECTIVES: To study extracellular signal-regulated kinase (ERK) activation in the endometrial carcinoma cell line Ishikawa with stimulation by 17-beta-estradiol, and to elucidate the role of phosphatase and tensin homologue (PTEN) and estrogen receptor (ER) subtype on the activation of ERKs. Estradiol 144-161 mitogen-activated protein kinase 1 Homo sapiens 21-58 12781042-1 2003 OBJECTIVES: To study extracellular signal-regulated kinase (ERK) activation in the endometrial carcinoma cell line Ishikawa with stimulation by 17-beta-estradiol, and to elucidate the role of phosphatase and tensin homologue (PTEN) and estrogen receptor (ER) subtype on the activation of ERKs. Estradiol 144-161 mitogen-activated protein kinase 1 Homo sapiens 60-63 12781042-4 2003 Then, ERK activation was examined after stimulation with 17-beta-estradiol. Estradiol 57-74 mitogen-activated protein kinase 1 Homo sapiens 6-9 12781042-5 2003 RESULTS: 17-beta-estradiol activated ERK cascades (mainly ERK2) in Ishikawa cells. Estradiol 9-26 mitogen-activated protein kinase 1 Homo sapiens 37-40 12781042-5 2003 RESULTS: 17-beta-estradiol activated ERK cascades (mainly ERK2) in Ishikawa cells. Estradiol 9-26 mitogen-activated protein kinase 1 Homo sapiens 58-62 12781042-6 2003 The activation of ERK increased gradually as concentration of 17-beta-estradiol also increased. Estradiol 62-79 mitogen-activated protein kinase 1 Homo sapiens 18-21 12781042-7 2003 The maximal activation of ERK2 took place 5 min after stimulation with 17-beta-estradiol. Estradiol 71-88 mitogen-activated protein kinase 1 Homo sapiens 26-30 12781042-9 2003 17-beta-estradiol activated ERK cascades in NIH3T3 fibroblasts after transient transfection of pCXN2hERalpha. Estradiol 0-17 mitogen-activated protein kinase 1 Homo sapiens 28-31 12781042-10 2003 CONCLUSIONS: 17-beta-estradiol activate ERK cascades in Ishikawa cells by integrating with ERalpha. Estradiol 13-30 mitogen-activated protein kinase 1 Homo sapiens 40-43 12781042-11 2003 Lipid phosphatase PTEN has an inhibitory role on the activation of ERK stimulated by 17-beta-estradiol in Ishikawa cells. Estradiol 85-102 mitogen-activated protein kinase 1 Homo sapiens 67-70 11960991-13 2002 This evaluation of downstream signaling revealed that E(2)-induced Erk activation is mediated by a HRG/HER-2/PKC-delta/Ras pathway that could be crucial for E(2)-dependent growth-promoting effects in early stages of tumor progression. Estradiol 54-58 mitogen-activated protein kinase 1 Homo sapiens 67-70 11960991-5 2002 In this study, we have shown that E(2) induces a slow but persistent activation of Erk in MCF-7 breast carcinoma cells. Estradiol 34-38 mitogen-activated protein kinase 1 Homo sapiens 83-86 11960991-13 2002 This evaluation of downstream signaling revealed that E(2)-induced Erk activation is mediated by a HRG/HER-2/PKC-delta/Ras pathway that could be crucial for E(2)-dependent growth-promoting effects in early stages of tumor progression. Estradiol 157-161 mitogen-activated protein kinase 1 Homo sapiens 67-70 11960991-6 2002 The E(2)-induced Erk activation is dependent on new protein synthesis, suggesting that E(2)-induced growth factors play a major role in Erk activation. Estradiol 4-8 mitogen-activated protein kinase 1 Homo sapiens 17-20 11960991-6 2002 The E(2)-induced Erk activation is dependent on new protein synthesis, suggesting that E(2)-induced growth factors play a major role in Erk activation. Estradiol 4-8 mitogen-activated protein kinase 1 Homo sapiens 136-139 11735115-3 2001 Here, we provide evidence that two members of the mitogen-activated protein kinase family, extracellular signal-regulated kinase-1 and -2 (ERK1/2) can differentially regulate FSH-stimulated estradiol and progesterone production. Estradiol 190-199 mitogen-activated protein kinase 1 Homo sapiens 91-137 11960991-6 2002 The E(2)-induced Erk activation is dependent on new protein synthesis, suggesting that E(2)-induced growth factors play a major role in Erk activation. Estradiol 87-91 mitogen-activated protein kinase 1 Homo sapiens 17-20 11960991-6 2002 The E(2)-induced Erk activation is dependent on new protein synthesis, suggesting that E(2)-induced growth factors play a major role in Erk activation. Estradiol 87-91 mitogen-activated protein kinase 1 Homo sapiens 136-139 11960991-10 2002 In contrast, epidermal growth factor receptor (Ab528) antibody only blocked 10-20% of E(2)-induced Erk activation, suggesting that E(2)-induced Erk activation is predominantly mediated through the secretion of HRG and activation of HER-2 by an autoctine/paracrine mechanism. Estradiol 86-90 mitogen-activated protein kinase 1 Homo sapiens 99-102 11960991-10 2002 In contrast, epidermal growth factor receptor (Ab528) antibody only blocked 10-20% of E(2)-induced Erk activation, suggesting that E(2)-induced Erk activation is predominantly mediated through the secretion of HRG and activation of HER-2 by an autoctine/paracrine mechanism. Estradiol 131-135 mitogen-activated protein kinase 1 Homo sapiens 144-147 11960991-11 2002 Inhibition of PKC-delta-mediated signaling by a dominant negative mutant or the relatively specific PKC-delta inhibitor rottlerin blocked most of the E(2)-induced Erk activation but had no effect on TGF alpha-induced Erk activation. Estradiol 150-154 mitogen-activated protein kinase 1 Homo sapiens 163-166 10328986-4 1999 17beta-Estradiol elicits rapid (within 5-15 min) and sustained (at least 2 h) tyrosine phosphorylation and activation of the MAP kinases, extracellular-signal regulated kinase (ERK)1, and ERK2, which is successfully inhibited by the MAP kinase/ERK kinase 1 inhibitor PD98059, but not by the estrogen receptor (ER) antagonist ICI 182,780 and also does not appear to result from estradiol-induced activation of trk. Estradiol 0-16 mitogen-activated protein kinase 1 Homo sapiens 188-192 11355744-2 2001 After a 24-hour exposure SW-13 cells incubated with 10(-5) M concentrations of 17beta-estradiol, its 2-hydroxy or its 2-methoxy derivative, all had elevated ERK activities (196%, 159%, and 275%, respectively) relative to control cells (p < 0.01). Estradiol 79-95 mitogen-activated protein kinase 1 Homo sapiens 157-160 11032808-1 2000 Treatment of human prostate carcinoma-derived LNCaP cells with androgen or oestradiol triggers simultaneous association of androgen receptor and oestradiol receptor beta with Src, activates the Src/Raf-1/Erk-2 pathway and stimulates cell proliferation. Estradiol 75-85 mitogen-activated protein kinase 1 Homo sapiens 204-209 10228164-1 1999 The recent findings that oestradiol and progestins activate the Src/Ras/Erks signalling pathway raise the question of the role of this stimulation. Estradiol 25-35 mitogen-activated protein kinase 1 Homo sapiens 72-76 9952396-4 1999 Estradiol elicited rapid (within 5-15 min) tyrosine phosphorylation/activation of the mitogen-activated protein (MAP) kinases, ERK1 and ERK2, that persisted for at least 2 hr. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 136-140 8813150-7 1996 Estradiol treatment of subconfluent Caco-2 cells rapidly and reversibly stimulates four important intermediates in a signal transduction pathway that is known to trigger cell proliferation: two members of the large family of c-src-related tyrosine kinases, c-src and c-yes, and two serine/threonine kinases, the mitogen-activated protein (MAP) kinases, erk-1 and erk-2. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 363-368 9494073-10 1998 AII-stimulation of ET-1 transcription was critically dependent on stimulation of mitogen-activated protein kinase (erk) activity, inhibited by oestradiol and progesterone. Estradiol 143-153 mitogen-activated protein kinase 1 Homo sapiens 115-118 9275096-2 1997 We show here, that in the human neuroblastoma cell line SK-N-SH, the membrane impermeable conjugated 17beta-estradiol (E2BSA) activates mitogen activated protein kinase kinase (MAPKK or MEK) and induces the phosphorylation and activation of both ERK-1 and ERK-2 (mitogen activated protein kinase or MAPK). Estradiol 101-117 mitogen-activated protein kinase 1 Homo sapiens 256-261 34609142-0 2021 17beta-Estradiol Enhances Porcine Meiosis Resumption from Autophagy-Induced Gap Junction Intercellular Communications and Connexin 43 Phosphorylation via the MEK/ERK Signaling Pathway. Estradiol 0-16 mitogen-activated protein kinase 1 Homo sapiens 162-165 8635462-5 1996 It is only after introduction of the human wild-type 67 kDa estradiol receptor cDNA that Cos cells become estradiol-responsive in terms of erk-2 activity. Estradiol 60-69 mitogen-activated protein kinase 1 Homo sapiens 139-144 34877243-3 2021 Different studies show that down regulation of estrogen receptor beta (ERbeta) associates with GPR30 over-expression both in human testicular carcinoma in situ (CIS) and seminomas and that the mitogenic role exerted by 17beta-oestradiol induces the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) through GPR30. Estradiol 219-236 mitogen-activated protein kinase 1 Homo sapiens 263-304 8635462-2 1996 Under conditions of estradiol-dependent growth, estradiol treatment of human mammary cancer MCF-7 cells triggers rapid and transient activation of the mitogen-activated (MAP) kinases, erk-1 and erk-2, increases the active form of p21ras, tyrosine phosphorylation of Shc and p190 protein and induces association of p190 to p21ras-GAP. Estradiol 48-57 mitogen-activated protein kinase 1 Homo sapiens 194-199 34571396-6 2021 In addition, we found that E2 significantly upregulated the mRNA levels of epidermal growth (EGF)-like factors in goat cumulus cells through GPER, and activated the downstream EGF receptor (EGFR) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways. Estradiol 27-29 mitogen-activated protein kinase 1 Homo sapiens 200-241 34371773-7 2021 Consistently, the expression of ERK, PI3K, AKT, and ERalpha increased following treatment with schisandrol A; this effect was slightly better than that of E2 and was mitigated by ICI. Estradiol 155-157 mitogen-activated protein kinase 1 Homo sapiens 32-35 34461224-10 2021 Simvastatin also inhibited E2 downstream signaling, including ERK and AKT pathways, E2/ER transcriptional activity and E2-responsive genes. Estradiol 27-29 mitogen-activated protein kinase 1 Homo sapiens 62-65 34031786-12 2021 The decreased ERK phosphorylation was reversed by testosterone or 17b-estradiol. Estradiol 66-79 mitogen-activated protein kinase 1 Homo sapiens 14-17 33895548-9 2021 On the contrary, it was inhibited by the pre-treatment of U0126 or SB203580, an ERK or a p38 inhibitor, respectively, suggesting that E2-induced endothelial exocytosis is non-genomically mediated by the MAP kinase pathway. Estradiol 134-136 mitogen-activated protein kinase 1 Homo sapiens 80-83 33409875-5 2021 In addition, E2 not only activated ERK signaling pathway but also inhibited p65 phosphorylation along with its translocation from nucleus to the cytoplasm, and subsequently inhibiting GRP78 expression, which led to inhibition of cell apoptosis. Estradiol 13-15 mitogen-activated protein kinase 1 Homo sapiens 35-38 33409875-6 2021 Together, these findings highlight the novel mechanism underlying E2-mediated improvement in endometrial angiogenesis through the ERK-p65 signaling pathway. Estradiol 66-68 mitogen-activated protein kinase 1 Homo sapiens 130-133 33640015-11 2021 Additionally, inhibiting E2-induced ERK/MAPK activation and early growth response 1 (EGR1) transcription prevents the E2-induced increase in TGFbeta1 and TGFbeta2 transcription and translation. Estradiol 25-27 mitogen-activated protein kinase 1 Homo sapiens 36-39 33849823-0 2021 [Estradiol activates ERK phosphorylation by binding to ERbeta to inhibit proliferation and promote apoptosis of human chondrocytes]. Estradiol 1-10 mitogen-activated protein kinase 1 Homo sapiens 21-24 33849823-9 2021 OBJECTIVE: The binding of E2 to ERbeta promotes ER stress and apoptosis in human chondrocytes by activating ERK pathway phosphorylation inhibit cell proliferation. Estradiol 26-28 mitogen-activated protein kinase 1 Homo sapiens 108-111 33640015-7 2021 To identify the necessary cell signaling proteins in E2-induced TGFbeta1 and TGFbeta2 transcription, human dermal fibroblasts were pre-treated with an inhibitor of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway, U0126. Estradiol 53-55 mitogen-activated protein kinase 1 Homo sapiens 240-243 33640015-11 2021 Additionally, inhibiting E2-induced ERK/MAPK activation and early growth response 1 (EGR1) transcription prevents the E2-induced increase in TGFbeta1 and TGFbeta2 transcription and translation. Estradiol 118-120 mitogen-activated protein kinase 1 Homo sapiens 36-39 32141941-7 2020 The upregulation of p-ERK, p-JNK, and p-p38 with high osmolarity was inhibited partially by DHT, but 17-beta-estradiol pretreatment only affected p-p38 for a short time interval. Estradiol 101-118 mitogen-activated protein kinase 1 Homo sapiens 148-151 32487604-2 2020 The Gs-coupled seven-transmembrane receptor GPR30 is known as both a CCL18 and an estrogen receptor; its activation by estradiol leads to a transactivation of membrane-tethered pro-heparin-binding EGF-like growth factor and the MAPK/ERK pathway. Estradiol 119-128 mitogen-activated protein kinase 1 Homo sapiens 233-236 31475206-13 2019 The effects of 17beta-estradiol were abrogated by blocking ERK signaling pathway. Estradiol 15-31 mitogen-activated protein kinase 1 Homo sapiens 59-62 31401382-0 2019 Estradiol inhibits fMLP-induced neutrophil migration and superoxide production by upregulating MKP-2 and dephosphorylating ERK. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 123-126 27188489-30 2016 Estrogen (17beta-estradiol) can promote the proliferation of HaCaT cells by increasing the expression of PCNA via activating ERK/Akt signaling pathway. Estradiol 10-26 mitogen-activated protein kinase 1 Homo sapiens 125-128 30866584-2 2019 By quantitative PCR (qPCR), western blot, immunofluorescence analysis, ELISA and ChIP assays, we demonstrated that 17beta-estradiol (E2) and the G protein estrogen receptor (GPER) agonist G-1 induce the up-regulation and secretion of FGF2 via GPER together with the EGFR/ERK/c-fos/AP-1 signaling cascade in (ER)-negative primary CAFs. Estradiol 115-131 mitogen-activated protein kinase 1 Homo sapiens 271-274 27689466-5 2017 The proliferation assay showed that 17beta-estradiol (E2) induced cell proliferation via activation of Akt and extracellular signal-regulated kinase (ERK) cascades, while shRNA mediated downregulation of ERalpha inhibited the cell proliferation. Estradiol 36-52 mitogen-activated protein kinase 1 Homo sapiens 111-148 27689466-5 2017 The proliferation assay showed that 17beta-estradiol (E2) induced cell proliferation via activation of Akt and extracellular signal-regulated kinase (ERK) cascades, while shRNA mediated downregulation of ERalpha inhibited the cell proliferation. Estradiol 36-52 mitogen-activated protein kinase 1 Homo sapiens 150-153 27689466-5 2017 The proliferation assay showed that 17beta-estradiol (E2) induced cell proliferation via activation of Akt and extracellular signal-regulated kinase (ERK) cascades, while shRNA mediated downregulation of ERalpha inhibited the cell proliferation. Estradiol 54-56 mitogen-activated protein kinase 1 Homo sapiens 111-148 27689466-5 2017 The proliferation assay showed that 17beta-estradiol (E2) induced cell proliferation via activation of Akt and extracellular signal-regulated kinase (ERK) cascades, while shRNA mediated downregulation of ERalpha inhibited the cell proliferation. Estradiol 54-56 mitogen-activated protein kinase 1 Homo sapiens 150-153 25255977-9 2016 An ERK inhibitor significantly enhanced estradiol-induced OPG expression, whereas a p38 inhibitor markedly attenuated this expression. Estradiol 40-49 mitogen-activated protein kinase 1 Homo sapiens 3-6 26938432-6 2016 Western blot analysis demonstrated the activation of Akt, Erk and upregulation of PCNA in HaCaT cells treated with 17 beta-estradiol. Estradiol 115-132 mitogen-activated protein kinase 1 Homo sapiens 58-61 26938432-8 2016 Upregulation of PCNA expression, elevated proliferation and high S phase fraction of HaCaT cell by 17 beta-estradiol could be reversed by an Akt or Erk inhibitor. Estradiol 99-116 mitogen-activated protein kinase 1 Homo sapiens 148-151 26938432-9 2016 Moreover, Erk inhibition reversed 17 beta-estradiol-induced Akt activation, whereas an Akt inhibitor exhibited no effect on Erk, further suggesting that Erk was on the upstream while Akt on the downstream of the signaling pathway. Estradiol 34-51 mitogen-activated protein kinase 1 Homo sapiens 10-13 26938432-10 2016 CONCLUSION: This study demonstrates that one of the critical mechanisms underlying 17 beta-estradiol promoting skin wound healing is through regulation of keratinocyte proliferation via Erk/Akt signaling pathway. Estradiol 83-100 mitogen-activated protein kinase 1 Homo sapiens 186-189 26689478-2 2016 We investigated the involvement of extracellular signal-regulated kinase2 (ERK2) and ERalpha in the activities of estradiol (E2), conjugated estrogens (CEs), selective estrogen receptor modulators (SERMs), and a Tissue-Selective Estrogen Complex (TSEC), a combination of a SERM and CE that has a blended activity. Estradiol 114-123 mitogen-activated protein kinase 1 Homo sapiens 35-73 26689478-2 2016 We investigated the involvement of extracellular signal-regulated kinase2 (ERK2) and ERalpha in the activities of estradiol (E2), conjugated estrogens (CEs), selective estrogen receptor modulators (SERMs), and a Tissue-Selective Estrogen Complex (TSEC), a combination of a SERM and CE that has a blended activity. Estradiol 114-123 mitogen-activated protein kinase 1 Homo sapiens 75-79 26394174-9 2015 Moreover, treatment of endometriosis xenografts with inhibitors of p38 and JNK abrogated PGE2-amplified estradiol synthesis and xenograft growth. Estradiol 104-113 mitogen-activated protein kinase 1 Homo sapiens 67-70 26062636-12 2015 While estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK, progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation, an effect that predominates over estradiol. Estradiol 6-15 mitogen-activated protein kinase 1 Homo sapiens 141-144 26225773-5 2015 Our results show that 17beta-estradiol (E2) and the selective ligand of GPER, namely G-1, induce the expression of SIRT1 through GPER and the subsequent activation of the EGFR/ERK/c-fos/AP-1 transduction pathway. Estradiol 22-38 mitogen-activated protein kinase 1 Homo sapiens 176-179 25608994-3 2014 (1) Western blot analysis was used to detect phosphorylation extracellular signal-regulated kinase 1/2(p-ERK1/2) protein expression with stimulation in different concentrations of estradiol (0.01,0.1, 1, 10, 100 micromol/L). Estradiol 180-189 mitogen-activated protein kinase 1 Homo sapiens 61-102 25950905-4 2015 Moreover, the combination of 17beta-estradiol and TCDD significantly enhanced STAT3 and P38 phosphorylation in macrophages. Estradiol 29-45 mitogen-activated protein kinase 1 Homo sapiens 88-91 25319474-0 2015 Effect of estradiol and clomiphene citrate on Erk activation in breast cancer cells. Estradiol 10-19 mitogen-activated protein kinase 1 Homo sapiens 46-49 25701261-5 2015 Treatment with ERK or Akt specific inhibitors, U0126 or LY294002, respectively, suppressed estradiol-induced growth. Estradiol 91-100 mitogen-activated protein kinase 1 Homo sapiens 15-18 24894716-4 2014 We demonstrated that 17beta-estradiol (E2) and the GPER-selective ligand G-1 triggered a GPER/EGFR/ERK/c-fos signaling pathway that leads to increased VEGF via upregulation of HIF1alpha. Estradiol 21-37 mitogen-activated protein kinase 1 Homo sapiens 99-102 24611062-5 2014 Estradiol-induced mTOR phosphorylation was preceded by rapid and transient activation of both extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) and by phosphatase and tensin homolog (PTEN) degradation. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 94-131 24611062-5 2014 Estradiol-induced mTOR phosphorylation was preceded by rapid and transient activation of both extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) and by phosphatase and tensin homolog (PTEN) degradation. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 133-136 21732360-5 2012 Here, we report that quercetin, at nutritionally relevant concentrations, mimicked the 17beta-estradiol (E2)-induced apoptotic effect in both ERbeta1-transfected HeLa and in ERbeta1-containing DLD-1 colon cancer cell lines by inducing the activation of p38. Estradiol 87-103 mitogen-activated protein kinase 1 Homo sapiens 253-256 25189390-4 2014 Moreover, we found that 17beta-estradiol protects osteocytes against apoptosis via the NO/cGMP signaling pathway: type II PKG mediates estradiol-induced activation of the prosurvival kinases Erk and Akt, whereas type I PKG contributes to prosurvival signaling by directly phosphorylating and inactivating the cell death protein BAD. Estradiol 24-40 mitogen-activated protein kinase 1 Homo sapiens 191-194 25189390-4 2014 Moreover, we found that 17beta-estradiol protects osteocytes against apoptosis via the NO/cGMP signaling pathway: type II PKG mediates estradiol-induced activation of the prosurvival kinases Erk and Akt, whereas type I PKG contributes to prosurvival signaling by directly phosphorylating and inactivating the cell death protein BAD. Estradiol 31-40 mitogen-activated protein kinase 1 Homo sapiens 191-194 23743762-0 2013 Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway. Estradiol 0-9 mitogen-activated protein kinase 1 Homo sapiens 82-85 23422279-3 2013 We first demonstrated that the enhancement of object recognition induced by E(2) was blocked by dorsal hippocampal inhibition of ERK, PI3K, or mTOR activation. Estradiol 76-80 mitogen-activated protein kinase 1 Homo sapiens 129-132 23135268-5 2012 In this study, we demonstrate for the first time that 17beta-estradiol (E2) and the selective GPER ligand G-1 regulate FASN expression and activity through the GPER-mediated signaling, which involved the EGF receptor/ERK/c-Fos/AP1 transduction pathway, as ascertained by using specific pharmacological inhibitors, performing gene-silencing experiments and ChIP assays in breast SkBr3, colorectal LoVo, hepatocarcinoma HepG2 cancer cells, and breast cancer-associated fibroblasts. Estradiol 54-70 mitogen-activated protein kinase 1 Homo sapiens 217-220 24482702-0 2014 ERK/CANP rapid signaling mediates 17beta-estradiol-induced proliferation of human breast cancer cell line MCF-7 cells. Estradiol 41-50 mitogen-activated protein kinase 1 Homo sapiens 0-3 22782019-5 2012 Osteocalcin and 17beta-estradiol mediate their effects through G protein-coupled receptors, resulting in ERK phosphorylation and activation of protein kinase-dependent signaling pathways. Estradiol 16-32 mitogen-activated protein kinase 1 Homo sapiens 105-108