PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31511352-3 2019 Here, we demonstrated that E2 widely activated adipose inflammatory factors such as fatty acid desaturase 1 (FADS1), IL6, and TNFalpha in LTED breast cancer cells. Estradiol 27-29 interleukin 6 Homo sapiens 117-120 31553636-11 2019 Gonadectomy also reduced ozone-induced expression of lung IL-6 and macrophage inflammatory protein-3 in females, which was restored by treatment with 17beta-estradiol. Estradiol 150-166 interleukin 6 Homo sapiens 58-62 31511352-5 2019 Furthermore, dexamethasone was synergistic or additive with E2 in upregulating FADS1 and IL6 expression, whereas it selectively and constantly suppressed TNFalpha expression induced by E2 in LTED breast cancer cells. Estradiol 60-62 interleukin 6 Homo sapiens 89-92 29653184-7 2018 Furthermore, the mRNA expression of inflammatory mediators such as Il-1beta, Il-6, iNos, and Cox-2 was more attenuated in 17beta-estradiol-treated group than in vehicle-treated group. Estradiol 122-138 interleukin 6 Homo sapiens 77-81 30538945-9 2018 In addition, 17-beta estradiol and progesterone suppressed the production of IL-6 in the presence and absence of poly(I:C). Estradiol 13-30 interleukin 6 Homo sapiens 77-81 31189128-0 2019 17beta-estradiol promotes endometrial cancer proliferation and invasion through IL-6 pathway. Estradiol 0-16 interleukin 6 Homo sapiens 80-84 31189128-3 2019 In this study, we provided evidence that 17beta-estradiol (E2) could significantly promote endometrial cancer cells viability, migration and invasion through activation of IL-6 pathway, which involved in its downstream pathway and target genes (p-Stat3, Bcl-2, Mcl-1, CyclinD1 and MMP2). Estradiol 41-57 interleukin 6 Homo sapiens 172-176 30029729-7 2018 The in vitro inhibition of IL-6 secretion in hMSCs by DHEA was more consistent and extensive than by estradiol or dihydrotestosterone. Estradiol 101-110 interleukin 6 Homo sapiens 27-31 29529124-8 2018 Treatment of degenerated CEP cells with 17beta-estradiol (E2) increased the expressions of aggrecan and collagen II, as well as the secretion of TGF-beta, but decreased IL-6 secretion. Estradiol 40-56 interleukin 6 Homo sapiens 169-173 29424905-11 2018 The level of serum E2 in the experimental group was positively correlated with the levels of IL-1, IL-6 and TNF-alpha in synovial fluid (p<0.05). Estradiol 19-21 interleukin 6 Homo sapiens 99-103 31938083-0 2018 Synergistic effect of estradiol and testosterone protects against IL-6-inducedcardiomyocyte apoptosismediated by TGF-beta1. Estradiol 22-31 interleukin 6 Homo sapiens 66-70 24016202-0 2014 Protective role of 17-beta-estradiol towards IL-6 leukocyte expression induced by intense training in young female athletes. Estradiol 19-36 interleukin 6 Homo sapiens 45-49 27091428-0 2016 17beta-estradiol exerts anticancer effects in anoikis-resistant hepatocellular carcinoma cell lines by targeting IL-6/STAT3 signaling. Estradiol 0-16 interleukin 6 Homo sapiens 113-117 25647267-6 2015 17beta-estradiol elevated resistin but decreased adiponectin and IL-6 levels; however, it did not alter the concentration of leptin and TNF-alpha. Estradiol 0-16 interleukin 6 Homo sapiens 65-69 24581581-10 2014 In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations. Estradiol 79-88 interleukin 6 Homo sapiens 41-45 27651177-12 2017 Interleukin 6 production was 75% higher in the estradiol than progesterone environment. Estradiol 47-56 interleukin 6 Homo sapiens 0-13 26394816-5 2016 17-beta-Estradiol inhibits the LPS-induced IL-6 inflammatory response, resulting in inhibition of NF-kappaB transcriptional activity. Estradiol 0-17 interleukin 6 Homo sapiens 43-47 25355803-6 2015 Changes in cytokine secretion (interleukin 6 [IL-6] and tumor necrosis factor alpha [TNF-alpha]) by Mphi and proliferation of ESCs in response to single and combined treatment with E2 and LPS were measured by enzyme-linked immunosorbent assay and by bromodeoxyuridine incorporation assay, respectively. Estradiol 181-183 interleukin 6 Homo sapiens 46-50 24801617-0 2014 17beta-Estradiol inhibition of IL-6-Src and Cas and paxillin pathway suppresses human mesenchymal stem cells-mediated gastric cancer cell motility. Estradiol 0-16 interleukin 6 Homo sapiens 31-35 24347287-0 2014 Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17beta-estradiol biosynthesis in endometrial carcinoma microenvironment. Estradiol 90-106 interleukin 6 Homo sapiens 49-53 24347287-6 2014 When cocultured with 17beta-estradiol (E2 )-treated cancer cells, aromatase mRNA in stromal cells was significantly elevated and increased IL-6 protein levels were detected in E2 -treated culture medium. Estradiol 21-37 interleukin 6 Homo sapiens 139-143 24609629-10 2014 Expression of the mesenchymal markers alpha-SMA and fibronectin, interleukin-6 release, and Smad2 and MLC phosphorylation induced by TGF-beta2 were all inhibited by 17beta-estradiol and progesterone. Estradiol 165-181 interleukin 6 Homo sapiens 65-78 22932481-0 2012 [17-beta estradiol promotes the expression of interleukin-6 in human periodontal ligament cells infected with Porphyromonas gingivalis]. Estradiol 1-18 interleukin 6 Homo sapiens 46-59 22642912-7 2013 The mRNA expression of osteocalcin and interleukin-6 was significantly lower in MSCs treated with estradiol than those without estradiol. Estradiol 98-107 interleukin 6 Homo sapiens 39-52 22642912-7 2013 The mRNA expression of osteocalcin and interleukin-6 was significantly lower in MSCs treated with estradiol than those without estradiol. Estradiol 127-136 interleukin 6 Homo sapiens 39-52 22213519-9 2012 CONCLUSIONS: Posttreatment interleukin-6 levels had a strong positive correlation with total-testosterone, androstenedione, and estradiol levels, suggesting that a regulation loop may emerge between these sex steroids and interleukin-6 during ADT. Estradiol 128-137 interleukin 6 Homo sapiens 222-235 23973924-11 2013 In addition, 17beta-estradiol attenuated the LPS-evoked increase in tumoral lactotroph proliferation and IL-6 release. Estradiol 13-29 interleukin 6 Homo sapiens 105-109 22213519-4 2012 RESULTS: Before ADT, serum interleukin-6 levels were inversely correlated with serum total-testosterone (rs = -0.305, P = 0.009) and dihydrotestosterone (rs = -0.380, P = 0.006) concentrations, but not correlated with adrenal androgen or estradiol levels. Estradiol 238-247 interleukin 6 Homo sapiens 27-40 22213519-9 2012 CONCLUSIONS: Posttreatment interleukin-6 levels had a strong positive correlation with total-testosterone, androstenedione, and estradiol levels, suggesting that a regulation loop may emerge between these sex steroids and interleukin-6 during ADT. Estradiol 128-137 interleukin 6 Homo sapiens 27-40 22605923-6 2012 Pretreatment with 10(-10) M 17-beta-estradiol greatly inhibited the increased expression and production of IL-6, IL-1, and TNF-alpha induced by hyperosmolarity, whereas with the administration of SB203580 (10 muM), an inhibitor of the p38 pathway, the inhibiting effect of 17-beta-estradiol disappeared. Estradiol 28-45 interleukin 6 Homo sapiens 107-111 22154464-9 2012 Interestingly, estradiol decreases IL-6 expression thereby increasing the anti-DNA response. Estradiol 15-24 interleukin 6 Homo sapiens 35-39 22605923-6 2012 Pretreatment with 10(-10) M 17-beta-estradiol greatly inhibited the increased expression and production of IL-6, IL-1, and TNF-alpha induced by hyperosmolarity, whereas with the administration of SB203580 (10 muM), an inhibitor of the p38 pathway, the inhibiting effect of 17-beta-estradiol disappeared. Estradiol 273-290 interleukin 6 Homo sapiens 107-111 22605923-8 2012 CONCLUSIONS: 17-beta-estradiol greatly inhibited the expression and production of proinflammatory cytokines IL-6, IL-1, and TNF-alpha, which were stimulated by hyperosmolarity in SV40-immortalized hCECs. Estradiol 13-30 interleukin 6 Homo sapiens 108-112 19585572-11 2009 Although female patients showed a weak negative correlation between serum IL-6 levels and estradiol levels, the lower risk of HCC in female patients cannot be fully explained by estrogen-mediated inhibition of IL-6 production. Estradiol 90-99 interleukin 6 Homo sapiens 74-78 20724602-6 2010 In confluent leukocyte-free term DCs, secreted interleukin-6 levels in incubations with estradiol-17beta were increased 2500-fold by IL-1beta (P < 0.05). Estradiol 88-104 interleukin 6 Homo sapiens 47-60 20546720-3 2010 We demonstrate that 17beta-estradiol and HM-D, a novel selective estrogen receptor modulator compound, clearly reduced the IL-6 expression levels after lipopolysaccharide exposure in ARPE-19 cells. Estradiol 20-36 interleukin 6 Homo sapiens 123-127 21046223-4 2011 RESULTS: Significant positive correlations were observed between IL-6 with age (p = 0.035), and IL-6 with estradiol on the day of hCG (p = 0.011). Estradiol 106-115 interleukin 6 Homo sapiens 96-100 18205904-3 2008 We therefore have evaluated the effect of IL-6 modulators, i.e. IL-1beta, prostaglandin E2, 17beta-estradiol, and 1,25-dihydroxyvitamin D3, on expression and synthesis of the cytokine at different stages of tumour progression. Estradiol 92-108 interleukin 6 Homo sapiens 42-46 19401270-4 2009 In these studies, the effect of 17beta-estradiol (E(2)) on the expression levels of IL-6, IL-8 and their receptors was investigated. Estradiol 32-48 interleukin 6 Homo sapiens 84-88 19401270-8 2009 Tamoxifen (Txf), an ER antagonist, completely abolished E(2)-stimulated cell growth and the expression of IL-6 and IL-8. Estradiol 56-60 interleukin 6 Homo sapiens 106-110 19401270-9 2009 IL-6/IL-8-induced cell proliferation was completely blocked by their specific neutralizing antibodies, which partially inhibited E(2)-induced cell growth. Estradiol 129-133 interleukin 6 Homo sapiens 0-4 18828896-9 2008 beta-estradiol levels were significantly higher in women having fertility disorders as compared to fertile women and have significant correlations (r = 0.65; P < 0.05) with pDCs numbers, CD80 expression, IL-6 levels and IFN-gamma levels in these women. Estradiol 0-14 interleukin 6 Homo sapiens 207-211 18160129-0 2008 Effects of estradiol on regulation of corticotropin-releasing factor gene and interleukin-6 production via estrogen receptor type beta in hypothalamic 4B cells. Estradiol 11-20 interleukin 6 Homo sapiens 78-91 18205904-9 2008 Addition of 17beta-estradiol (10-7 M) reduced basal IL-6 production by one-third, but IL-1beta-inducible IL-6 was unaffected. Estradiol 12-28 interleukin 6 Homo sapiens 52-56 18205904-13 2008 CONCLUSION: In human colon carcinoma cells derived from well and moderately differentiated tumours, IL-6 expression is low and only marginally affected, if at all, by PGE2, 1,25-dihydroxyvitamin D3, and 17beta-estradiol. Estradiol 203-219 interleukin 6 Homo sapiens 100-104 17164077-6 2007 Serum estradiol concentration showed a significant negative correlation with serum IL-6 concentration and weak negative correlations with serum concentrations of IL-2, IL-8 and GM-CSF. Estradiol 6-15 interleukin 6 Homo sapiens 83-87 17532054-0 2007 The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells. Estradiol 14-30 interleukin 6 Homo sapiens 34-38 17532054-3 2007 In this study, we investigated the regulatory role of TLR agonists and 17beta-estradiol (E(2)) on IL-6 expression and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells (ARPE-19). Estradiol 71-87 interleukin 6 Homo sapiens 98-102 17164077-8 2007 We also found that serum IL-6 concentration during the menopausal transition was negatively correlated with serum estradiol concentration. Estradiol 114-123 interleukin 6 Homo sapiens 25-29 16284083-12 2006 Future studies should investigate 17beta-estradiol effects on IL-6 production and neutrophil infiltration within skeletal muscle during and after exercise. Estradiol 34-50 interleukin 6 Homo sapiens 62-66 17348820-5 2007 Beta-estradiol levels in women with primary infections showed significant negative correlations with cervical concentrations of IL-10, IL-1beta, and IL-6. Estradiol 0-14 interleukin 6 Homo sapiens 149-153 16914597-7 2006 Serum IL-6 levels correlated significantly (P < 0.05) with testosterone and estradiol levels (r=-0.37 and -0.42 respectively), whereas estradiol, but not testosterone, correlated with leptin/receptor ratio (r=0.59; P < 0.001). Estradiol 79-88 interleukin 6 Homo sapiens 6-10 16894332-0 2006 Effects of intranasal 17beta-estradiol administration on serum bioactive interleukin-6 and C-reactive protein levels in healthy postmenopausal women. Estradiol 22-38 interleukin 6 Homo sapiens 73-86 16894332-2 2006 The aim of our study was to investigate the effects of intranasal 17beta-estradiol (E2) on serum CRP and its most potent stimulant, interleukin-6 in healthy postmenopausal women. Estradiol 66-82 interleukin 6 Homo sapiens 132-145 16894332-2 2006 The aim of our study was to investigate the effects of intranasal 17beta-estradiol (E2) on serum CRP and its most potent stimulant, interleukin-6 in healthy postmenopausal women. Estradiol 84-86 interleukin 6 Homo sapiens 132-145 16894332-8 2006 Conversely, serum median bioactive interleukin-6 levels were significantly lower after 6 and 12 months in women taking E2 intranasally or orally and after 12 months in women taking E2 transdermally (P < 0.05). Estradiol 119-121 interleukin 6 Homo sapiens 35-48 16670485-8 2006 In primary cultures, 17beta-estradiol caused a significant decrease of IL-6 and IL-8 gene expression, but had no effect on the levels of IL-1beta, MMP-2, and MMP-9 gene expression. Estradiol 21-37 interleukin 6 Homo sapiens 71-75 16711008-0 2006 Effects of 17beta-estradiol on the expression of IL-6, IL-11 and NF-kappaB in human MG-63 osteoblast-like cell line. Estradiol 11-27 interleukin 6 Homo sapiens 49-53 16711008-1 2006 In order to characterize the effects of 17beta-estradiol (17beta-E2) on the expression of IL-6, IL-11 and NF-kappaB in the human MG-63 osteoblast-like cell line, the expression of IL-6 was detected by RT-PCR, Northern blot and Western blot. Estradiol 40-56 interleukin 6 Homo sapiens 90-94 16543969-5 2006 17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels. Estradiol 28-44 interleukin 6 Homo sapiens 119-123 15943769-4 2005 The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women. Estradiol 133-142 interleukin 6 Homo sapiens 61-79 16323060-0 2005 Vitamin D, tamoxifen and beta-estradiol modulate breast cancer cell growth and interleukin-6 and metalloproteinase-2 production in three-dimensional co-cultures of tumor cell spheroids with endothelium. Estradiol 25-39 interleukin 6 Homo sapiens 79-92 16323060-7 2005 Direct contact of tumor cell spheroids with the endothelium induced production of MMP-2 and IL-6, which was significantly inhibited in TAM/beta-estradiol balanced medium. Estradiol 139-153 interleukin 6 Homo sapiens 92-96 15528032-0 2004 Protective effects of 17beta-estradiol and trivalent chromium on interleukin-6 secretion, oxidative stress, and adhesion of monocytes: relevance to heart disease in postmenopausal women. Estradiol 22-38 interleukin 6 Homo sapiens 65-78 15983630-3 2005 In particular, 17 beta-estradiol (E2) in patients with systemic inflammatory diseases leads to an higher production of IgG and IgM in peripheral blood mononucleated cells (PBMC) and the secretion of metalloproteinases and IL-6 by synovial fibroblasts. Estradiol 15-32 interleukin 6 Homo sapiens 222-226 15528032-2 2004 We examined the hypothesis that 17beta-estradiol and trivalent chromium inhibit secretion of the pro-inflammatory cytokine interleukin (IL)-6 and oxidative stress in monocytes exposed to high glucose (HG). Estradiol 32-48 interleukin 6 Homo sapiens 123-141 15528032-5 2004 Treatment with 17beta-estradiol+Cr(3+) required a significantly lower dose of estradiol-17beta compared with 17beta-estradiol alone for IL-6 inhibition. Estradiol 15-31 interleukin 6 Homo sapiens 136-140 15528032-5 2004 Treatment with 17beta-estradiol+Cr(3+) required a significantly lower dose of estradiol-17beta compared with 17beta-estradiol alone for IL-6 inhibition. Estradiol 78-94 interleukin 6 Homo sapiens 136-140 15528032-7 2004 Thus, 17beta-estradiol+Cr(3+) inhibits oxidative stress, IL-6 secretion, and monocytic adhesion to endothelial cells, risk factors in the development of heart disease. Estradiol 6-22 interleukin 6 Homo sapiens 57-61 12468642-3 2002 Steroid-dependent secretion of IL-6 was analysed by 17beta-estradiol (10(-8) mol/l) or progesterone (10(-6) mol/l) treatment and withdrawal (n = 8). Estradiol 52-68 interleukin 6 Homo sapiens 31-35 14758567-0 2004 Estradiol stimulates vascular endothelial growth factor and interleukin-6 in human lactotroph and lactosomatotroph pituitary adenomas. Estradiol 0-9 interleukin 6 Homo sapiens 60-73 14758567-7 2004 In cell cultures obtained from tumors from which sufficient cells could be isolated, a dose-dependent effect of estradiol (1 to 100 nM) on VEGF and IL-6 production was observed. Estradiol 112-121 interleukin 6 Homo sapiens 148-152 14723336-4 2003 Interestingly, IL-1beta and IL-6 mRNA were significantly suppressed in osteoblast-like cells treated with 17beta-estradiol (E2) and PIII when compared to positive control (SDB), and this suppression was more effective at 10(-8)% than at the highest concentration of 10(-4)%. Estradiol 106-122 interleukin 6 Homo sapiens 28-32 15762036-0 2004 Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures. Estradiol 11-27 interleukin 6 Homo sapiens 92-105 12773123-3 2003 We investigated and compared the effects of 17-beta oestradiol (E(2)) and RAL on the regulation of IL-6, IL-1, RANKL and OPG in vitro in primary human osteoblastic (HOB) cells and in an immortalised clonal human bone marrow stromal cell line (HCC1) with osteoblastic characteristics. Estradiol 44-62 interleukin 6 Homo sapiens 99-103 12719374-0 2003 Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. Estradiol 28-44 interleukin 6 Homo sapiens 55-58 12719374-7 2003 The impact of 17beta-estradiol (E(2)) on the IL6-174G/C variants was investigated by reporter studies. Estradiol 14-30 interleukin 6 Homo sapiens 45-48 12417965-9 2003 Estradiol concentrations correlated positively with IL-6 levels. Estradiol 0-9 interleukin 6 Homo sapiens 52-56 11479143-4 2001 The possibility that IL-6 may also influence the basal and FSH-stimulated production of estradiol (E2) and progesterone (Prog) by GCs in vitro was also investigated. Estradiol 88-97 interleukin 6 Homo sapiens 21-25 12323121-6 2002 The IL-6 induced aromatase activity results in increased serum estradiol level. Estradiol 63-72 interleukin 6 Homo sapiens 4-8 11834456-2 2002 There is, however, controversy about the nature of the IL-6 secreted by human cells and its regulation by 17beta-oestradiol. Estradiol 106-123 interleukin 6 Homo sapiens 55-59 11834456-7 2002 The effect of 17beta-oestradiol on spontaneous IL-6 production by the PBMC of postmenopausal women was also studied in vitro and in vivo. Estradiol 14-31 interleukin 6 Homo sapiens 47-51 11834456-12 2002 Women with IL-6 gene expression in the non-stimulated PBMC had significantly lower serum levels of 17beta-oestradiol compared with those where the IL-6 gene was not expressed in the PBMC. Estradiol 99-116 interleukin 6 Homo sapiens 11-15 11834456-13 2002 Our in vitro experiments showed that 17beta-oestradiol at concentrations of 10(-9) M and 10(-10) M decreased spontaneous IL-6 production by the PBMC of postmenopausal women. Estradiol 37-54 interleukin 6 Homo sapiens 121-125 11834456-14 2002 In vivo treatment with 17beta-oestradiol transdermally also significantly decreased spontaneous IL-6 production by the PBMC of postmenopausal women after 12 months of the therapy. Estradiol 23-40 interleukin 6 Homo sapiens 96-100 11429412-4 2001 Here we show that the ER agonist 17 beta-estradiol completely abolished IL-6-inducible MM cell proliferation. Estradiol 33-50 interleukin 6 Homo sapiens 72-76 11959895-8 2002 RESULTS: Levels of IL-6 mRNA and protein increased in all cells treated with follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol, or estrone but increased only in OVCA cells treated with testosterone and 5alpha-dihydrotestosterone. Estradiol 139-155 interleukin 6 Homo sapiens 19-23 11814313-2 2001 We tested the hypothesis that IL-6 secretion by human marrow cells and a line of marrow stromal cells (KM101) is inhibited by dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and 17beta-oestradiol (E(2)). Estradiol 187-204 interleukin 6 Homo sapiens 30-34 10774110-3 2000 There were a negative correlation between follicular levels of IL-6 and either estradiol and progesterone. Estradiol 79-88 interleukin 6 Homo sapiens 63-67 11509008-5 2001 We examined the effects of physiological and supraphysiological concentrations of 17beta-estradiol (E2) and cortisol on basal and IL-1beta-induced IL-6 release in the medium. Estradiol 82-98 interleukin 6 Homo sapiens 147-151 11415991-0 2001 Differential effects of estradiol on the adrenocorticotropin responses to interleukin-6 and interleukin-1 in the monkey. Estradiol 24-33 interleukin 6 Homo sapiens 74-87 11113455-5 2000 IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) activity and STAT3-mediated gene expression were suppressed by 17beta-estradiol (E2) in breast cancer cells. Estradiol 149-165 interleukin 6 Homo sapiens 0-4 10880259-2 2000 When stable HBD-FGF-2 HeLa cell lines were transiently transfected with an interleukin 6 (IL-6) construct, the IL-6 promoter activity was downregulated by the addition of oestradiol. Estradiol 171-181 interleukin 6 Homo sapiens 75-88 10880259-2 2000 When stable HBD-FGF-2 HeLa cell lines were transiently transfected with an interleukin 6 (IL-6) construct, the IL-6 promoter activity was downregulated by the addition of oestradiol. Estradiol 171-181 interleukin 6 Homo sapiens 90-94 10880259-2 2000 When stable HBD-FGF-2 HeLa cell lines were transiently transfected with an interleukin 6 (IL-6) construct, the IL-6 promoter activity was downregulated by the addition of oestradiol. Estradiol 171-181 interleukin 6 Homo sapiens 111-115 10805226-5 2000 In premenopausal females the concentration of estradiol in plasma correlated with the release of TNF-alpha and IL-6 during the luteal phase. Estradiol 46-55 interleukin 6 Homo sapiens 111-115 10729217-7 2000 In contrast, beta-estradiol and testosterone increased LPS-induced IL-6 secretion in six of seven time points during the MC (significant for testosterone, p = .005). Estradiol 13-27 interleukin 6 Homo sapiens 67-71 11138340-1 2000 OBJECTIVE: In view of the importance of estrogen and IL-6 in the pathogenesis of rheumatoid arthritis (RA), the effects of 17 beta-estradiol (E2) on interleukin (IL)-6 production in cultured rheumatoid fibroblast-like synoviocytes were investigated. Estradiol 123-140 interleukin 6 Homo sapiens 149-167 10755407-1 2000 Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. Estradiol 87-104 interleukin 6 Homo sapiens 0-13 10755407-1 2000 Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. Estradiol 87-104 interleukin 6 Homo sapiens 15-19 10755407-1 2000 Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. Estradiol 106-108 interleukin 6 Homo sapiens 0-13 10755407-1 2000 Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. Estradiol 106-108 interleukin 6 Homo sapiens 15-19 10774110-0 2000 [Effect of intrafollicular interleukin-6 levels on the secretion of estradiol and progesterone in patients treated with in vitro fertilization and embryo transfer]. Estradiol 68-77 interleukin 6 Homo sapiens 27-40 10774110-1 2000 The objective was to evaluate the relationship between follicular fluid levels of Interleukin-6 (IL-6) and the seric concentrations of estradiol and progesterone during controlled ovarian hyper-stimulation. Estradiol 135-144 interleukin 6 Homo sapiens 82-95 10774110-1 2000 The objective was to evaluate the relationship between follicular fluid levels of Interleukin-6 (IL-6) and the seric concentrations of estradiol and progesterone during controlled ovarian hyper-stimulation. Estradiol 135-144 interleukin 6 Homo sapiens 97-101 10774110-6 2000 According to the reduction of estradiol, there may be a subtle reduction in aromatase action by effect of IL-6 and other cytokines. Estradiol 30-39 interleukin 6 Homo sapiens 106-110 9171095-2 1997 We have previously shown that the effects of TNFalphaand estradiol on the human IL-6 promoter were dependent on a region of the promoter containing a C/EBP site and a NF-kappaB site. Estradiol 57-66 interleukin 6 Homo sapiens 80-84 10424406-6 1999 Stepwise multiple linear regression analysis demonstrated that the concentration of IL-6 in breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA-S, and by a positive regression coefficient for the concentration of TNF-alpha. Estradiol 200-209 interleukin 6 Homo sapiens 84-88 9712363-5 1998 Using reverse-transcriptase polymerase chain reaction (RT-PCR) and ELISA respectively, we demonstrate further that levels of 17beta-estradiol (active metabolite of estrogen) > or = those found in serum of estrogen-sufficient women inhibit steady-state IL-6 mRNA levels as well as inhibit secretion of IL-6 into culture supernatants. Estradiol 125-141 interleukin 6 Homo sapiens 255-259 9712363-5 1998 Using reverse-transcriptase polymerase chain reaction (RT-PCR) and ELISA respectively, we demonstrate further that levels of 17beta-estradiol (active metabolite of estrogen) > or = those found in serum of estrogen-sufficient women inhibit steady-state IL-6 mRNA levels as well as inhibit secretion of IL-6 into culture supernatants. Estradiol 125-141 interleukin 6 Homo sapiens 304-308 9792467-0 1998 Effects of 17beta-estradiol and progesterone on interleukin-6 production and proliferation of human umbilical vein endothelial cells. Estradiol 11-27 interleukin 6 Homo sapiens 48-61 9792467-5 1998 17Beta-estradiol significantly inhibited basal IL-6 secretion at doses of 10(-12)-10(-6) mol/l whereas progesterone had no measurable effects. Estradiol 0-16 interleukin 6 Homo sapiens 47-51 9792467-7 1998 The results of our study suggest that 17beta-estradiol at non-proliferative doses regulates IL-6 secretion of endothelial cells and thereby modulates processes of vascular physiology. Estradiol 38-54 interleukin 6 Homo sapiens 92-96 9368513-4 1997 The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3. Estradiol 33-51 interleukin 6 Homo sapiens 138-142 10049521-2 1998 IL-6 increases the activity of the 17beta-oxidoreductase, which converts oestrone to oestradiol, a process that may contribute to the increased concentration of oestrogen around breast tumours. Estradiol 85-95 interleukin 6 Homo sapiens 0-4 8776731-3 1996 As previous reports have shown that the human IL-6 promoter is inhibited by estradiol, we investigated the mechanism of estradiol (E2)-mediated IL-6 inhibition in human cells. Estradiol 76-85 interleukin 6 Homo sapiens 46-50 9199508-0 1997 Repression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor. Estradiol 54-64 interleukin 6 Homo sapiens 14-27 9199508-3 1997 In the endometrial adenocarcinoma cell line Ishikawa, phorbol ester-induced activation of the IL-6 promoter was inhibited to basal levels by 17 beta-estradiol (E2) in a wild-type receptor-dependent fashion. Estradiol 141-158 interleukin 6 Homo sapiens 94-98 9169347-8 1997 Pretreatment of cells with 17 beta-estradiol (17 beta-E2) antagonized IL-1-stimulated IL-6 production. Estradiol 27-44 interleukin 6 Homo sapiens 86-90 9093798-4 1997 A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. Estradiol 56-65 interleukin 6 Homo sapiens 41-45 17265626-5 1997 In postmenopausal group, there was a negative significant correlation between estradiol level and both IL-6 and osteocalcin levels. Estradiol 78-87 interleukin 6 Homo sapiens 103-107 17265626-8 1997 When correlating the parameters of all the 46 patients, there was a highly negative significant correlation between estradiol level and IL-6 and a negative significant correlation between estradiol level and osteocalcin, while there was a positive significant correlation between osteocalcin and IL-6. Estradiol 116-125 interleukin 6 Homo sapiens 136-140 8776731-3 1996 As previous reports have shown that the human IL-6 promoter is inhibited by estradiol, we investigated the mechanism of estradiol (E2)-mediated IL-6 inhibition in human cells. Estradiol 120-129 interleukin 6 Homo sapiens 144-148 21153120-0 1995 Effect of 17beta-oestradiol on expression of IL-2, IL-6 and IFN-gamma mRNA in human tonsillar cells. Estradiol 10-27 interleukin 6 Homo sapiens 51-55 8822343-8 1996 As assessed by Northern analysis, treatment (n = 3 experiments) with 0.01-10 nM of 17 beta-estradiol decreased steady-state levels of IL-6 mRNA in a dose-dependent manner. Estradiol 83-100 interleukin 6 Homo sapiens 134-138 23448998-5 2013 Estradiol correlated positively with interleukin-6 (IL-6), weight, body mass index (BMI), insulin, homocysteine, and homeostasis model assessment of insulin resistance (HOMA-IR). Estradiol 0-9 interleukin 6 Homo sapiens 37-50 7490545-8 1995 The abilities of oestradiol or tamoxifen to potentiate or inhibit the IL-6 stimulation of oestrogen synthesis in breast cancer cells may result from their effects on IL-6sR release. Estradiol 17-27 interleukin 6 Homo sapiens 70-74 7558422-7 1995 The inhibitory effect of IL-6 on the secretion of these two biochemical markers was additive to that of 17 beta-estradiol. Estradiol 104-121 interleukin 6 Homo sapiens 25-29 1536986-2 1992 We have investigated the effects of oestradiol on the release of two cytokines, IL-6 and TNF, known to be produced by normal human osteoblast-like cells. Estradiol 36-46 interleukin 6 Homo sapiens 80-92 1536986-3 1992 The effect of oestradiol on basal and stimulated IL-6 and TNF release was investigated. Estradiol 14-24 interleukin 6 Homo sapiens 49-53 2104896-9 1990 Analysis of hormonal influences on chondrocyte IL-6 production showed that testosterone and estradiol synergized with IL-1 in the induction of IL-6. Estradiol 92-101 interleukin 6 Homo sapiens 47-51 2104896-9 1990 Analysis of hormonal influences on chondrocyte IL-6 production showed that testosterone and estradiol synergized with IL-1 in the induction of IL-6. Estradiol 92-101 interleukin 6 Homo sapiens 143-147 7590603-8 1995 In the perfusion experiment, 100 ng/ml of IL-6 suppressed LH (100ng/ml)-induced estradiol (E2) secretion but did not influence progesterone (P4) secretion, while IL-2 had no effect on steroid secretion. Estradiol 80-89 interleukin 6 Homo sapiens 42-46 8132780-0 1994 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. Estradiol 3-17 interleukin 6 Homo sapiens 47-60 8132780-1 1994 We previously reported that 17 beta-estradiol inhibits cytokine-stimulated bioassayable IL-6 and the steady-state level of IL-6 mRNA. Estradiol 28-45 interleukin 6 Homo sapiens 88-92 8132780-1 1994 We previously reported that 17 beta-estradiol inhibits cytokine-stimulated bioassayable IL-6 and the steady-state level of IL-6 mRNA. Estradiol 28-45 interleukin 6 Homo sapiens 123-127 8132780-3 1994 17 beta-estradiol (10(-8) M) completely suppressed stimulated CAT expression in HeLa cells cotransfected with IL-6/CAT constructs and a human estrogen receptor (hER) expression plasmid; but had no effect on reporter expression in HeLa cells not transfected with hER. Estradiol 3-17 interleukin 6 Homo sapiens 110-114 8132780-7 1994 These data suggest that 17 beta-estradiol inhibits the stimulated expression of the human IL-6 gene through an estrogen receptor mediated indirect effect on the transcriptional activity of the proximal 225-bp sequence of the promoter. Estradiol 27-41 interleukin 6 Homo sapiens 90-94 8240983-1 1993 Previous studies have revealed that human breast fibroblasts secrete the cytokine, interleukin-6 (IL-6) which stimulates the ability of MCF-7 human breast carcinoma cells to convert estrone (E1) to the biologically more active 17 beta-estradiol (E2). Estradiol 230-244 interleukin 6 Homo sapiens 83-96 8240983-1 1993 Previous studies have revealed that human breast fibroblasts secrete the cytokine, interleukin-6 (IL-6) which stimulates the ability of MCF-7 human breast carcinoma cells to convert estrone (E1) to the biologically more active 17 beta-estradiol (E2). Estradiol 230-244 interleukin 6 Homo sapiens 98-102 8219478-7 1993 IL-6 was increased by GH and IGF-I, and lowered by 1,25(OH)2D3 and supraphysiological doses of 17 beta-oestradiol, while PTH(1-34) had no effects. Estradiol 95-113 interleukin 6 Homo sapiens 0-4 8393337-1 1993 It has been demonstrated that reductive 17 beta-hydroxysteroid dehydrogenase activity (17-HSD) in the human breast cancer cell line MCF-7 can be stimulated by 17 beta-estradiol (E2), progesterone (P) and interleukin-6 (IL-6). Estradiol 159-176 interleukin 6 Homo sapiens 204-217 8393337-1 1993 It has been demonstrated that reductive 17 beta-hydroxysteroid dehydrogenase activity (17-HSD) in the human breast cancer cell line MCF-7 can be stimulated by 17 beta-estradiol (E2), progesterone (P) and interleukin-6 (IL-6). Estradiol 159-176 interleukin 6 Homo sapiens 219-223 8453620-5 1993 IL-1 and IL-6 also antagonized estradiol (10(-9) M) stimulated growth. Estradiol 31-40 interleukin 6 Homo sapiens 9-13 8453620-13 1993 These findings indicate that IL-1 and IL-6 act additively to inhibit growth in the absence or presence of estradiol and modulate the estrogen receptor and progesterone receptor content of these cells. Estradiol 106-115 interleukin 6 Homo sapiens 38-42 8508557-4 1993 In studies of cells from normal male donors, 17-beta-estradiol at pharmacological concentrations (> or = 10(-6) M) enhanced IL-1 and IL-6 secretion as well as the production of cell-associated IL-1. Estradiol 45-62 interleukin 6 Homo sapiens 136-140 8508557-8 1993 It is suggested that 17-beta-estradiol may promote IL-1 and IL-6 production and release, while gestation hormone, progesterone, and testosterone may inhibit IL-1 release in vivo. Estradiol 21-38 interleukin 6 Homo sapiens 60-64 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. Estradiol 217-234 interleukin 6 Homo sapiens 164-168 23448998-5 2013 Estradiol correlated positively with interleukin-6 (IL-6), weight, body mass index (BMI), insulin, homocysteine, and homeostasis model assessment of insulin resistance (HOMA-IR). Estradiol 0-9 interleukin 6 Homo sapiens 52-56 34733276-6 2021 Furthermore, we found significantly increased plasma levels of IL-6, IL-12, IL-17, IL-18, stem cell factor (SCF), and IL-21/IL-23 in SLE patients compared to healthy controls, and those levels positively correlated with the plasma levels of 17beta-estradiol. Estradiol 241-257 interleukin 6 Homo sapiens 63-67 34733276-8 2021 In vitro treatment of PBMCs from either SLE patients or healthy controls with 17beta-estradiol at physiological concentration (~50 pg/ml) also significantly increased secretion of many pro-inflammatory cytokines and chemokines (IL-6, IL-12, IL-17, IL-8, IFN-gamma; MIP1alpha, and MIP1beta) in both groups. Estradiol 78-94 interleukin 6 Homo sapiens 228-232 2651521-5 1989 This secretion was strongly inhibited by estradiol-17 beta at concentrations as low as 10(-9) M. Multiple species of stromal cell IFN-beta 2/IL-6 in the size range 23 to 30 kDa were detected using immunoprecipitation or immunoblotting procedures. Estradiol 41-50 interleukin 6 Homo sapiens 130-140 34589801-11 2021 Estradiol during pregnancy was positively correlated with IL-6 levels both during pregnancy (r p = .656, p = .008) and postpartum (r = 0.648, p = .023). Estradiol 0-9 interleukin 6 Homo sapiens 58-62 35406728-5 2022 Additionally, the sex-biased phenotype of certain cancers (e.g., hepatocellular carcinoma (HCC) which is 3-5-fold more common in men) was related to the inhibition of macrophage-derived IL-6 production by estradiol-17beta (E2). Estradiol 205-221 interleukin 6 Homo sapiens 186-190 35406728-5 2022 Additionally, the sex-biased phenotype of certain cancers (e.g., hepatocellular carcinoma (HCC) which is 3-5-fold more common in men) was related to the inhibition of macrophage-derived IL-6 production by estradiol-17beta (E2). Estradiol 223-225 interleukin 6 Homo sapiens 186-190 2651521-5 1989 This secretion was strongly inhibited by estradiol-17 beta at concentrations as low as 10(-9) M. Multiple species of stromal cell IFN-beta 2/IL-6 in the size range 23 to 30 kDa were detected using immunoprecipitation or immunoblotting procedures. Estradiol 41-50 interleukin 6 Homo sapiens 141-145 7002285-4 1980 17 beta-estradiol had no effect on the extranuclear protease activities, or resistance to CDSC, but it increased DNA and protein synthesis in HSF and HNMEC cell lines. Estradiol 3-17 interleukin 6 Homo sapiens 142-145 32962815-10 2020 These findings suggest that E2 differentially alters iron metabolism in monocytes in an IL-6 dependent manner. Estradiol 28-30 interleukin 6 Homo sapiens 88-92 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Estradiol 11-13 interleukin 6 Homo sapiens 26-30 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Estradiol 11-13 interleukin 6 Homo sapiens 156-160 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Estradiol 94-96 interleukin 6 Homo sapiens 26-30 32697835-6 2021 E2 levels were negatively correlated with IL-2R, IL-6, IL-8 and TNFalpha in luteal phase (Pearson Correlation=-0.592, -0.558, -0.545, -0.623; p=0.033, 0.048, 0.054, 0.023), and with C3 in follicular phase (Pearson Correlation=-0.651; p=0.030). Estradiol 0-2 interleukin 6 Homo sapiens 49-53 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Estradiol 94-96 interleukin 6 Homo sapiens 156-160 32141941-6 2020 RESULTS: Pretreatment with 10 M DHT or 17-beta-estradiol inhibited the high osmolarity-induced expression of TNF-alpha, IL-8, and IL-6. Estradiol 39-56 interleukin 6 Homo sapiens 130-134