PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29438359-0 2018 Effects of 17beta-Estradiol on Mitophagy in the Murine MC3T3-E1 Osteoblast Cell Line is Mediated via G Protein-Coupled Estrogen Receptor and the ERK1/2 Signaling Pathway. Estradiol 11-27 mitogen-activated protein kinase 3 Mus musculus 145-151 32879215-3 2020 Activity of mitogen-activated protein kinase (MAPK) was increased in the tumor cells treated with E2, and enhanced secretion of LPL was suppressed by MAPK kinase 1/2 inhibitor, PD98059, extracellular signal-regulated kinase (ERK) 1/2 inhibitor, FR180204, p38 MAPK inhibitor, SB202190, and phosphatidyl inositol 3-kinase (PI3K) inhibitor, LY294002. Estradiol 98-100 mitogen-activated protein kinase 3 Mus musculus 186-233 29438359-10 2018 CONCLUSIONS In murine osteoblasts cultured in vitro, treatment with 17beta-estradiol resulted in the expression of GPR30 and enhanced mitophagy through the GPR30 and ERK1/2 signaling pathway. Estradiol 68-84 mitogen-activated protein kinase 3 Mus musculus 166-172 22096576-9 2011 Estradiol-induced phosphorylation of ERK1/2 and p38 MAPK was examined by Western blot. Estradiol 0-9 mitogen-activated protein kinase 3 Mus musculus 37-43 25733860-0 2015 Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17beta is mediated by a PKC-ERK1/2-mTOR signaling pathway. Estradiol 69-85 mitogen-activated protein kinase 3 Mus musculus 107-113 25338647-5 2015 Using pharmacological inhibitors we showed that the effect of estradiol was mediated by the MAPK/ERK 1/2 pathway, but that inhibition of this pathway did not affect tamoxifen. Estradiol 62-71 mitogen-activated protein kinase 3 Mus musculus 97-104 22117068-6 2012 Akt and ERK1/2 activation by 17beta-estradiol required PKG II, and cGMP mimicked the effects of estradiol on Akt and ERK, including induction of ERK nuclear translocation. Estradiol 29-45 mitogen-activated protein kinase 3 Mus musculus 8-14 22117068-6 2012 Akt and ERK1/2 activation by 17beta-estradiol required PKG II, and cGMP mimicked the effects of estradiol on Akt and ERK, including induction of ERK nuclear translocation. Estradiol 36-45 mitogen-activated protein kinase 3 Mus musculus 8-14 20971161-8 2011 Administration of slow-release pellets containing 17beta-estradiol at week 5 post OVX reversed both the development of the hyperalgesia and the enhanced activation of ERK 1/2, suggesting that this activation, like the hyperalgesic state, was estrogen-dependent. Estradiol 50-66 mitogen-activated protein kinase 3 Mus musculus 167-174 24974217-11 2014 beta-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERalpha-neutralizing antibody or ERK1/2 inhibitor. Estradiol 0-14 mitogen-activated protein kinase 3 Mus musculus 128-134 22096576-13 2011 Estradiol enhanced ERK1/2 phosphorylation. Estradiol 0-9 mitogen-activated protein kinase 3 Mus musculus 19-25 18622696-7 2009 The presence of membrane estrogen receptors in both cell types was suggested by the achievement of non-genomic responses to short treatments with estradiol, leading to the phosphorylation of ERK1/2. Estradiol 146-155 mitogen-activated protein kinase 3 Mus musculus 191-197 19450605-4 2009 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression, attenuated gp91(phox)-NADPH oxidase expression and activity, decreased phosphorylation of ERK1/2/p38 MAPK and inhibited cardiac TNF-alpha expression induced by LPS, suggesting an important role of Rac1 and estrogen in LPS-stimulated TNF-alpha expression in the heart. Estradiol 52-68 mitogen-activated protein kinase 3 Mus musculus 191-197 18694845-6 2009 LY 294002 (a PI3K inhibitor) or PD 98059 (an ERK1/2 inhibitor) prevented E(2)-induced increase in caveolin-1 expression and the accompanying [(3)H]-thymidine incorporation. Estradiol 73-77 mitogen-activated protein kinase 3 Mus musculus 45-51 17197172-4 2007 In this work, using the same muscle cell line, we demonstrate that 1alpha,25(OH)(2)D(3) or 17beta-estradiol phosphorylate and activate ERK1/2 and p38 MAPK after longer treatment intervals, maximal effects seen at 90 and 30 min (ERK1/2) and at 60 and 15 min (p38 MAPK) for these hormones, respectively. Estradiol 91-107 mitogen-activated protein kinase 3 Mus musculus 135-141 15379891-3 2004 In a septal murine cell line (SN56), we observed that short exposures to either 17beta-oestradiol (E2) or membrane impermeant E2 bound to horseradish peroxidase (E-HRP) induced a biphasic stimulation of extracellular-signal regulated protein kinase (ERK1/2) phosphorylation, with peak inductions detected around 4-8 min in the early phase and a second maximum around 8 h after treatment. Estradiol 80-97 mitogen-activated protein kinase 3 Mus musculus 250-256 17197172-4 2007 In this work, using the same muscle cell line, we demonstrate that 1alpha,25(OH)(2)D(3) or 17beta-estradiol phosphorylate and activate ERK1/2 and p38 MAPK after longer treatment intervals, maximal effects seen at 90 and 30 min (ERK1/2) and at 60 and 15 min (p38 MAPK) for these hormones, respectively. Estradiol 91-107 mitogen-activated protein kinase 3 Mus musculus 228-234 17197172-6 2007 1alpha,25(OH)(2)D(3) and 17beta-estradiol also induced the phosphorylation of CREB and Elk-1 transcription factors in an ERK1/2-dependent manner. Estradiol 25-41 mitogen-activated protein kinase 3 Mus musculus 121-127 17197172-9 2007 The action of 17beta-estradiol on c-fos levels was also dependent on ERK1/2. Estradiol 14-30 mitogen-activated protein kinase 3 Mus musculus 69-75 11748628-0 2002 Estradiol-induced phosphorylation of ERK1/2 in explants of the mouse cerebral cortex: the roles of heat shock protein 90 (Hsp90) and MEK2. Estradiol 0-9 mitogen-activated protein kinase 3 Mus musculus 37-43 11748628-1 2002 Confocal laser scanning microscopy was used to identify the cells within organotypic slice cultures of the developing mouse cerebral cortex that respond to estradiol treatment by phosphorylation of ERK1 and ERK2. Estradiol 156-165 mitogen-activated protein kinase 3 Mus musculus 198-202