PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35103351-0	2022	Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells.	Estradiol	0-9	transmembrane serine protease 2	Homo sapiens	27-34	
35103351-6	2022	Treatment of A549 human lung epithelial cells with 17-beta-estradiol reduced the cellular mRNA levels of ACE2 and TMPRSS2 mRNA, while not affecting FURIN expression.	Estradiol	51-68	transmembrane serine protease 2	Homo sapiens	114-121	
35103351-8	2022	Studies into the molecular pathways by which 17-beta-estradiol reduces ACE2 and TMPRSS2 mRNA expression in lung epithelial cells are needed for assessing its potential protective value against severe Covid-19.	Estradiol	45-62	transmembrane serine protease 2	Homo sapiens	80-87	
33606519-7	2021	This study, for the first time, reports the molecules like cyclosporine, calcitriol, and estradiol as candidate drugs with the binding ability to the host proteases, TMPRSS2, and cathepsin B/L.	Estradiol	89-98	transmembrane serine protease 2	Homo sapiens	166-173