PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12020745-0 2002 Effects of testosterone and 17-beta-estradiol on TNF-alpha-induced E-selectin and VCAM-1 expression in endothelial cells. Estradiol 28-45 vascular cell adhesion molecule 1 Homo sapiens 82-88 25627546-0 2015 Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARalpha Activation. Estradiol 0-9 vascular cell adhesion molecule 1 Homo sapiens 50-56 12020745-7 2002 Flow cytometric analysis showed that preincubation with androgen receptor antagonist cyproterone and estrogen receptor antagonist tamoxifen completely abrogated the upregulating effects of testosterone and 17-beta-estradiol on TNF-alpha-induced E-selectin and VCAM-1 expression, respectively. Estradiol 206-223 vascular cell adhesion molecule 1 Homo sapiens 260-266 12020745-9 2002 The data indicate that both testosterone and 17-beta-estradiol increase TNF-alpha-induced E-selectin and VCAM-1 expression in endothelial cells via a receptor-mediated system, and expression of TNF receptors are not changed in these actions. Estradiol 45-62 vascular cell adhesion molecule 1 Homo sapiens 105-111 12547825-1 2003 17-beta estradiol (17-beta E(2)) attenuates the expression of vascular cell adhesion molecule 1 (VCAM-1) in vivo at physiological levels (pg/ml), whereas supraphysiological concentrations of 17-beta E(2) (ng/ml) are required in vitro. Estradiol 0-17 vascular cell adhesion molecule 1 Homo sapiens 62-95 12547825-1 2003 17-beta estradiol (17-beta E(2)) attenuates the expression of vascular cell adhesion molecule 1 (VCAM-1) in vivo at physiological levels (pg/ml), whereas supraphysiological concentrations of 17-beta E(2) (ng/ml) are required in vitro. Estradiol 0-17 vascular cell adhesion molecule 1 Homo sapiens 97-103 12020745-2 2002 This study investigated the effects of testosterone and 17-beta-estradiol on tumor necrosis factor-alpha (TNF-alpha)-induced endothelial expression of E-selectin and vascular cell adhesion molecule-1 (VCAM-1) and the potential roles of hormone receptors involved in these actions. Estradiol 56-73 vascular cell adhesion molecule 1 Homo sapiens 166-199 12020745-4 2002 As shown by Western blot analysis, co-administration with testosterone or 17-beta-estradiol increased the expression of E-selectin and VCAM-1 induced by TNF-alpha at 6 h and 3 h, respectively. Estradiol 74-91 vascular cell adhesion molecule 1 Homo sapiens 135-141 12020745-5 2002 Similarly, RT-PCR analysis revealed a significant increase in the amount of mRNA for E-selectin and VCAM-1 after co-administration with testosterone or 17-beta-estradiol in TNF-alpha-stimulated HUVEC. Estradiol 152-169 vascular cell adhesion molecule 1 Homo sapiens 100-106 10022460-2 1999 17Beta-estradiol is known to inhibit endothelial vascular cell adhesion molecule (VCAM)-1 expression. Estradiol 0-16 vascular cell adhesion molecule 1 Homo sapiens 49-89 12087872-5 2002 The results showed that although testosterone or 17 beta-estradiol did not affect the expression of these adhesion molecules in unstimulated HUVEC, both of them transiently increased the expression of E-selectin and VCAM-1 in TNF-alpha stimulated HUVEC. Estradiol 49-66 vascular cell adhesion molecule 1 Homo sapiens 216-222 12087872-7 2002 It is concluded that both testosterone and 17 beta-estradiol increase TNF-alpha-induced expression of E-selectin and VCAM-1 in endothelial cells and these facts might indicate a mechanism by which gonadal hormones can indirectly enhance immune responses. Estradiol 43-60 vascular cell adhesion molecule 1 Homo sapiens 117-123 11904449-2 2002 Estradiol inhibits vascular cell adhesion molecule-1 (VCAM-1) expression, and expression of VCAM-1 is one of the early events in atherogenesis. Estradiol 0-9 vascular cell adhesion molecule 1 Homo sapiens 19-52 11904449-2 2002 Estradiol inhibits vascular cell adhesion molecule-1 (VCAM-1) expression, and expression of VCAM-1 is one of the early events in atherogenesis. Estradiol 0-9 vascular cell adhesion molecule 1 Homo sapiens 54-60 11904449-9 2002 Estradiol also attenuated VCAM-1 mRNA expression, but this action was not abolished in the presence of anastrozole, indicating that anastrozole itself did not modulate VCAM-1 mRNA expression. Estradiol 0-9 vascular cell adhesion molecule 1 Homo sapiens 26-32 11904449-12 2002 In conclusion, testosterone inhibited VCAM-1 mRNA and protein expression in HUVEC by its conversion to estradiol via the enzyme aromatase present in the endothelial cells. Estradiol 103-112 vascular cell adhesion molecule 1 Homo sapiens 38-44 10022460-4 1999 We here demonstrate a concentration-dependent inhibitory action on VCAM-1 protein expression both for 17beta-estradiol and LY117018. Estradiol 102-118 vascular cell adhesion molecule 1 Homo sapiens 67-73 10022460-8 1999 Both 17beta-estradiol and LY117018 inhibited HSVEC VCAM-1 expression at the mRNA level, while tamoxifen was ineffective. Estradiol 5-21 vascular cell adhesion molecule 1 Homo sapiens 51-57 7506711-0 1994 Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. Estradiol 0-9 vascular cell adhesion molecule 1 Homo sapiens 203-241 9052593-5 1997 RESULTS: We found that 17 beta-estradiol augmented the TNF-alpha-induced expression of endothelial leukocyte adhesion molecule-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 by 107, 9, and 39%, respectively. Estradiol 23-40 vascular cell adhesion molecule 1 Homo sapiens 169-202 9699892-5 1998 Expression of VCAM-1 in endothelial cells after exposure to tumour necrosis factor-alpha (TNF-alpha) or interleukin 1beta (IL-1beta) was quantified by ELISA and shown to be partially inhibited by 17beta-estradiol (40-60% inhibition) or by S-nitroso-L-glutathione, a nitric oxide donor (20-25%). Estradiol 196-212 vascular cell adhesion molecule 1 Homo sapiens 14-20 8548848-0 1996 Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by beta-estradiol, progesterone, and dexamethasone. Estradiol 79-93 vascular cell adhesion molecule 1 Homo sapiens 69-75 7506711-6 1994 The estradiol-induced increase in leukocyte binding to human umbilical vein endothelial cells was partially blocked by antibodies to the adhesion molecules E-selectin, intercellular adhesion molecule type 1 (ICAM-1), and vascular cell adhesion molecule type 1 (VCAM-1). Estradiol 4-13 vascular cell adhesion molecule 1 Homo sapiens 221-259 7506711-6 1994 The estradiol-induced increase in leukocyte binding to human umbilical vein endothelial cells was partially blocked by antibodies to the adhesion molecules E-selectin, intercellular adhesion molecule type 1 (ICAM-1), and vascular cell adhesion molecule type 1 (VCAM-1). Estradiol 4-13 vascular cell adhesion molecule 1 Homo sapiens 261-267 7506711-8 1994 Northern blot analysis demonstrated a transient increase in TNF-induced expression of mRNA for E-selectin, ICAM-1, and VCAM-1 in endothelial cells treated with estradiol. Estradiol 160-169 vascular cell adhesion molecule 1 Homo sapiens 119-125 7511198-4 1994 Preincubation with estradiol-17 beta (250 or 500 pg/ml) suppressed the induction of VCAM-1 mRNA expression by interleukin-1 beta. Estradiol 19-36 vascular cell adhesion molecule 1 Homo sapiens 84-90 7511198-5 1994 VCAM-1 staining with a monoclonal antibody decreased when cells were incubated with estradiol-17 beta at 250 and 500 pg/ml, while staining was detectable when cells were treated with interleukin-1 beta at 0.5 micrograms/ml. Estradiol 84-101 vascular cell adhesion molecule 1 Homo sapiens 0-6