PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7779754-1 1995 17 beta-estradiol induces the synthesis of massive amounts of the hepatic mRNA encoding the Xenopus laevis egg yolk precursor protein, vitellogenin. Estradiol 3-17 a1-a Xenopus laevis 135-147 7779754-4 1995 We recently reported that Xenopus liver contains a protein, which is induced by 17 beta-estradiol and binds with a high degree of specificity to a binding site in a segment of the 3"-untranslated region (3"-UTR) of vitellogenin mRNA implicated in 17 beta-estradiol stabilization of vitellogenin mRNA. Estradiol 80-97 a1-a Xenopus laevis 215-227 7779754-4 1995 We recently reported that Xenopus liver contains a protein, which is induced by 17 beta-estradiol and binds with a high degree of specificity to a binding site in a segment of the 3"-untranslated region (3"-UTR) of vitellogenin mRNA implicated in 17 beta-estradiol stabilization of vitellogenin mRNA. Estradiol 80-97 a1-a Xenopus laevis 282-294 7779754-4 1995 We recently reported that Xenopus liver contains a protein, which is induced by 17 beta-estradiol and binds with a high degree of specificity to a binding site in a segment of the 3"-untranslated region (3"-UTR) of vitellogenin mRNA implicated in 17 beta-estradiol stabilization of vitellogenin mRNA. Estradiol 247-264 a1-a Xenopus laevis 215-227 7779754-4 1995 We recently reported that Xenopus liver contains a protein, which is induced by 17 beta-estradiol and binds with a high degree of specificity to a binding site in a segment of the 3"-untranslated region (3"-UTR) of vitellogenin mRNA implicated in 17 beta-estradiol stabilization of vitellogenin mRNA. Estradiol 247-264 a1-a Xenopus laevis 282-294 3582729-1 1987 We have previously demonstrated that injection of adult male frogs with estradiol-17 beta causes extensive proliferation of liver parenchymal cells together with the induction of vitellogenin (R. J. Spolski, W. Schneider, and L. J. Wangh (1985) Dev. Estradiol 72-89 a1-a Xenopus laevis 179-191 7556019-8 1995 In both species, estradiol and DES treatments induced the most vitellogenin, whereas DDT treatments induced smaller amounts of vitellogenin in a dose-dependent fashion. Estradiol 17-26 a1-a Xenopus laevis 63-75 7821717-1 1994 Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993). Estradiol 112-121 a1-a Xenopus laevis 137-149 7821717-1 1994 Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993). Estradiol 112-121 a1-a Xenopus laevis 151-154 8186148-4 1994 Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis. Estradiol 110-119 a1-a Xenopus laevis 82-94 8186148-4 1994 Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis. Estradiol 110-119 a1-a Xenopus laevis 96-99 3582267-3 1986 Using this procedure, 934 mg vitellogenin was purified from 49 ml of estradiol treated female Xenopus plasma (about 19 mg/ml). Estradiol 69-78 a1-a Xenopus laevis 29-41 3030694-2 1987 However, administration of estradiol results in a rapid 2- to 5-fold increase in cellular estrogen receptor content concurrent with the de novo transcriptional activation of the genes for the yolk protein precursor vitellogenin. Estradiol 27-36 a1-a Xenopus laevis 215-227 3733641-1 1986 We have recently shown that extensive proliferation of liver parenchymal cells takes place in adult male Xenopus frogs in response to estradiol-17 beta, which also induces synthesis and secretion of vitellogenin, the precursor of yolk proteins. Estradiol 134-151 a1-a Xenopus laevis 199-211 3733641-5 1986 Estradiol-17 beta causes a dose-dependent increase in the number of cells synthesizing DNA, as well as inducing synthesis of vitellogenin. Estradiol 0-17 a1-a Xenopus laevis 125-137 3582267-9 1986 Vitellogenin content was increased gradually during the first 6 days after injection of estradiol in female and the elevated level of vitellogenin dropped afterward. Estradiol 88-97 a1-a Xenopus laevis 0-12 4092682-3 1985 In the absence of heparin, a liver S-100 extract from female or male Xenopus treated with estradiol, but not from hormonally untreated males, induced the de novo transcription of vitellogenin genes in nuclei from hormonally naive male hepatocytes. Estradiol 90-99 a1-a Xenopus laevis 179-191 3702426-2 1986 After administration of oestradiol-17 beta there is a dramatic increase in the number of copies of vitellogenin m-RNA in the liver of male oviparous animals, like Xenopus and chicken. Estradiol 24-42 a1-a Xenopus laevis 99-111 3944139-2 1986 Vitellogenin transcription was detected 2 h after a single dose of estradiol and reached a maximum on day 4. Estradiol 67-76 a1-a Xenopus laevis 0-12 6354735-3 1983 Dexamethasone induced or stimulated the synthesis of many proteins (though limited in number), whereas estradiol induced or stimulated relatively few proteins, including the yolk precursor protein vitellogenin. Estradiol 103-112 a1-a Xenopus laevis 197-209 6592586-1 1984 Injection of extracts from Xenopus liver nuclei that are enriched 2000 times in estradiol receptor into Xenopus oocytes induces transcription of the silent vitellogenin locus, which is activated in liver by estradiol, but not of the albumin locus, which is active in liver but suppressed by high levels of estradiol. Estradiol 80-89 a1-a Xenopus laevis 156-168 6592586-1 1984 Injection of extracts from Xenopus liver nuclei that are enriched 2000 times in estradiol receptor into Xenopus oocytes induces transcription of the silent vitellogenin locus, which is activated in liver by estradiol, but not of the albumin locus, which is active in liver but suppressed by high levels of estradiol. Estradiol 207-216 a1-a Xenopus laevis 156-168 383554-0 1979 Parenchymal cells purified from Xenopus liver and maintained in primary culture synthesize vitellogenin in response to estradiol-17 beta and serum albumin in response to dexamethasone. Estradiol 119-136 a1-a Xenopus laevis 91-103 6284130-0 1982 Differential sensitization to deoxyribonuclease I of Xenopus vitellogenin and albumin genes during primary and secondary induction of vitellogenesis by oestradiol. Estradiol 152-162 a1-a Xenopus laevis 61-73 6110664-1 1981 Administration of estradiol-17 beta to male Xenopus laevis evokes the proliferation of the endoplasmic reticulum and the Golgi apparatus and the synthesis and secretion by the liver of massive amounts of the egg yolk precursor phospholipoglycoprotein, vitellogenin. Estradiol 18-35 a1-a Xenopus laevis 252-264 6510549-5 1984 Naive male cells on primary stimulation with estradiol synthesized vitellogenin mRNA at an average rate of approximately 150 moles/cell/h compared to 1200 moles/cell/h for cells previously exposed to estrogen, thus bearing a close correlation with receptor number. Estradiol 45-54 a1-a Xenopus laevis 67-79 6862098-2 1983 Vitellogenin mRNA accumulated for only 12 h after a single addition of 10(-6) M estradiol to male hepatocyte cultures; mestranol, but not 17 alpha-ethinylestradiol or diethylstilbestrol, was more potent than the natural hormone. Estradiol 80-89 a1-a Xenopus laevis 0-12 6862098-3 1983 The level and rate of accumulation of vitellogenin mRNA were 5-15 times higher in female than in male hepatocytes, mestranol and estradiol being more potent than 17 alpha-ethinylestradiol and diethylstilbestrol. Estradiol 129-138 a1-a Xenopus laevis 38-50 6862098-6 1983 The addition of fresh estradiol every 4 h to male hepatocyte cultures to compensate for its rapid metabolism resulted in a continuous and sustained accumulation of vitellogenin mRNA at rates comparable to those attained in vivo. Estradiol 22-31 a1-a Xenopus laevis 164-176 6687495-1 1983 In male Xenopus, primary estradiol administration results in noncoordinate activation in the liver of the A and B groups of vitellogenin genes, both as judged by transcription and DNase I sensitivity in isolated nuclei, B group genes being activated preferentially in the first 20 hr. Estradiol 25-34 a1-a Xenopus laevis 124-136 6687495-4 1983 A non-coordinate activation of the A and B groups of vitellogenin genes is however re-established in response to a second administration of estradiol 8 months after primary stimulation of male Xenopus. Estradiol 140-149 a1-a Xenopus laevis 53-65 6825700-5 1983 However, hepatocytes from male Xenopus that had received a single injection of estradiol 5 weeks before the cells were prepared, now exhibited identical rates and extent of accumulation of A and B groups of vitellogenin mRNAs to those observed in female cells. Estradiol 79-88 a1-a Xenopus laevis 207-219 6641722-2 1983 The rate at which receptor binds estradiol explains the kinetics of the induction of vitellogenin synthesis by estradiol, and the dissociation constant (0.5 X 10(-9) M) explains the concentration dependence of the response, which has a threshold of 10(-9) M estradiol, when 67% of the receptor is bound to estradiol. Estradiol 33-42 a1-a Xenopus laevis 85-97 6641722-2 1983 The rate at which receptor binds estradiol explains the kinetics of the induction of vitellogenin synthesis by estradiol, and the dissociation constant (0.5 X 10(-9) M) explains the concentration dependence of the response, which has a threshold of 10(-9) M estradiol, when 67% of the receptor is bound to estradiol. Estradiol 111-120 a1-a Xenopus laevis 85-97 6641722-2 1983 The rate at which receptor binds estradiol explains the kinetics of the induction of vitellogenin synthesis by estradiol, and the dissociation constant (0.5 X 10(-9) M) explains the concentration dependence of the response, which has a threshold of 10(-9) M estradiol, when 67% of the receptor is bound to estradiol. Estradiol 111-120 a1-a Xenopus laevis 85-97 6641722-2 1983 The rate at which receptor binds estradiol explains the kinetics of the induction of vitellogenin synthesis by estradiol, and the dissociation constant (0.5 X 10(-9) M) explains the concentration dependence of the response, which has a threshold of 10(-9) M estradiol, when 67% of the receptor is bound to estradiol. Estradiol 111-120 a1-a Xenopus laevis 85-97 6896404-1 1982 Administration of estradiol 17 beta [estra-1,3,5(10)-triene-3,17-beta-diol] to male Xenopus laevis induces the massive synthesis by the liver of the egg yolk precursor phospholipoglycoprotein, vitellogenin, and its cognate mRNAs. Estradiol 18-35 a1-a Xenopus laevis 193-205 6896404-1 1982 Administration of estradiol 17 beta [estra-1,3,5(10)-triene-3,17-beta-diol] to male Xenopus laevis induces the massive synthesis by the liver of the egg yolk precursor phospholipoglycoprotein, vitellogenin, and its cognate mRNAs. Estradiol 37-74 a1-a Xenopus laevis 193-205 7440543-1 1980 The levels of cytoplasmic and nuclear estrogen receptor have been determined in livers of male Xenopus laevis stimulated by estradiol-17 beta to synthesize vitellogenin mRNA. Estradiol 124-141 a1-a Xenopus laevis 156-168 7440543-4 1980 Administration of estradiol-17 beta, which induces massive synthesis and accumulation of vitellogenin mRNA, induces the estrogen receptor as well. Estradiol 18-35 a1-a Xenopus laevis 89-101 729959-1 1978 Oestradiol induces vitellogenin synthesis in vitro in liver taken from Xenopus laevis tadpoles that are in late metamorphosis. Estradiol 0-10 a1-a Xenopus laevis 19-31 729904-0 1978 Estradiol-induced accumulation of vitellogenin mRNA and secretion of vitellogenin in liver cultures of Xenopus. Estradiol 0-9 a1-a Xenopus laevis 34-46 729904-0 1978 Estradiol-induced accumulation of vitellogenin mRNA and secretion of vitellogenin in liver cultures of Xenopus. Estradiol 0-9 a1-a Xenopus laevis 69-81 729904-1 1978 Explants of male Xenopus liver maintained in a serum-free culture medium respond to stimulation by 2 X 10(-8) M 17beta-estradiol with an increasing rate of accumulation of vitellogenin mRNA, as revealed by hybridization of cDNA to the total cytoplasmic RNA extracted from the cultures. Estradiol 112-128 a1-a Xenopus laevis 172-184 729904-4 1978 Since essential features of the in vivo response are maintained in liver explants, organ culture appears suitable for investigating initial events of estradiol action leading to enhanced synthesis of vitellogenin. Estradiol 150-159 a1-a Xenopus laevis 200-212 949740-0 1976 Direct induction by estradiol on vitellogenin synthesis in organ cultures of male Xenopus laevis liver. Estradiol 20-29 a1-a Xenopus laevis 33-45 708388-2 1978 Oestradiol-17beta induces livers of Xenopus laevis (South African clawed toad) to synthesize and secrete into the serum large quantities of the egg-yolk-protein precursor, vitellogenin. Estradiol 0-17 a1-a Xenopus laevis 172-184 1248478-5 1976 Vitellogenin synthesis was induced in male Xenopus liver by oestradiol treatment. Estradiol 60-70 a1-a Xenopus laevis 0-12 1248478-10 1976 RNA extracted from livers of oestradiol-treated male Xenopus and from purified polysomes is shown to code for the synthesis of vitellogenin-specific immunoprecipitable polypeptides in a rabbit reticulocyte cell-free protein-synthesizing system, a major component having a molecular weight of 210000. Estradiol 29-39 a1-a Xenopus laevis 127-139 719747-2 1978 It has a high affinity for estradiol (Kd = 0.5 x 10(-9) M), and the affinities of various steroids for the receptor correlate well with their ability to induce vitellogenin synthesis. Estradiol 27-36 a1-a Xenopus laevis 160-172 659432-2 1978 Administration of a secondary injection of estradiol-17 beta to male Xenopus laevis which have been withdrawn from estrogen for 60 days results in synthesis of complete vitellogenin mRNA molecules in as little as 1 h after restimulation. Estradiol 43-52 a1-a Xenopus laevis 169-181 949740-1 1976 Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin. Estradiol 63-80 a1-a Xenopus laevis 160-172 1059103-0 1975 Synthesis of vitellogenin in cultures of male and female frog liver regulated by estradiol treatment in vitro. Estradiol 81-90 a1-a Xenopus laevis 13-25 1270438-0 1976 In vitro translation and estradiol-17beta induction of Xenopus laevis vitellogenin messenger RNA. Estradiol 25-41 a1-a Xenopus laevis 70-82 1270438-1 1976 Administration of estradiol-17beta to male Xenopus laevis induces synthesis and secretion by the liver of the egg yolk precursor protein vitellogenin. Estradiol 18-34 a1-a Xenopus laevis 137-149 1270438-2 1976 RNA extracted from livers of estradiol-17beta-treated Xenopus laevis directs the synthesis of the entire 200,000-dalton vitellogenin monomer in a cell-free protein synthesizing system derived from rabbit reticulocytes. Estradiol 29-38 a1-a Xenopus laevis 120-132 1270438-9 1976 Vitellogenin synthesis is maximal 12 days after estradiol-17beta administration when it comprises approximately 70% of cell protein synthesis. Estradiol 48-64 a1-a Xenopus laevis 0-12 1270438-10 1976 The level of vitellogenin mRNA and the intracellular rate of vitellogenin synthesis exhibit a close correspondence from 4 to 16 days after administration of estradiol-17beta. Estradiol 157-173 a1-a Xenopus laevis 13-25 1270438-10 1976 The level of vitellogenin mRNA and the intracellular rate of vitellogenin synthesis exhibit a close correspondence from 4 to 16 days after administration of estradiol-17beta. Estradiol 157-173 a1-a Xenopus laevis 61-73 1059103-1 1975 Using the frog Xenopus laevis, we show that the addition of physiological concentrations of estradiol to cultures of liver from untreated males rapidly induces the synthesis of large amounts of vitellogenin. Estradiol 92-101 a1-a Xenopus laevis 194-206 1059103-2 1975 Sustained synthesis of vitellogenin requires continuous exposure to estradiol. Estradiol 68-77 a1-a Xenopus laevis 23-35 16141552-6 2005 Male frogs injected with 20 microg/g body weight of estradiol-17beta had significantly higher plasma Vg levels than the control group. Estradiol 52-68 a1-a Xenopus laevis 101-103 1117004-1 1975 Administration of a single injection of estradiol-17 beta to adult male Xenopus laevis induces the synthesis and secretion by the liver of the egg-yolk protein complex vitellogenin. Estradiol 40-57 a1-a Xenopus laevis 168-180 12520397-12 2003 Results also confirm the ability of 17beta-estradiol to stimulate production and release of VTG in the liver of male X. laevis, although we could not confirm the in vivo induction of VTG by estrogenic mimics octylphenol and nonylphenol. Estradiol 36-52 a1-a Xenopus laevis 92-95