PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30780843-1	2012	Carglumic acid is a structural analog and the first registered synthetic form of the naturally occurring allosteric activator of the urea cycle, N-acetylglutamate (NAG), which is the product of the enzyme NAG synthase (NAGS).	N-acetylglutamic acid	145-162	N-acetyl-alpha-glucosaminidase	Homo sapiens	164-167	
30337552-1	2018	N-acetylglutamate synthase deficiency (NAGSD, MIM #237310) is an autosomal recessive disorder of the urea cycle that results from absent or decreased production of N-acetylglutamate (NAG) due to either decreased NAGS gene expression or defective NAGS enzyme.	N-acetylglutamic acid	0-17	N-acetyl-alpha-glucosaminidase	Homo sapiens	39-42	
22383952-4	2012	N-acetylglutamate synthase (NAGS) produces a unique cofactor, N-acetylglutamate (NAG), that is essential for the catalytic function of the first and rate-limiting enzyme of ureagenesis, carbamyl phosphate synthetase 1 (CPS1).	N-acetylglutamic acid	0-17	N-acetyl-alpha-glucosaminidase	Homo sapiens	28-31	
23776373-2	2011	The initial and rate-limiting enzyme of the urea cycle, carbamylphosphate synthetase 1 (CPS1), requires an allosteric activator, N-acetylglutamate (NAG).	N-acetylglutamic acid	129-146	N-acetyl-alpha-glucosaminidase	Homo sapiens	148-151	
20303810-1	2010	N-acetylglutamate (NAG) is a unique enzyme cofactor, essential for liver ureagenesis in mammals while it is the first committed substrate for de novo arginine biosynthesis in microorganisms and plants.	N-acetylglutamic acid	0-17	N-acetyl-alpha-glucosaminidase	Homo sapiens	19-22	
16321554-1	2006	N-Acetylglutamate synthase (NAGS, EC 2.3.1.1) is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetylcoenzyme A.	N-acetylglutamic acid	104-121	N-acetyl-alpha-glucosaminidase	Homo sapiens	28-31	
15714518-1	2005	N-acetylglutamate (NAG) is a unique cofactor that is essential for the conversion of ammonia to urea in the liver.	N-acetylglutamic acid	0-17	N-acetyl-alpha-glucosaminidase	Homo sapiens	19-22	
15050968-2	2004	2.3.1.1) is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG), an essential allosteric activator of carbamylphosphate synthetase I (CPSI).	N-acetylglutamic acid	67-84	N-acetyl-alpha-glucosaminidase	Homo sapiens	86-89	
12459178-2	2002	2.3.1.1) is a mitochondrial enzyme catalyzing the formation of N-acetylglutamate (NAG), an essential allosteric activator of carbamylphosphate synthase I (CPSI), the first enzyme of the urea cycle.	N-acetylglutamic acid	63-80	N-acetyl-alpha-glucosaminidase	Homo sapiens	82-85	
3886433-4	1985	At physiological levels of ammonia the activation of carbamoyl-phosphate synthetase (EC 6.3.4.16) by N-acetylglutamate (NAG) is important.	N-acetylglutamic acid	101-118	N-acetyl-alpha-glucosaminidase	Homo sapiens	120-123	
29055942-2	2017	Oral administration of N-carbamoylglutamate (NCG), a synthetic analog of N-acetylglutamate (NAG), successfully decreases plasma ammonia levels in the affected children.	N-acetylglutamic acid	73-90	N-acetyl-alpha-glucosaminidase	Homo sapiens	92-95	
27771289-1	2016	BACKGROUND: N-acetylglutamate synthase (NAGS) plays a key role in the removal of ammonia via the urea cycle by catalyzing the synthesis of N-acetylglutamate (NAG), the obligatory cofactor in the carbamyl phosphate synthetase 1 reaction.	N-acetylglutamic acid	12-29	N-acetyl-alpha-glucosaminidase	Homo sapiens	40-43	
27570737-2	2016	Carbamoylphosphate synthetase 1 (CPS1), the first and rate-limiting enzyme of urea cycle, is activated by N-acetylglutamate (NAG), and thus N-acetylglutamate synthase (NAGS) is an essential part of the urea cycle.	N-acetylglutamic acid	106-123	N-acetyl-alpha-glucosaminidase	Homo sapiens	125-128	
26068232-1	2015	N-acetylglutamate synthase (NAGS) catalyzes the production of N-acetylglutamate (NAG) from acetyl-CoA and L-glutamate.	N-acetylglutamic acid	0-17	N-acetyl-alpha-glucosaminidase	Homo sapiens	28-31	
27934952-1	2016	N-acetylglutamate synthase (NAGS; E.C.2.3.1.1) catalyzes the formation of N-acetylglutamate (NAG) from acetyl coenzyme A and glutamate.	N-acetylglutamic acid	0-17	N-acetyl-alpha-glucosaminidase	Homo sapiens	28-31