PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31455676-11 2019 Expression of CYP3A4 and metabolism of triazolam, a typical CYP3A substrate, in the liver of CYP3A/PXR-humanized mice were enhanced in response to rifampicin, a typical human PXR activator. Triazolam 39-48 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 14-19 34013847-3 2021 The plasma concentrations ratios of alpha-hydroxytriazolam and 4-hydroxytriazolam to triazolam in portal blood were significantly decreased by multiple administration of clarithromycin in CYP3A-humanised mice.These results suggest that intestinal CYP3A activity was inhibited by macrolide antibiotics in CYP3A-humanised mice in vitro and in vivo. Triazolam 49-58 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 188-193 34013847-4 2021 The plasma concentrations of triazolam and its metabolites in the portal blood of CYP3A-humanised mice would be useful for direct evaluation of intestinal CYP3A-mediated drug-drug interactions. Triazolam 29-38 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 82-87 34013847-4 2021 The plasma concentrations of triazolam and its metabolites in the portal blood of CYP3A-humanised mice would be useful for direct evaluation of intestinal CYP3A-mediated drug-drug interactions. Triazolam 29-38 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 155-160 31455676-11 2019 Expression of CYP3A4 and metabolism of triazolam, a typical CYP3A substrate, in the liver of CYP3A/PXR-humanized mice were enhanced in response to rifampicin, a typical human PXR activator. Triazolam 39-48 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 60-65 31455676-12 2019 Enhancement of triazolam metabolism in the intestine of CYP3A/PXR-humanized mice was firstly shown by combination of mass spectrometry imaging of sliced intestine and liquid chromatography with tandem mass spectrometry analysis of metabolite concentration in portal blood after oral dosing of triazolam. Triazolam 15-24 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 56-61 31455676-12 2019 Enhancement of triazolam metabolism in the intestine of CYP3A/PXR-humanized mice was firstly shown by combination of mass spectrometry imaging of sliced intestine and liquid chromatography with tandem mass spectrometry analysis of metabolite concentration in portal blood after oral dosing of triazolam. Triazolam 293-302 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 56-61 10230766-2 1999 The in vitro kinetic parameters of CYP3A-mediated metabolism of midazolam (MDZ), triazolam (TRZ), and dexamethasone (DEX) were studied in liver microsomes from three mrdrla(-/-) mice, one mdrla/b(-/-) mouse, and mdrla/b(+/+) controls. Triazolam 81-90 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 35-40 30561249-2 2019 To investigate cytochrome P450 3A (CYP3A)-mediated metabolism in vivo, plasma concentrations of triazolam (TRZ) are often monitored as a CYP3A marker in CYP3A-humanised mice. Triazolam 96-105 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 35-40 25757928-2 2015 This study evaluated the effects of menthol on the pharmacokinetics of the CYP3A substrate triazolam and the CYP2C substrate phenytoin. Triazolam 91-100 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 75-80 25757928-4 2015 In addition, the CYP3A metabolic activity for triazolam and the CYP3A expression level in the liver were determined. Triazolam 46-55 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 17-22 23282066-0 2013 Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam. Triazolam 171-180 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 105-110 22659374-4 2012 Triazolam, which is a substrate of Cyp3a, was intraperitoneally administered to the mice in the HF group. Triazolam 0-9 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 35-40 28393714-6 2017 CYP3A activity was determined as alpha- and 4-hydroxylation activity of triazolam in liver and intestinal microsomes. Triazolam 72-81 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 0-5 28393714-9 2017 RESULTS: The results showed that triazolam hydroxylation activities and protein levels of CYP3A in the liver were significantly higher in female than in male CYP3A-HAC mice, whereas those in the intestine were not significantly different between the genders. Triazolam 33-42 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 158-163 19752211-3 2009 Triazolam was used as a probe drug because it is a highly specific CYP3A substrate and not a P-glycoprotein substrate. Triazolam 0-9 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 67-72 19752211-4 2009 Triazolam metabolism was profoundly reduced in Cyp3a(-/-) mice both in vitro and in vivo. Triazolam 0-9 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 47-52 19752211-7 2009 To mimic a drug-drug interaction, we coadministered triazolam with the prototypical CYP3A inhibitor ketoconazole, which increased triazolam exposure in all the CYP3A-proficient mouse strains but not in Cyp3a(-/-) mice. Triazolam 52-61 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 160-165 19752211-7 2009 To mimic a drug-drug interaction, we coadministered triazolam with the prototypical CYP3A inhibitor ketoconazole, which increased triazolam exposure in all the CYP3A-proficient mouse strains but not in Cyp3a(-/-) mice. Triazolam 130-139 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 84-89 10230766-0 1999 Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes. Triazolam 77-86 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 10-28 10230766-0 1999 Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes. Triazolam 77-86 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 30-35 10230766-2 1999 The in vitro kinetic parameters of CYP3A-mediated metabolism of midazolam (MDZ), triazolam (TRZ), and dexamethasone (DEX) were studied in liver microsomes from three mrdrla(-/-) mice, one mdrla/b(-/-) mouse, and mdrla/b(+/+) controls. Triazolam 92-95 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 35-40