PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12069074-3	2002	When a human myelomonocytic cell line U937 was treated with phorbol 12-myristate 13-acetate for 3 days, the LPS-induced MAIL expression was much potentiated in parallel with an increase in TLR4 expression.	Tetradecanoylphorbol Acetate	60-91	toll like receptor 4	Homo sapiens	189-193	
33841142-7	2021	The secretion and the mRNA expression of cytokines related to TLR4 signaling significantly increased after SYQP treatment in both PMA-induced THP-1 and RAW264.7 macrophage cell lines.	Tetradecanoylphorbol Acetate	130-133	toll like receptor 4	Homo sapiens	62-66	
33801658-7	2021	RESULTS: The two sphingosine-1-phosphate receptors (S1PRs) expressed in peritoneal B cell subsets S1P1 and S1P4 are differentially regulated upon stimulation with the TLR4 agonist LPS, but not upon PMA/ionomycin or B cell receptor (BCR) crosslinking.	Tetradecanoylphorbol Acetate	198-201	toll like receptor 4	Homo sapiens	167-171	
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	113-116	toll like receptor 4	Homo sapiens	70-74	
29207123-7	2018	In conclusion, berberine reduced NLRP3 inflammasone expression by suppressing the activation of the TLR4/Myd88/NF-kappaB signaling pathway in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	142-145	toll like receptor 4	Homo sapiens	100-104	
28765923-0	2017	Bombyx mori hemocyte extract has anti-inflammatory effects on human phorbol myristate acetate-differentiated THP-1 cells via TLR4-mediated suppression of the NF-kappaB signaling pathway.	Tetradecanoylphorbol Acetate	68-93	toll like receptor 4	Homo sapiens	125-129	
29207123-0	2018	NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-kappaB pathway, in phorbol 12-myristate 13-acetate-induced macrophages.	Tetradecanoylphorbol Acetate	209-240	toll like receptor 4	Homo sapiens	105-125	
24732112-5	2014	Furthermore, the effect of the extracts, EUG and IMT, was studied on phorbol-12-myristate-13-acetate (PMA) induced monocyte to macrophage differentiation and gene expression of CD14, TLR2 and TLR4.	Tetradecanoylphorbol Acetate	69-100	toll like receptor 4	Homo sapiens	192-196	
24732112-5	2014	Furthermore, the effect of the extracts, EUG and IMT, was studied on phorbol-12-myristate-13-acetate (PMA) induced monocyte to macrophage differentiation and gene expression of CD14, TLR2 and TLR4.	Tetradecanoylphorbol Acetate	102-105	toll like receptor 4	Homo sapiens	192-196	
24732112-10	2014	In addition, they showed significant inhibition on PMA induced monocyte to macrophage differentiation and the gene expression of CD14, TLR2 and TLR4 markers.	Tetradecanoylphorbol Acetate	51-54	toll like receptor 4	Homo sapiens	144-148	
21804018-4	2011	Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs.	Tetradecanoylphorbol Acetate	10-13	toll like receptor 4	Homo sapiens	93-97	
22685674-3	2012	We have found that TPA-induced differentiation of ML-1 cells was accompanied by the upregulation of TLR1, TLR2, TLR4, and CD14 expression at both the mRNA and protein levels.	Tetradecanoylphorbol Acetate	19-22	toll like receptor 4	Homo sapiens	112-116	
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	36-73	toll like receptor 4	Homo sapiens	28-32	
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	75-78	toll like receptor 4	Homo sapiens	28-32	
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	75-78	toll like receptor 4	Homo sapiens	174-178	
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	149-152	toll like receptor 4	Homo sapiens	28-32	
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	149-152	toll like receptor 4	Homo sapiens	174-178