PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20883105-3 2010 To understand the role that p44/42 activation plays in TBT-induced loss of NK cell function, this study investigated how selective activation of p44/42 by phorbol 12-myristate 13-acetate (PMA) affects NK cells. Tetradecanoylphorbol Acetate 155-186 interferon induced protein 44 Homo sapiens 145-148 21939515-6 2011 Western blot analysis revealed differences in the expression levels and altered phosphorylation patterns of Pyk-2, pp60src and p42/p44 MAP kinases between pMTH1-U937 and asCD11b-U937 following TPA exposure which was also substantiated by Pyk-2 immunoprecipitation. Tetradecanoylphorbol Acetate 193-196 interferon induced protein 44 Homo sapiens 131-134 20883105-3 2010 To understand the role that p44/42 activation plays in TBT-induced loss of NK cell function, this study investigated how selective activation of p44/42 by phorbol 12-myristate 13-acetate (PMA) affects NK cells. Tetradecanoylphorbol Acetate 188-191 interferon induced protein 44 Homo sapiens 145-148 15666830-7 2004 Taken together these results suggest that TPA inhibits the AII-dependent activation of CYP11B2 via the p44/42 MAPK signaling pathway leading to an increase of the level of nuclear JunB. Tetradecanoylphorbol Acetate 42-45 interferon induced protein 44 Homo sapiens 103-106 20213532-3 2010 If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures. Tetradecanoylphorbol Acetate 160-191 interferon induced protein 44 Homo sapiens 17-20 20213532-3 2010 If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures. Tetradecanoylphorbol Acetate 160-191 interferon induced protein 44 Homo sapiens 100-103 20213532-3 2010 If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures. Tetradecanoylphorbol Acetate 193-196 interferon induced protein 44 Homo sapiens 100-103 20213532-6 2010 Western blot analysis showed that a 1-h exposure to 5 nM PMA caused a sixfold increase in phospho-p44/42 levels. Tetradecanoylphorbol Acetate 57-60 interferon induced protein 44 Homo sapiens 98-101 17207890-12 2007 Immunoblotting experiments showed that TPA was more potent than TNF-alpha to induce in a PKCalpha/beta dependent manner the p44/p42 mitogen-activated protein kinases (MAPK) signaling cascade which controls AP-1 activity. Tetradecanoylphorbol Acetate 39-42 interferon induced protein 44 Homo sapiens 124-127 15666830-2 2004 Here we report that TPA increased the level of phospho-p44/42 MAPK but AII did not. Tetradecanoylphorbol Acetate 20-23 interferon induced protein 44 Homo sapiens 55-58 15147830-2 2004 Treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) or interferon-gamma (IFN-gamma) (100 U/ml) induced phosphorylation of p44/42 MAPK. Tetradecanoylphorbol Acetate 52-88 interferon induced protein 44 Homo sapiens 175-178 12137745-7 2002 PMA also induced phosphorylation of p44/p42 extracellular signal-regulated kinases (ERK) 1 and 2. Tetradecanoylphorbol Acetate 0-3 interferon induced protein 44 Homo sapiens 36-39 10775036-5 2000 PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1. Tetradecanoylphorbol Acetate 0-3 interferon induced protein 44 Homo sapiens 79-82 12039887-13 2002 PMA phosphorylated both p38 and p44/42 MAPK. Tetradecanoylphorbol Acetate 0-3 interferon induced protein 44 Homo sapiens 32-35 11920638-3 2002 We show that a prolonged OHT treatment (for up to 7 days) led to a progressive increase in the level of phosphorylated p44/42 mitogen activated kinase (MAP kinase) induced by 10(-7) M TPA stimulation, without any significant change in the protein level. Tetradecanoylphorbol Acetate 184-187 interferon induced protein 44 Homo sapiens 119-122 10775036-5 2000 PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1. Tetradecanoylphorbol Acetate 175-178 interferon induced protein 44 Homo sapiens 79-82 8530489-5 1995 The presence of EGFRvIII suppresses activation of p42 and p44 MAP kinases by phorbol 12-myristate 13-acetate (PMA) and serum; however, MEK activation by PMA is not suppressed by EGFRvIII. Tetradecanoylphorbol Acetate 77-108 interferon induced protein 44 Homo sapiens 58-61 10051531-5 1999 Marked or slight activation, respectively, of p44/42 MAPK or p38 was also seen after 10-min treatment with 12-O-tetradecanoylphorbol-13-acetate, but c-Jun NH2-terminal kinase activation did not occur. Tetradecanoylphorbol Acetate 107-143 interferon induced protein 44 Homo sapiens 46-49 9885438-5 1998 On the other hand, TNF selectively induced tyrosine phosphorylation of p42, and PMA selectively induced that of p44 and p42. Tetradecanoylphorbol Acetate 80-83 interferon induced protein 44 Homo sapiens 112-115 9368070-7 1997 The PMA-induced phosphorylation was selectively suppressed by an inhibitor of p44 MAP kinase kinase, PD98059. Tetradecanoylphorbol Acetate 4-7 interferon induced protein 44 Homo sapiens 78-81 9067628-7 1997 We report here that erythropoietin, inositolphosphate-glycan, and 12-O-tetradecanoyl-phorbol-13-acetate activated only the p44 form (erk-1) of MAP kinase and the Raf-1 protein. Tetradecanoylphorbol Acetate 66-103 interferon induced protein 44 Homo sapiens 123-126 8530489-5 1995 The presence of EGFRvIII suppresses activation of p42 and p44 MAP kinases by phorbol 12-myristate 13-acetate (PMA) and serum; however, MEK activation by PMA is not suppressed by EGFRvIII. Tetradecanoylphorbol Acetate 110-113 interferon induced protein 44 Homo sapiens 58-61 6436129-2 1984 Both TPA and teleocidin B caused a marked increase in the synthesis of two polypeptides with molecular weights of 44 kilodaltons (p44) and 55 kilodaltons (p55). Tetradecanoylphorbol Acetate 5-8 interferon induced protein 44 Homo sapiens 130-133