PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16493010-2	2006	Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antiphospholipid antibodies.	Tetradecanoylphorbol Acetate	116-119	annexin A2	Homo sapiens	0-9	
19377918-4	2009	Though both tPA and uPA are expressed in tumor cells, uPA with its receptor (uPAR) is mostly involved in cellular functions, while tPA with its receptor Annexin II on endothelial surface, regulates intravascular fibrin deposition.	Tetradecanoylphorbol Acetate	131-134	annexin A2	Homo sapiens	153-163	
18220793-4	2007	Annexin II is one of the well studied receptors for plasminogen and tPA, which binds to plasminogen and converts it to plasmin.	Tetradecanoylphorbol Acetate	68-71	annexin A2	Homo sapiens	0-10	
16493010-2	2006	Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antiphospholipid antibodies.	Tetradecanoylphorbol Acetate	116-119	annexin A2	Homo sapiens	11-13	
16493010-6	2006	Anti-A2 IgG enhanced the expression of tissue factor on endothelial cells (6.4-fold +/- 0.13-fold SE), blocked A2-supported plasmin generation in a tPA-dependent generation assay (19%-71%) independently of beta2GPI, and inhibited cell surface plasmin generation on human umbilical vein endothelial cells (HUVECs) by 34% to 83%.	Tetradecanoylphorbol Acetate	148-151	annexin A2	Homo sapiens	5-7	
16493010-6	2006	Anti-A2 IgG enhanced the expression of tissue factor on endothelial cells (6.4-fold +/- 0.13-fold SE), blocked A2-supported plasmin generation in a tPA-dependent generation assay (19%-71%) independently of beta2GPI, and inhibited cell surface plasmin generation on human umbilical vein endothelial cells (HUVECs) by 34% to 83%.	Tetradecanoylphorbol Acetate	148-151	annexin A2	Homo sapiens	111-113	
12468550-0	2003	New insights into the tPA-annexin A2 interaction.	Tetradecanoylphorbol Acetate	22-25	annexin A2	Homo sapiens	26-36	
12627665-10	2003	Another example was seen recently in the antiphospholipid syndrome, where antibodies against Annexin II, a receptor for tPA, were found to be higher than in healthy controls.	Tetradecanoylphorbol Acetate	120-123	annexin A2	Homo sapiens	93-103	
12468550-4	2003	The annexin A2 motif that mediates tissue plasminogen activator interaction has been assigned to the hexapeptide LCKLSL in the amino-terminal domain of the protein, and it has been proposed that Cys(8) of this sequence is essential for tPA binding.	Tetradecanoylphorbol Acetate	236-239	annexin A2	Homo sapiens	4-14	
12468550-5	2003	In an attempt to identify other amino acids critical for tPA-annexin A2 interaction, we have analyzed a set of peptides containing several modifications of the original hexapeptide, including glycine scans, alanine scans, d-amino acid scans, conservative mutations, cysteine blocking, and enantiomer and retroenantiomer sequences.	Tetradecanoylphorbol Acetate	57-60	annexin A2	Homo sapiens	61-71	
12468550-6	2003	Using a non-radioactive competitive binding assay, we have found that all cysteine-containing peptides, independently of their sequence, compete the interaction between tPA and annexin A2.	Tetradecanoylphorbol Acetate	169-172	annexin A2	Homo sapiens	177-187	
12468550-9	2003	These data call for a revision of the role of the LCKLSL sequence as the sole annexin A2 structural region required to bind tPA and indicate that further studies are necessary to better define the annexin A2-tPA interaction.	Tetradecanoylphorbol Acetate	208-211	annexin A2	Homo sapiens	197-207	
7980409-6	1994	After stimulation with phorbol 12-myristate 13-acetate and phytohaemagglutinin for 10 min, p105-NF-kappa B and p50-NF-kappa B, but not p36-I kappa B, were highly phosphorylated.	Tetradecanoylphorbol Acetate	23-54	annexin A2	Homo sapiens	135-138	
23702712-11	2013	ANX A2 depletion significantly inhibited TNF-alpha shedding by interleukin-1beta and TPA.	Tetradecanoylphorbol Acetate	85-88	annexin A2	Homo sapiens	0-6	
23702712-14	2013	CONCLUSIONS: ANX A2 was closely associated with ADAM17 and played an important role in TNF-alpha shedding by TPA.	Tetradecanoylphorbol Acetate	109-112	annexin A2	Homo sapiens	13-19	
33140258-5	2021	Potential pathologic factors that are related to the suboptimal tPA recanalization in diabetic stroke include higher plasma plasminogen activator inhibitor (PAI)-1 level, diabetic atherogenic vascular damage, glycation of the tPA receptor annexin A2, and alterations in fibrin clot density.	Tetradecanoylphorbol Acetate	64-67	annexin A2	Homo sapiens	239-249