PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2957212-8 1987 In Ichikawa cells, however, PMA induced surface expression of a mature T3/TCR complex. Tetradecanoylphorbol Acetate 28-31 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 74-77 2478302-6 1989 The requirement for TcR crosslinking in triggering both secretion of granules and secretion of IFN from CTL was pharmacologically reproduced by the synergistic action of PMA, a protein kinase C activator, and the Ca2+ ionophore A23187. Tetradecanoylphorbol Acetate 170-173 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 20-23 3261760-3 1988 Subsequent to PMA-induced modulation of the TCR/CD3 complex, increases in the mRNA levels of both the TCR-alpha and -beta genes were observed reaching a maximum 12 h after stimulation. Tetradecanoylphorbol Acetate 14-17 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 44-47 3261760-3 1988 Subsequent to PMA-induced modulation of the TCR/CD3 complex, increases in the mRNA levels of both the TCR-alpha and -beta genes were observed reaching a maximum 12 h after stimulation. Tetradecanoylphorbol Acetate 14-17 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 102-105 2838469-4 1988 The induction of TcR-alpha and -delta mRNA by 12-O-tetradecanoylphorbol-13-acetate occurred at the transcriptional level only whereas cAMP treatment decreased both TcR-alpha gene transcription and the stability of its mRNA. Tetradecanoylphorbol Acetate 46-82 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 17-20 3257235-2 1988 Activation of protein kinase C by the phorbol ester, tetradecanoyl phorbol acetate or other phorbol esters increases the levels of the alpha and beta T cell receptor (TcR-alpha, TcR-beta) mRNA, whereas an increase in cytosolic free Ca2+, induced by ionomycin or other Ca2+ ionophores, results in a decrease of alpha and beta TcR mRNA levels. Tetradecanoylphorbol Acetate 53-82 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 178-186 3257235-2 1988 Activation of protein kinase C by the phorbol ester, tetradecanoyl phorbol acetate or other phorbol esters increases the levels of the alpha and beta T cell receptor (TcR-alpha, TcR-beta) mRNA, whereas an increase in cytosolic free Ca2+, induced by ionomycin or other Ca2+ ionophores, results in a decrease of alpha and beta TcR mRNA levels. Tetradecanoylphorbol Acetate 53-82 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 167-170 16172133-4 2005 Ex vivo stimulation of DP thymocytes with phorbol myristate acetate or antibodies that activate the TCR complex led to the accumulation of DRAK2 in a protein kinase C- and MAP Kinase-dependent fashion. Tetradecanoylphorbol Acetate 42-67 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 100-103 20936133-4 2010 This correlation was abolished when the cells were stimulated with TPA and ionomycin, which bypass TCR and introduce signals directly into the cells, but the production of IFN-gamma by SLE T cells remained abnormally elevated. Tetradecanoylphorbol Acetate 67-70 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 99-102 12766168-3 2003 Here, we show that non-transformed T cell lines obtained from XLP patients were defective in several activation events such as IL-2 production, CD25 expression, and homotypic cell aggregation when cells were stimulated via T cell antigen receptor (TCR).CD3 but not when early TCR-dependent events were bypassed by stimulation with phorbol 12-myristate 13-acetate/ionomycin. Tetradecanoylphorbol Acetate 331-362 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 223-246 12766168-3 2003 Here, we show that non-transformed T cell lines obtained from XLP patients were defective in several activation events such as IL-2 production, CD25 expression, and homotypic cell aggregation when cells were stimulated via T cell antigen receptor (TCR).CD3 but not when early TCR-dependent events were bypassed by stimulation with phorbol 12-myristate 13-acetate/ionomycin. Tetradecanoylphorbol Acetate 331-362 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 248-251 12595531-9 2003 Furthermore, T cells treated with soluble anti-TCR antibody produced IL-2 when phorbol 12-myristate 13-acetate, which activates ERK, was present in the culture medium 2-6 h after the start of stimulation. Tetradecanoylphorbol Acetate 79-110 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 47-50 1730605-3 1992 Nuclear extracts from cells stimulated with phorbol 12-myristate 13-acetate and ionomycin, which activate protein kinase C and mimic physiological activation through the T-cell antigen receptor, transcribe an interleukin-2 (IL-2) enhancer (-326 to +24) template 5-fold more efficient than nuclear extracts from resting T-cells and severalfold more efficient than extracts from Jurkat cells treated with phorbol 12-myristate 13-acetate or ionomycin alone. Tetradecanoylphorbol Acetate 44-75 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 170-193 12482394-3 2002 The cytochrome c-sensitive TCR-expressing hybridoma (2B4) was stimulated with pigeon cytochrome c antigen, anti-CD3 crosslinking, or PMA and ionomycin, in the presence or absence of CP, and the resulting IL-2 produced was measured in a bioassay using an IL-2-dependent cell line (CTLL-2). Tetradecanoylphorbol Acetate 133-136 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 27-30 9576485-5 1998 These effects were blocked by phorbol 12-myristate 13-acetate (PMA) and were dependent on the presence of a functional TCR/CD3 surface complex, no effects being recorded on mutant Jurkat cells lacking part of the CD3 structures. Tetradecanoylphorbol Acetate 30-61 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 119-122 9576485-5 1998 These effects were blocked by phorbol 12-myristate 13-acetate (PMA) and were dependent on the presence of a functional TCR/CD3 surface complex, no effects being recorded on mutant Jurkat cells lacking part of the CD3 structures. Tetradecanoylphorbol Acetate 63-66 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 119-122 9247590-3 1997 We report that the mutation of S126 in the CD3-gamma chain that is known to inhibit phorbol-12-myristate 13-acetate-induced TCR down-regulation does not affect down-regulation induced by a specific agonist. Tetradecanoylphorbol Acetate 84-115 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 124-127 8948021-6 1996 Proper crosslinking of TCR together with CD4, CD8, or LFA-1 inhibits the death, and its inhibitory activity is mimicked by proper combinations of ionomycin, a calcium ionophore, and phorbol myristate acetate (PMA), a protein kinase C (PKC) activator. Tetradecanoylphorbol Acetate 182-207 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 23-26 1398515-3 1992 On activation with 12-O-tetradecanoylphorbol-13-acetate (TPA) these cells express the CD3 antigen and the T cell receptor alpha beta (TCR alpha beta) on the cell surface. Tetradecanoylphorbol Acetate 19-55 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 134-137 1398515-3 1992 On activation with 12-O-tetradecanoylphorbol-13-acetate (TPA) these cells express the CD3 antigen and the T cell receptor alpha beta (TCR alpha beta) on the cell surface. Tetradecanoylphorbol Acetate 57-60 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 134-137 1398515-6 1992 Different subclones of the Co cell line differed in their response to TPA with respect to the induced CD3 and TCR expression. Tetradecanoylphorbol Acetate 70-73 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 110-113 8500530-1 1993 The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain. Tetradecanoylphorbol Acetate 14-45 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 119-134 8500530-1 1993 The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain. Tetradecanoylphorbol Acetate 14-45 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 136-139 8500530-1 1993 The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain. Tetradecanoylphorbol Acetate 47-50 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 119-134 8500530-1 1993 The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain. Tetradecanoylphorbol Acetate 47-50 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 136-139 8500530-6 1993 However, for all cell lines studied the amount of TcR complexes expressed on the cell surface was decreased after 16 h of PMA treatment. Tetradecanoylphorbol Acetate 122-125 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 50-53 1730605-3 1992 Nuclear extracts from cells stimulated with phorbol 12-myristate 13-acetate and ionomycin, which activate protein kinase C and mimic physiological activation through the T-cell antigen receptor, transcribe an interleukin-2 (IL-2) enhancer (-326 to +24) template 5-fold more efficient than nuclear extracts from resting T-cells and severalfold more efficient than extracts from Jurkat cells treated with phorbol 12-myristate 13-acetate or ionomycin alone. Tetradecanoylphorbol Acetate 403-434 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 170-193